메뉴 건너뛰기




Volumn 20, Issue 6, 2013, Pages 549-556

Understanding pancreatic cancer genomes

Author keywords

Clinical trial; Functional genomics; Genome sequencing; Molecular heterogeneity; Molecular taxonomy; Pancreatic cancer

Indexed keywords

CISPLATIN; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; MITOMYCIN; OXALIPLATIN; PLATINUM DERIVATIVE; TRASTUZUMAB;

EID: 84881474788     PISSN: 18686974     EISSN: 18686982     Source Type: Journal    
DOI: 10.1007/s00534-013-0610-6     Document Type: Article
Times cited : (34)

References (23)
  • 1
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • 10.3322/caac.20138 10.3322/caac.20138
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA: A Cancer J Clin. 2012;62(1):10-29. doi: 10.3322/caac.20138.
    • (2012) CA: A Cancer J Clin , vol.62 , Issue.1 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 2
    • 38549092718 scopus 로고    scopus 로고
    • Influence of resection margins and treatment on survival in patients with pancreatic cancer: Meta-analysis of randomized controlled trials
    • 10.1001/archsurg.2007.17 18209156 10.1001/archsurg.2007.17 Discussion
    • Butturini G, Stocken DD, Wente MN, Jeekel H, Klinkenbijl JH, Bakkevold KE, et al. Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials. Arch Surg. 2008;143(1):75-83. doi: 10.1001/archsurg.2007.17 (Discussion).
    • (2008) Arch Surg , vol.143 , Issue.1 , pp. 75-83
    • Butturini, G.1    Stocken, D.D.2    Wente, M.N.3    Jeekel, H.4    Klinkenbijl, J.H.5    Bakkevold, K.E.6
  • 3
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: A randomized controlled trial
    • 10.1001/jama.2010.1275 20823433 10.1001/jama.2010.1275 1:CAS:528:DC%2BC3cXhtFequ7nE
    • Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 2010;304(10):1073-81. doi: 10.1001/jama.2010.1275.
    • (2010) JAMA , vol.304 , Issue.10 , pp. 1073-1081
    • Neoptolemos, J.P.1    Stocken, D.D.2    Bassi, C.3    Ghaneh, P.4    Cunningham, D.5    Goldstein, D.6
  • 4
    • 69949185673 scopus 로고    scopus 로고
    • Update on pancreatic intraepithelial neoplasia
    • 18787611 1:CAS:528:DC%2BD1cXpt1Gnur0%3D
    • Hruban RH, Maitra A, Goggins M. Update on pancreatic intraepithelial neoplasia. Int J Clin Exp Pathol. 2008;1(4):306-16.
    • (2008) Int J Clin Exp Pathol , vol.1 , Issue.4 , pp. 306-316
    • Hruban, R.H.1    Maitra, A.2    Goggins, M.3
  • 5
    • 84856955522 scopus 로고    scopus 로고
    • The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
    • 10.1038/nrgastro.2011.215 22183185
    • Samuel N, Hudson TJ. The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma. Nat Rev Gastroenterol Hepatol. 2011;. doi: 10.1038/nrgastro.2011.215.
    • (2011) Nat Rev Gastroenterol Hepatol
    • Samuel, N.1    Hudson, T.J.2
  • 6
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • 10.1038/nature08987 20393554 10.1038/nature08987 1:CAS:528: DC%2BC3cXkslart70%3D
    • Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabe RR, et al. International network of cancer genome projects. Nature. 2010;464(7291):993-8. doi: 10.1038/nature08987.
    • (2010) Nature , vol.464 , Issue.7291 , pp. 993-998
    • Hudson, T.J.1    Anderson, W.2    Artez, A.3    Barker, A.D.4    Bell, C.5    Bernabe, R.R.6
  • 7
    • 84866700697 scopus 로고    scopus 로고
    • Qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles
    • 10.1371/journal.pone.0045835 23049875 10.1371/journal.pone.0045835 1:CAS:528:DC%2BC38XhsVGhtbzP
    • Song S, Nones K, Miller D, Harliwong I, Kassahn KS, Pinese M, et al. qpure: a tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles. PLoS ONE. 2012;7(9):e45835. doi: 10.1371/journal.pone. 0045835.
    • (2012) PLoS ONE , vol.7 , Issue.9 , pp. 45835
    • Song, S.1    Nones, K.2    Miller, D.3    Harliwong, I.4    Kassahn, K.S.5    Pinese, M.6
  • 8
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • 10.1126/science.1164368 18772397 10.1126/science.1164368 1:CAS:528:DC%2BD1cXhtFCrtLrL
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321(5897):1801-6. doi: 10.1126/science.1164368.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 9
    • 84864598664 scopus 로고    scopus 로고
    • MuSiC: Identifying mutational significance in cancer genomes
    • 10.1101/gr.134635.111 22759861 10.1101/gr.134635.111 1:CAS:528: DC%2BC38XhtFOnsLrE
    • Dees ND, Zhang Q, Kandoth C, Wendl MC, Schierding W, Koboldt DC, et al. MuSiC: identifying mutational significance in cancer genomes. Genome Res. 2012;22(8):1589-98. doi: 10.1101/gr.134635.111.
    • (2012) Genome Res , vol.22 , Issue.8 , pp. 1589-1598
    • Dees, N.D.1    Zhang, Q.2    Kandoth, C.3    Wendl, M.C.4    Schierding, W.5    Koboldt, D.C.6
  • 10
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • 10.1038/nature11547 23103869 10.1038/nature11547 1:CAS:528: DC%2BC38XhsFOmt7jN
    • Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012;491(7424):399-405. doi: 10.1038/nature11547.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 399-405
    • Biankin, A.V.1    Waddell, N.2    Kassahn, K.S.3    Gingras, M.C.4    Muthuswamy, L.B.5    Johns, A.L.6
  • 11
    • 84863830403 scopus 로고    scopus 로고
    • ATM mutations in patients with hereditary pancreatic cancer
    • 10.1158/2159-8290.cd-11-0194 22585167 10.1158/2159-8290.CD-11-0194 1:CAS:528:DC%2BC38XmtlKgsQ%3D%3D
    • Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, et al. ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov. 2012;2(1):41-6. doi: 10.1158/2159-8290.cd-11-0194.
    • (2012) Cancer Discov , vol.2 , Issue.1 , pp. 41-46
    • Roberts, N.J.1    Jiao, Y.2    Yu, J.3    Kopelovich, L.4    Petersen, G.M.5    Bondy, M.L.6
  • 12
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • 10.1186/gb-2011-12-4-r41 21527027 10.1186/gb-2011-12-4-r41
    • Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R, Getz G. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 2011;12(4):R41. doi: 10.1186/gb-2011-12-4-r41.
    • (2011) Genome Biol , vol.12 , Issue.4 , pp. 41
    • Mermel, C.H.1    Schumacher, S.E.2    Hill, B.3    Meyerson, M.L.4    Beroukhim, R.5    Getz, G.6
  • 13
    • 84859947197 scopus 로고    scopus 로고
    • Sleeping beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • 10.1073/pnas.1202490109 22421440 10.1073/pnas.1202490109 1:CAS:528:DC%2BC38Xmt12mtr0%3D
    • Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, et al. Sleeping beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci USA. 2012;109(16):5934-41. doi: 10.1073/pnas.1202490109.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.16 , pp. 5934-5941
    • Mann, K.M.1    Ward, J.M.2    Yew, C.C.3    Kovochich, A.4    Dawson, D.W.5    Black, M.A.6
  • 14
    • 84861990162 scopus 로고    scopus 로고
    • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
    • 10.1038/nature11114 22699621 1:CAS:528:DC%2BC38Xos1emsbc%3D
    • Perez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature. 2012;486(7402):266-70. doi: 10.1038/nature11114.
    • (2012) Nature , vol.486 , Issue.7402 , pp. 266-270
    • Perez-Mancera, P.A.1    Rust, A.G.2    Van Der Weyden, L.3    Kristiansen, G.4    Li, A.5    Sarver, A.L.6
  • 15
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
    • 10.1073/pnas.1109363108 21746896 10.1073/pnas.1109363108 1:CAS:528:DC%2BC3MXpvV2lsrk%3D
    • Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci USA. 2011;108(30):12372-7. doi: 10.1073/pnas.1109363108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.30 , pp. 12372-12377
    • Cheung, H.W.1    Cowley, G.S.2    Weir, B.A.3    Boehm, J.S.4    Rusin, S.5    Scott, J.A.6
  • 16
    • 70449418416 scopus 로고    scopus 로고
    • Integrated study of copy number states and genotype calls using high-density SNP arrays
    • 10.1093/nar/gkp493 19581427 10.1093/nar/gkp493 1:CAS:528: DC%2BD1MXht1Oqs7%2FO
    • Sun W, Wright FA, Tang Z, Nordgard SH, Van Loo P, Yu T, et al. Integrated study of copy number states and genotype calls using high-density SNP arrays. Nucleic Acids Res. 2009;37(16):5365-77. doi: 10.1093/nar/gkp493.
    • (2009) Nucleic Acids Res , vol.37 , Issue.16 , pp. 5365-5377
    • Sun, W.1    Wright, F.A.2    Tang, Z.3    Nordgard, S.H.4    Van Loo, P.5    Yu, T.6
  • 17
    • 79952027445 scopus 로고    scopus 로고
    • Novel roles for slits and netrins: Axon guidance cues as anticancer targets?
    • 10.1038/nrc3005 21326323 10.1038/nrc3005 1:CAS:528:DC%2BC3MXitVClurc%3D
    • Mehlen P, Delloye-Bourgeois C, Chedotal A. Novel roles for slits and netrins: axon guidance cues as anticancer targets? Nat Rev Cancer. 2011;11(3):188-97. doi: 10.1038/nrc3005.
    • (2011) Nat Rev Cancer , vol.11 , Issue.3 , pp. 188-197
    • Mehlen, P.1    Delloye-Bourgeois, C.2    Chedotal, A.3
  • 18
    • 79959929490 scopus 로고    scopus 로고
    • Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes
    • 10.1007/s00439-011-0990-0 21516344 10.1007/s00439-011-0990-0 1:CAS:528:DC%2BC3MXotlyrtbo%3D
    • Pajic M, Scarlett CJ, Chang DK, Sutherland RL, Biankin AV. Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes. Hum Genet. 2011;130(1):93-101. doi: 10.1007/s00439-011-0990-0.
    • (2011) Hum Genet , vol.130 , Issue.1 , pp. 93-101
    • Pajic, M.1    Scarlett, C.J.2    Chang, D.K.3    Sutherland, R.L.4    Biankin, A.V.5
  • 19
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • 10.1016/s0140-6736(10)61121-x 20728210 10.1016/S0140-6736(10)61121-X 1:CAS:528:DC%2BC3cXhtVymt7zO
    • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687-97. doi: 10.1016/s0140-6736(10)61121-x.
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6
  • 20
    • 84862175196 scopus 로고    scopus 로고
    • Primary results from EMILIA, a phase III study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane
    • Blackwell K, Miles D, Gianni L. Primary results from EMILIA, a phase III study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane. J Clin Oncol. 2012;30(18 Suppl):810.
    • (2012) J Clin Oncol , vol.30 , Issue.18 SUPPL. , pp. 810
    • Blackwell, K.1    Miles, D.2    Gianni, L.3
  • 21
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • 10.1056/NEJMoa1011923 21561347 10.1056/NEJMoa1011923 1:CAS:528: DC%2BC3MXlvF2jsrw%3D
    • Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19):1817-25. doi: 10.1056/NEJMoa1011923.
    • (2011) N Engl J Med , vol.364 , Issue.19 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3    Bouche, O.4    Guimbaud, R.5    Becouarn, Y.6
  • 22
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • 10.1200/JCO.2006.07.9525 17452677 10.1200/JCO.2006.07.9525 1:CAS:528:DC%2BD2sXmvVWmsr0%3D
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25(15):1960-6. doi: 10.1200/JCO.2006.07.9525.
    • (2007) J Clin Oncol , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6
  • 23
    • 84864326095 scopus 로고    scopus 로고
    • From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets
    • 10.1038/nrc3299 22739505 10.1038/nrc3299 1:CAS:528:DC%2BC38XpsVWitLg%3D
    • Eifert C, Powers RS. From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets. Nat Rev Cancer. 2012;12(8):572-8. doi: 10.1038/nrc3299.
    • (2012) Nat Rev Cancer , vol.12 , Issue.8 , pp. 572-578
    • Eifert, C.1    Powers, R.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.