HFE gene C282Y variant is associated with colorectal cancer in Caucasians: A meta-analysis

Tumor Biology

Volumn 34, Issue 4, 2013, Pages 2255-2259

  Chen, Weidong ^a   Zhao, Hua ^a   Li, Tiegang ^a   Yao, Hongliang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Colorectal cancer; Hemochromatosis; HFE; Meta analysis; Variant

Indexed keywords

CYTOSINE; HEMOJUVELIN; TYROSINE;

ARTICLE; CANCER GENETICS; CAUCASIAN; COLORECTAL CANCER; CONTROLLED STUDY; GENE IDENTIFICATION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HFE GENE; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; SYSTEMATIC REVIEW;

EID: 84881474751     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0766-3     Document Type: Article

References (23)

1. Chua AC, Klopcic B, Lawrance IC, Olynyk JK, Trinder D. Iron: an emerging factor in colorectal carcinogenesis. World J Gastroenterol. 2010;16:663-72.
2. Bacon BR. Diagnosis and management of hemochromatosis. Gastroenterology. 1997;113:995-9.
3. Beutler E, Felitti V, Gelbart T, Ho N. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Ann Intern Med. 2000;133:329-37.
4. Beckman LE, Van Landeghem GF, Sikström C, Wahlin A, Markevärn B, Hallmans G, et al. Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders. Carcinogenesis. 1999;20:1231-3.
5. Shaheen NJ, Silverman LM, Keku T, Lawrence LB, Rohlfs EM, Martin CF, et al. Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. J Natl Cancer Inst. 2003;95:154-9.
6. Vander A DL, van der Hel O, Roest M, Vander Schouw YT, van Gils CH, Marx JJ, et al. Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands). Cancer Causes Control. 2003;14(6):541-5.
7. McGlynn KA, Sakoda LC, Hu Y, Schoen RE, Bresalier RS, Yeager M, et al. Hemochromatosis gene mutations and distal adenomatous colorectal polyps. Cancer Epidemiol Biomarkers Prev. 2005;14(1):158-63.
8. Robinson JP, Johnson VL, Rogers PA, Houlston RS, Maher ER, Bishop DT, et al. Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(6):1460-3.
9. Osborne NJ, Gurrin LC, Allen KJ, Constantine CC, Delatycki MB, McLaren CE, et al. HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology. 2010;51(4):1311-8.
10. Ekblom K, Marklund SL, Palmqvist R, Van Guelpen B, Hallmans G, Weinehall L, et al. Iron biomarkers in plasma, HFE genotypes, and the risk for colorectal cancer in a prospective setting. Dis Colon Rectum. 2012;55(3):337-44.
11. Asberg A, Thorstensen K, Irgens WØ, Romundstad PR, Hveem K. Cancer risk in HFE C282Y homozygotes: results from the HUNT 2 study. Scand J Gastroenterol. 2013;48(2):189-95.
12. Altés A, Gimferrer E, Capella G, Barceló MJ, Baiget M. Colorectal cancer and HFE gene mutations. Haematologica. 1999;84(5):479-80.
13. Macdonald GA, Tarish J, Whitehall VJ, McCann SJ, Mellick GD, Buttenshaw RL, et al. No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation. J Gastroenterol Hepatol. 1999;14(12):1188-91.
14. Shi Z, Johnstone D, Talseth-Palmer BA, Evans TJ, Spigelman AD, Groombridge C, et al. Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age. Int J Cancer. 2009;125(1):78-83.
15. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88.
16. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-48.
17. Fargion S, Valenti L, Fracanzani AL. Hemochromatosis gene (HFE) mutations and cancer risk: expanding the clinical manifestations of hereditary iron overload. Hepatology. 2010;51(4):1119-21.
18. Sullivan JL. Re: Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. J Natl Cancer Inst. 2003;95(11):829-30.
19. Chan AT, Ma J, Tranah GJ, Giovannucci EL, Rifai N, Hunter DJ, et al. Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. J Natl Cancer Inst. 2005;97(12):917-26.
20. Thaler RH. The winner's curse paradoxes and anomalies of economic life. Princeton, NJ: Princeton University Press; 1999.
21. Ellervik C, Birgens H, Tybjaerg-Hansen A, Nordestgaard BG. Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls. Hepatology. 2007;46(4):1071-80.
22. Jin F, Qu LS, Shen XZ. Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a meta-analysis. J Exp Clin Cancer Res. 2010;29:18.
23. Jin F, Xiong WJ, Jing JC, Feng Z, Qu LS, Shen XZ. Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review. J Cancer Res Clin Oncol. 2011;137(7):1095-104.