WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs

Stem Cell Reports

Volumn 1, Issue 1, 2013, Pages 46-52

  Jiang, Wei ^a,b,c   Zhang, Donghui ^e   Bursac, Nenad ^e   Zhang, Yi ^a,b,c,d  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; MESSENGER RNA; WNT3 PROTEIN; BIOLOGICAL MARKER; WNT3 PROTEIN, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINE; CELL LINEAGE; CELL STRUCTURE; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDODERM; GENE EXPRESSION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; PLURIPOTENT STEM CELL;

BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDODERM; HUMANS; INDUCED PLURIPOTENT STEM CELLS; RNA, MESSENGER; WNT3 PROTEIN;

EID: 84881469939     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2013.03.003     Document Type: Article

References (20)

1. C. Bock, E. Kiskinis, G. Verstappen, H. Gu, G. Boulting, Z.D. Smith, M. Ziller, G.F. Croft, M.W. Amoroso, and D.H. Oakley Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines Cell 144 2011 439 452
2. H.K. Bone, A.S. Nelson, C.E. Goldring, D. Tosh, and M.J. Welham A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 J. Cell Sci. 124 2011 1992 2000
3. L.A. Boyer, T.I. Lee, M.F. Cole, S.E. Johnstone, S.S. Levine, J.P. Zucker, M.G. Guenther, R.M. Kumar, H.L. Murray, and R.G. Jenner Core transcriptional regulatory circuitry in human embryonic stem cells Cell 122 2005 947 956
4. S. Brown, A. Teo, S. Pauklin, N. Hannan, C.H. Cho, B. Lim, L. Vardy, N.R. Dunn, M. Trotter, R. Pedersen, and L. Vallier Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors Stem Cells 29 2011 1176 1185
5. D.E. Cohen, and D. Melton Turning straw into gold: directing cell fate for regenerative medicine Nat. Rev. Genet. 12 2011 243 252
6. K.A. D'Amour, A.D. Agulnick, S. Eliazer, O.G. Kelly, E. Kroon, and E.E. Baetge Efficient differentiation of human embryonic stem cells to definitive endoderm Nat. Biotechnol. 23 2005 1534 1541
7. K.C. Davidson, A.M. Adams, J.M. Goodson, C.E. McDonald, J.C. Potter, J.D. Berndt, T.L. Biechele, R.J. Taylor, and R.T. Moon Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4 Proc. Natl. Acad. Sci. USA 109 2012 4485 4490
8. D.A. Elliott, S.R. Braam, K. Koutsis, E.S. Ng, R. Jenny, E.L. Lagerqvist, C. Biben, T. Hatzistavrou, C.E. Hirst, and Q.C. Yu NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes Nat. Methods 8 2011 1037 1040
9. D.C. Hay, J. Fletcher, C. Payne, J.D. Terrace, R.C. Gallagher, J. Snoeys, J.R. Black, D. Wojtacha, K. Samuel, and Z. Hannoun Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling Proc. Natl. Acad. Sci. USA 105 2008 12301 12306
10. W. Jiang, Y. Shi, D. Zhao, S. Chen, J. Yong, J. Zhang, T. Qing, X. Sun, P. Zhang, and M. Ding In vitro derivation of functional insulin-producing cells from human embryonic stem cells Cell Res. 17 2007 333 344
11. W. Jiang, J. Wang, and Y. Zhang Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway Cell Res. 23 2013 122 130
12. H. Kim, G. Lee, Y. Ganat, E.P. Papapetrou, I. Lipchina, N.D. Socci, M. Sadelain, and L. Studer miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells Cell Stem Cell 8 2011 695 706
13. J.K. Mfopou, B. Chen, L. Sui, K. Sermon, and L. Bouwens Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells Diabetes 59 2010 2094 2101
14. S.J. Micallef, X. Li, J.V. Schiesser, C.E. Hirst, Q.C. Yu, S.M. Lim, M.C. Nostro, D.A. Elliott, F. Sarangi, and L.C. Harrison INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells Diabetologia 55 2012 694 706
15. M.C. Nostro, F. Sarangi, S. Ogawa, A. Holtzinger, B. Corneo, X. Li, S.J. Micallef, I.H. Park, C. Basford, and M.B. Wheeler Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells Development 138 2011 861 871
16. K. Osafune, L. Caron, M. Borowiak, R.J. Martinez, C.S. Fitz-Gerald, Y. Sato, C.A. Cowan, K.R. Chien, and D.A. Melton Marked differences in differentiation propensity among human embryonic stem cell lines Nat. Biotechnol. 26 2008 313 315
17. Y. Pan, Z. Ouyang, W.H. Wong, and J.C. Baker A new FACS approach isolates hESC derived endoderm using transcription factors PLoS ONE 6 2011 e17536
18. D.A. Robinton, and G.Q. Daley The promise of induced pluripotent stem cells in research and therapy Nature 481 2012 295 305
19. C.A. Séguin, J.S. Draper, A. Nagy, and J. Rossant Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells Cell Stem Cell 3 2008 182 195
20. A.K. Teo, S.J. Arnold, M.W. Trotter, S. Brown, L.T. Ang, Z. Chng, E.J. Robertson, N.R. Dunn, and L. Vallier Pluripotency factors regulate definitive endoderm specification through eomesodermin Genes Dev. 25 2011 238 250