Hypophosphatemic Osteomalacia induced by low-dose adefovir therapy: Focus on manifestations in the skeletal system and literature review

Journal of Bone and Mineral Metabolism

Volumn 31, Issue 2, 2013, Pages 240-246

  Kim, Du Hwan ^a   Sung, Duk Hyun ^b   Min, Yong Ki ^b  

^a Keimyung University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Adefovir; Hypophosphatemia; Osteomalacia

Indexed keywords

25 HYDROXYVITAMIN D; ADEFOVIR DIPIVOXIL; ALBUMIN; ALKALINE PHOSPHATASE; CALCITRIOL; CARBOXY TERMINAL TELOPEPTIDE; CREATININE; ENTECAVIR; GLUCOSE; LAMIVUDINE; MEDRONATE TECHNETIUM TC 99M; PHOSPHATE; ADEFOVIR; ADENINE; DRUG DERIVATIVE; PHOSPHONIC ACID DERIVATIVE;

ADULT; BACK; BACKACHE; BODY HEIGHT; BODY WEIGHT; BONE BIOPSY; BONE DENSITOMETRY; BONE DENSITY; BONE PAIN; BONE SCINTISCANNING; BONE TURNOVER; CALCANEUS; CALLUS; CASE REPORT; COMPRESSION FRACTURE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; CREATININE BLOOD LEVEL; DRUG SUBSTITUTION; FEMUR; FOLLOW UP; GLOMERULUS FILTRATION RATE; GLUCOSE URINE LEVEL; HEPATITIS B; HUMAN; HYPOPHOSPHATEMIC RICKETS; HYPOURICEMIA; ILIAC BONE; KNEE; KNEE PAIN; LIVER CIRRHOSIS; LOW DRUG DOSE; MALE; MEDICAL HISTORY; METABOLIC BONE DISEASE; METATARSOPHALANGEAL JOINT; MICROALBUMINURIA; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOMALACIA; PELVIC GIRDLE; PHOSPHATE URINE LEVEL; PRIORITY JOURNAL; REVIEW; RIB; RIB FRACTURE; SACROILIAC JOINT; SACRUM; SITTING; SKELETON; SLEEP; SNEEZING; SPINE; SUPPLEMENTATION; TARSAL BONE; THORACIC SPINE; THORAX DEFORMITY; THORAX WALL; TIBIA; TREATMENT REFUSAL; URINALYSIS; VIRUS RESISTANCE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WALKING; BONE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; HYPOPHOSPHATEMIA; PATHOLOGY; RADIOGRAPHY; SCINTISCANNING;

ADENINE; BONE AND BONES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOPHOSPHATEMIA; MALE; MIDDLE AGED; ORGANOPHOSPHONATES; OSTEOMALACIA; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84881462455     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-012-0384-y     Document Type: Review

References (20)

1. Minemura M, Tokimitsu Y, Tajiri K, Nakayama Y, Kawai K, Kudo H, Hirano K, Atarashi Y, Yata Y, Yasumura S, Takahara T, Sugiyama T (2010) Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil. World J Hepatol 2:442-446
2. Girgis CM, Wong T, Ngu MC, Emmett L, Archer KA, Chen RC, Seibel MJ (2011) Hypophosphataemic osteomalacia in patients on adefovir dipivoxil. J Clin Gastroenterol 45:468-473
3. Tanji N, Tanji K, Kambham N, Markowitz GS, Bell A, D'Agati VD (2001) Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Hum Pathol 32:734-740
4. Izzedine H, Hulot JS, Launay-Vacher V, Marcellini P, Hadziyannis SJ, Currie G, Brosgart CL, Westland C, Arterbrun S, Deray G (2004) Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebocontrolled studies. Kidney Int 66:1153-1158
5. Fabbriciani G, de Socio GV, Massarotti M, Ceriani R, Marasini B (2011) Adefovir induced hypophosphatemic osteomalacia. Scand J Infect Dis 43:990-992
6. Carpenter TO (2012) The expanding family of hypophosphatemic syndromes. J Bone Miner Metab 30:1-9
7. Gifre L, Peris P, Monegal A, Martinez de Osaba MJ, Alvarez L, Guanabens N (2011) Osteomalacia revisited: a report on 28 cases. Clin Rheumatol 30:639-645
8. Reginato AJ, Coquia JA (2003) Musculoskeletal manifestations of osteomalacia and rickets. Best Pract Res Clin Rheumatol 17:1063-1080
9. Kwon SY, Ahn SY, Ko SY, Jang YM, Choi YH, Kim BK, Choe WH, Lee CH (2010) A case of osteomalacia related to adefovir in a patient with chronic hepatitis B. Korean J Gastroenterol 56:117-120
10. Lee HJ, Choi JW, Kim TN, Eun JR (2008) A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus. Korean J Hepatol 14:381-386
11. Earle KE, Seneviratne T, Shaker J, Shoback D (2004) Fanconi's syndrome in HIV? adults: report of three cases and literature review. J Bone Miner Res 19:714-721
12. Izzedine H, Kheder-Elfekih R, Housset P, Sarkozy C, Brocheriou I, Deray G (2009) Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient. AIDS 23:544-545
13. Jung YK, Yeon JE, Choi JH, Kim CH, Jung ES, Kim JH, Park JJ, Kim JS, Bak YT, Byun KS (2010) Fanconi's syndrome associated with prolonged adefovir dipivoxil therapy in a hepatitis B virus patient. Gut Liver 4:389-393
14. Kawate H, Taketomi A, Watanabe T, Nomura M, Kato M, Sakamoto R, Ikegami T, Soejima Y, Maehara Y, Takayanagi R (2011) Hypophosphatemic osteomalacia as a long-term complication after liver transplantation. Transplantation 91:e6-e8
15. Wong T, Girgis CM, Ngu MC, Chen RC, Emmett L, Archer KA, Seibel MJ (2010) Hypophosphatemic osteomalacia after lowdose adefovir dipivoxil therapy for hepatitis B. J Clin Endocrinol Metab 95:479-480
16. Reginato AJ, Falasca GF, Pappu R, McKnight B, Agha A (1999) Musculoskeletal manifestations of osteomalacia: report of 26 cases and literature review. Semin Arthritis Rheum 28:287-304
17. Luxon BA (2011) Bone disorders in chronic liver diseases. Curr Gastroenterol Rep 13:40-48
18. Berry JL, Davies M, Mee AP (2002) Vitamin D metabolism, rickets, and osteomalacia. Semin Musculoskelet Radiol 6:173-182
19. Fogelman I, McKillop JH, Bessent RG, Boyle IT, Turner JG, Greig WR (1978) The role of bone scanning in osteomalacia. J Nucl Med 19:245-248
20. Hain SF, Fogelman I (2002) Nuclear medicine studies in metabolic bone disease. Semin Musculoskelet Radiol 6:323-329