Interferon-γ inhibits integrin-mediated extracellular signal-regulated kinase activation stimulated by fibronectin binding in thyroid cells

Journal of Endocrinological Investigation

Volumn 36, Issue 6, 2013, Pages 375-378

  Russo, E ^a   Salzano, M ^a   Postiglione, L ^a   Guerra, A ^b   Marotta, V ^a   Vitale, M ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Integrins; Interferon; Thyroid cells

Indexed keywords

FIBRONECTIN; GAMMA INTERFERON; INTEGRIN; INTERLEUKIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; VERY LATE ACTIVATION ANTIGEN 3; VITRONECTIN RECEPTOR;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; INTRACELLULAR SIGNALING; PROTEIN PHOSPHORYLATION; THYROID CELL; WESTERN BLOTTING;

CELL ADHESION; CYTOKINES; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRONECTINS; HUMANS; INTEGRINS; INTERFERON-GAMMA; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, FIBRONECTIN; THYROID GLAND; TUMOR CELLS, CULTURED;

EID: 84881448817     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/8649     Document Type: Article

References (28)

1. Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977, 7: 481-93.
2. Tunbridge WM, Brewis M, French JM, et al. Natural history of autoimmune thyroiditis. Br Med J (Clin Res Ed) 1981, 282: 258-62.
3. Caturegli P, Kimura H, Rocchi R, Rose NR. Autoimmune thyroid diseases. Curr Opin Rheumatol 2007, 19: 44-8.
4. Stassi G, Di Liberto D, Todaro M, et al. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Nat Immunol 2000, 1: 483-8.
5. Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995, 16: 34-8.
6. Roura-Mir C, Catalfamo M, Cheng TY, et al. CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis. J Immunol 2005, 174: 3773-80.
7. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994, 12: 227-57.
8. Carter LL, Dutton RW. Type 1 and type 2: a fundamental dichotomy for all T-cell subsets. Curr Opin Immunol 1996, 8: 336-42.
9. Stassi G, Zeuner A, Di Liberto D, et al. Fas-FasL in Hashimoto's thyroiditis. J Clin Immunol 2001, 21: 19-23.
10. Roura-Mir C, Catalfamo M, Sospedra M, et al. Single-cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto's and Graves' disease. Eur J Immunol 1997, 27: 3290-302.
11. Otey CA, Pavalko FM, Burridge K. An interaction between alphaactinin and the beta 1 integrin subunit in vitro. J Cell Biol 1990, 111: 721-9.
12. Luna EJ, Hitt AL. Cytoskeleton-plasma membrane interactions. Science 1992, 258: 955-64.
13. Pasqualini R, Hemler ME. Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol 1994, 125: 447-60.
14. Mortarini R, Gismondi A, Santoni A, Parmiani G, Anichini A. Role of the alpha 5 beta 1 integrin receptor in the proliferative response of quiescent human melanoma cells to fibronectin. Cancer Res 1992, 52: 4499-506.
15. Vitale M, Bassi V, Illario M, et al. Loss of polarity and de novo expression of the beta 1 family of integrins in thyroid tumors. Int J Cancer 1994, 59: 185-90.
16. Vitale M, Casamassima A, Illario M, et al. Cell-to-cell contact modulates the expression of the beta 1 family of integrins in primary cultures of thyroid cells. Exp Cell Res 1995, 220: 124-9.
17. Wilkins JA, Stupack D, Stewart S, Caixia S. Beta 1 integrin-mediated lymphocyte adherence to extracellular matrix is enhanced by phorbol ester treatment. Eur J Immunol 1991, 21: 517-22.
18. Vitale M, Bassi V, Fenzi G, et al. Integrin expression in thyroid cells from normal glands and nodular goiters. J Clin Endocrinol Metab 1993, 76: 1575-9.
19. Illario M, Amideo V, Casamassima A, et al. Integrin-dependent cell growth and survival are mediated by different signals in thyroid cells. J Clin Endocrinol Metab 2003, 88: 260-9.
20. Vitale M, Di Matola T, Fenzi G, Illario M, Rossi G. Fibronectin is required to prevent thyroid cell apoptosis through an integrin-mediated adhesion mechanism. J Clin Endocrinol Metab 1998, 83: 3673-80.
21. Di Matola T, Mueller F, Fenzi G, et al. Serum withdrawal-induced apoptosis in thyroid cells is caused by loss of fibronectin-integrin interaction. J Clin Endocrinol Metab 2000, 85: 1188-93.
22. Vitale M, Illario M, Di Matola T, et al. Integrin binding to immobilized collagen and fibronectin stimulates the proliferation of human thyroid cells in culture. Endocrinology 1997, 138: 1642-8.
23. Phenekos C, Vryonidou A, Gritzapis AD, et al. Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto's thyroiditis (Th1) and Graves' disease (Th2). Neuroimmunomodulation 2004, 11: 209-13.
24. Yu S, Sharp GC, Braley-Mullen H. Thyrocytes responding to IFNgamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia. J Immunol 2006, 176: 1259-65.
25. Weetman AP The potential immunological role of the thyroid cell in autoimmune thyroid disease. Thyroid 1994, 4: 493-9.
26. Caturegli P, Hejazi M, Suzuki K, et al. Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid. Proc Natl Acad Sci U S A 2000, 97: 1719-24.
27. Illario M, Cavallo AL, Monaco S, et al. Fibronectin-Induced proliferation in thyroid cells is mediated by αvβ3 integrin through Ras/Raf-1/MEK/ERK and calcium/CaMKII signals. J Clin Endocrinol Metab 2005, 90: 2865-73.
28. Vitale M, Di Matola T, Bifulco M, et al. Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression. FEBS Lett 1999, 462: 57-60.