Inhibitory effects of tocopherols on expression of the cyclooxygenase-2 gene in RAW264.7 cells stimulated by lipopolysaccharide, tumor necrosis factor-α or Porphyromonas gingivalis fimbriae

In Vivo

Volumn 27, Issue 4, 2013, Pages 451-458

  Murakami, Yukio ^a   Kawata, Akifumi ^a   Koh, Teho ^a   Seki, Yuya ^a   Tamura, Seiko ^a   Katayama, Tadashi ^a   Fujisawa, Seiichiro ^a  

^a MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

COX2 mRNA expression; LPS; Porphyromonas gingivalis fimbriae; RAW264.7 cells; TNF ; Tocopherols

Indexed keywords

ALPHA TOCOPHEROL; BETA TOCOPHEROL; CYCLOOXYGENASE 2; DELTA TOCOPHEROL; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA TOCOPHEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENZYME INHIBITION; MACROPHAGE; MOUSE; NONHUMAN; PORPHYROMONAS GINGIVALIS; PROTEIN EXPRESSION;

EID: 84881432663     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Burton GW and Ingold KU: Autoxidation of biological molecules. 1. The antioxidant activity of vitamin E and related chain-breaking phenolic antioxidant in vitro. J Am chem Soc 110: 2224-2229, 1988.
2. Parrish JH Jr., DeMarco TJ and Bissada NF: Vitamin E and periodontitis in the rat. Oral Surg Oral Med Oral Pathol 44: 210-218, 1977.
3. Slade EW Jr., Bartuska D, Rose LF and Cohen DW: Vitamin E and periodontal disease. J Periodontol 47: 352-354, 1977.
4. Cohen ME and Meyer DM: Effect of dietary vitamin E supplementation and rotational stress on alveolar bone loss in rice rats. Arch Oral Biol 38: 601-606, 1993.
5. Iwasaki M, Manz MC, Taylor GW, Yoshihara A and Miyazaki H: Relations of serum ascorbic acid and α-tocopherol to periodontal disease. J Dent Res 91: 167-172, 2012.
6. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB and Lipsky PE: Cyclooxygenase in biology and disease. FASEB J 12: 1063-1073, 1998.
7. Vane JR and Botting RM: Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47(Suppl 2): S78-87, 1998.
8. Gupta RA and Dubois RN: Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 1: 11-21, 2001.
9. Eliopoulos AG, Dumitru CD, Wang CC, Cho J and Tsichlis PN: Induction of COX2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J 21: 4831-4840, 2002.
10. Murakami Y, Shoji M, Hirata A, Tanaka S, Yokoe I and Fujisawa S: Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages. Arch Biochem Biophys 434: 326-332, 2005.
11. Yoshimura F, Takahashi K, Nodasaka Y and Suzuki T: Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis. J Bacteriol 160: 949-954, 1984.
12. Hanazawa S, Murakami Y, Hirose K, Amano S, Ohmori Y, Higuchi H and Kitano S: Bacteroides (Porphyromonas) gingivalis fimbriae activating mouse peritoneal macrophages and gene expression and production of interleukin-1. Infect Immun 59: 1972-1977, 1991.
13. Hanazawa S, Kawata Y, Murakami Y, Naganuma K, Amano S, Miyata Y and Kitano S: Porphyromonas gingivalis fimbriastimulated bone resorption in vitro is inhibited by a tyrosine kinase inhibitor. Infect Immun 63: 2374-2377, 1995.
14. Murakami Y, Shoji M, Hirata A, Tanaka S, Hanazawa S, Yokoe I and Fujisawa S: An ortho dimer of butylated hydroxyanisole inhibits nuclear factor kappa B activation and gene expression of inflammatory cytokines in macrophages stimulated by Porphyromonas gingivalis fimbriae. Arch Biochem Biophys 449: 171-177, 2006.
15. Murakami Y, Shoji M, Ogiwara T, Tanaka S, Yokoe I and Fujisawa S: Preventive effect of ortho dimer of butylated hydroxyanisole on activator protein-1 activation and cyclooxygenase-2 expression in macrophages stimulated by fimbriae of Porphyromonas gingivalis, an oral anaerobe. Anticancer Res 26: 2915-2920, 2006.
16. Murakami Y, Kawata A, Seki Y, Koh T, Yuhara K, Maruyama T, Machino M, Ito S, Kadoma Y and Fujisawa S: Comparative inhibitory effects of magnolol, honokiol, eugenol and biseugenol on cyclooxygenase-2 expression and nuclear factor kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis. In Vivo 26: 941-950, 2012.
17. Ishiyama M, Miyazono Y, Sasamoto K, Ohkura Y and Ueno K: A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Talanta 44: 1299-1305, 1997.
18. Smith PM, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
19. Abate A, Yang G, Dennery PA, Oberle S and Schroder H: Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. Free Radic Biol Med 29: 1135-1142, 2000.
20. Egger T, Schuligoi R, Wintersperger A, Amann R, Malle E and Sattler W: Vitamin E (α-tocopherol) attenuates cyclooxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia. Biochem J 370: 459-467, 2003.
21. Jiang Q, Yin X, Lill MA, Danielson ML, Freiser H and Huang J: Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. Proc Natl Acad Sci USA 105: 20464-20469, 2008.
22. Guan F, Li G, Liu AB, Lee MJ, Yang Z, Chen YK, Lin Y, Shih W and Yang CS: δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats. Cancer Prev Res 5: 644-654, 2012.
23. Jiang Q, Christen S, Shigenaga MK and Ames BN: γ- Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74: 714-722, 2001.
24. Brigelius-Flohe R and Traber MG. Vitamin E: function and metabolism. FASEB J 13: 1145-1155, 1999.
25. Lu Y and Wahl LM: Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NFκB activity in lipopolysaccharide-activated human primary monocytes. J Immunol 175: 5423-5429, 2005.
26. Pryor WA, Strickland T and Church, DF: Comparison of the efficiency of several natural and synthetic antioxidants in aqueous sodium dodecyl sulpfate micelle solutions. J Am Chem Soc 110: 2224-2229. 1988.
27. Fujisawa S and Kadoma Y: Kinetic study of the radicalscavenging activity of vitamin E and ubiquinone. In Vivo 19: 1005-1012, 2005.
28. Zingg JM and Azzi A: Non-antioxidant activities of vitamin E. Curr Med Chem 11: 1113-1133, 2004.
29. Azzi A, Gysin R, Kempna P, Munteanu A, Negis Y, Villacorta L, Visarius T and Zingg JM: Vitamin E mediates cell signaling and regulation of gene expression. Ann NY Acad Sci 1031: 86-95, 2004.
30. Azzi A, Breyer I, Feher M, Pastori M, Ricciarelli R, Spycher S, Staffieri M, Stocker A, Zimmer S and Zingg JM: Specific cellular responses to alpha-tocopherol. J Nutr 30: 1649-1652, 2000.
31. Rimbach G, Moehring J, Huebbe P and Lodge JK: Generegulatory activity of alpha-tocopherol. Molecules 15: 1746-1761, 2010.
32. Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA and Croce CM: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179: 5082-5089, 2007.
33. Lim Y, Vasu VT, Valacchi G, Leonard S, Aung HH, Schock BC, Kenyon NJ, Li CS, Traber MG and Cross CE: Severe vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model. Free Radic Res 42: 387-396, 2008.
34. Yamaoka S, Kim HS, Ogihara T, Oue S, Takitani K, Yoshida Y and Tamai H: Severe Vitamin E deficiency exacerbates acute hyperoxic lung injury associated with increased oxidative stress and inflammation. Free Radic Res 42: 602-612, 2008.
35. Murakami Y, Hanazawa S, Nishida K, Iwasaka H and Kitano S: N-acetyl-D-galactosamine inhibits TNF-α gene expression induced in mouse peritonal macrophages by fimbriae of Porphyromonas (Bacteroides) gingivalis, an oral anaerobe. Biochem Biophys Res Commun 192: 826-832, 1993.