Partial manual exchange reduces iron accumulation during chronic red cell transfusions for sickle cell disease

Journal of Pediatric Hematology/Oncology

Volumn 35, Issue 6, 2013, Pages 434-436

  Savage, William J ^a   Reddoch, Shirley ^b   Wolfe, Jaime ^c   Casella, James F ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

ferritin; iron; iron loading; sickle cell; transfusion

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON;

ACUTE CHEST SYNDROME; ADOLESCENT; ARTICLE; BODY MASS; CEREBROVASCULAR ACCIDENT; CHELATION THERAPY; CHILD; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CYTAPHERESIS; ERYTHROCYTE TRANSFUSION; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; INFANT; INTRACTABLE PAIN; IRON CHELATION; IRON OVERLOAD; IRON STORAGE; LONG TERM CARE; LUNG INFECTION; MALE; PHLEBOTOMY; PRESCHOOL CHILD; PRIMARY PREVENTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SCHOOL CHILD; SECONDARY PREVENTION; SICKLE CELL ANEMIA; TREATMENT INDICATION;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; ERYTHROCYTE TRANSFUSION; FEMALE; HUMANS; IRON OVERLOAD; MALE; MIDDLE AGED; PHLEBOTOMY; YOUNG ADULT;

EID: 84881421476     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31829d470d     Document Type: Article

References (17)

1. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339:5-11.
2. Adams RJ, Brambilla D. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med. 2005;353:2769-2778.
3. Jordan LC, Casella JF, Debaun MR. Prospects for primary stroke prevention in children with sickle cell anaemia. Br J Haematol. 2012;157:14-25.
4. Casella JF, King AA, Barton B, et al. Design of the silent cerebral infarct transfusion (SIT) trial. Pediatr Hematol Oncol. 2010;27:69-89.
5. Cho G, Hambleton IR. Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease. Cochrane Database Syst Rev. 2011;9:CD008360.
6. Angelucci E, Brittenham GM,McLaren CE, et al. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med. 2000;343:327-331.
7. Harmatz P, Butensky E, Quirolo K, et al. Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy. Blood. 2000;96:76-79.
8. Fung EB, Harmatz PR, Lee PD, et al. Increased prevalence of iron-overload associated endocrinopathy in thalassaemia versus sickle-cell disease. Br J Haematol. 2006;135:574-582.
9. Kim HC, Dugan NP, Silber JH, et al. Erythrocytapheresis therapy to reduce iron overload in chronically transfused patients with sickle cell disease. Blood. 1994;83:1136-1142.
10. Singer ST, Quirolo K, Nishi K, et al. Erythrocytapheresis for chronically transfused children with sickle cell disease: an effective method for maintaining a low hemoglobin S level and reducing iron overload. J Clin Apher. 1999;14:122-125.
11. Adams DM, Schultz WH, Ware RE, et al. Erythrocytapheresis can reduce iron overload and prevent the need for chelation therapy in chronically transfused pediatric patients. J Pediatr Hematol Oncol. 1996;18:46-50.
12. Hilliard LM, Williams BF, Lounsbury AE, et al. Erythrocytapheresis limits iron accumulation in chronically transfused sickle cell patients. Am J Hematol. 1998;59:28-35.
13. Karafin MS, Shirey RS, Ness PM, et al. Antigen-matched red blood cell transfusions for patients with sickle cell disease at The Johns Hopkins Hospital. Immunohematology. 2012;28:3-6.
14. Adamkiewicz TV, Abboud MR, Paley C, et al. Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are non-linear, and are associated with iron load and liver injury. Blood. 2009;114:4632-4638.
15. Karam LB, Disco D, Jackson SM, et al. Liver biopsy results in patients with sickle cell disease on chronic transfusions: poor correlation with ferritin levels. Pediatr Blood Cancer. 2008;50: 62-65.
16. Brittenham GM, Cohen AR, McLaren CE, et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol. 1993;42: 81-85.
17. Inati A, Musallam KM, Wood JC, et al. Iron overload indices rise linearly with transfusion rate in patients with sickle cell disease. Blood. 2010;115:2980-2981, author reply 2981-2982.