Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury

Blood

Volumn 114, Issue 21, 2009, Pages 4632-4638

  Adamkiewicz, Thomas V ^a   Abboud, Miguel R ^b,c   Paley, Carole ^d   Olivieri, Nancy ^e   Kirby Allen, Melanie ^e   Vichinsky, Elliott ^f   Casella, James F ^g   Alvarez, Ofelia A ^h   Barredo, Julio C ^b,h   Lee, Margaret T ⁱ   Iyer, Rathi V ^j   Kutlar, Abdullah ^k   McKie, Kathleen M ^k   McKie, Virgil ^k   Odo, Nadine ^k   Gee, Beatrice ^a   Kwiatkowski, Janet L ^l   Woods, Gerald M ^m   Coates, Thomas ⁿ   Wang, Winfred ^o   Adams, Robert J ^b,k   more..

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF TORONTO   (Canada)

^f CHILDREN S HOSPITAL OAKLAND   (United States)

^g JOHNS HOPKINS UNIVERSITY   (United States)

^h UNIVERSITY OF MIAMI   (United States)

ⁱ Och Spine at New York Presbyterian Hospitals   (United States)

^j UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^k MEDICAL COLLEGE OF GEORGIA   (United States)

^l CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^m CHILDREN S MERCY HOSPITAL   (United States)

ⁿ CHILDREN S HOSPITAL LOS ANGELES   (United States)

^o ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; DEFEROXAMINE; FERRITIN; IRON; SIDEROPHORE;

ARTICLE; BLOOD TRANSFUSION; CHELATION; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; IRON OVERLOAD; LIVER INJURY; LIVER LEVEL; LIVER WEIGHT; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SICKLE CELL ANEMIA; STROKE; AREA UNDER THE CURVE; BLOOD; CONTROLLED CLINICAL TRIAL; LIVER; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; RECEIVER OPERATING CHARACTERISTIC;

ALANINE TRANSAMINASE; ANEMIA, SICKLE CELL; AREA UNDER CURVE; BLOOD TRANSFUSION; CHILD; DEFEROXAMINE; FERRITINS; HUMANS; IRON OVERLOAD; LIVER; LIVER CIRRHOSIS; ROC CURVE; SIDEROPHORES; STROKE;

EID: 73949153192     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-02-203323     Document Type: Article

References (47)

1. Vichinsky E. Oral iron chelators and the treatment of iron overload in pediatric patients with chronic anemia. Pediatrics. 2008;121(6):1253-1256.
2. Kim HC, Dugan NP, Silber JH, et al. Erythrocytapheresis therapy to reduce iron overload in chronically transfused patients with sickle cell disease. Blood. 1994;83(4):1136-1142.
3. Olivieri NF, Nathan DG, MacMillan JH, et al. Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med. 1994;331:574-578.
4. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology. 1975; 68(3):525-533.
5. Worwood M, Cragg SJ, Jacobs A, McLaren C, Ricketts C, Economidou J. Binding of serum ferritin to concanavalin A: patients with homozygous beta thalassaemia and transfusional iron overload. Br J Haematol. 1980;46(3):409-416.
6. Aldouri MA, Wonke B, Hoffbrand AV, et al. Iron state and hepatic disease in patients with thalassaemia major, treated with long term subcutaneous desferrioxamine. J Clin Pathol. 1987;40(11): 1353-1359.
7. Brittenham GM, Cohen AR, McLaren CE, et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol. 1993;42(1):81-85.
8. Mazza P, Giua R, De Marco S, et al. Iron overload in thalassemia: comparative analysis of magnetic resonance imaging, serum ferritin and iron content of the liver. Haematologica. 1995;80(5):398-404.
9. Harmatz P, Butensky E, Quirolo K, et al. Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy. Blood. 2000;96(1):76-79.
10. Angelucci E, Brittenham GM, McLaren CE, et al. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med. 2000; 343(5):327-331.
11. Files B, Brambilla D, Kutlar A, et al. Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). J Pediatr Hematol Oncol. 2002;24(4):284-290.
12. Karam LB, Disco D, Jackson SM, et al. Liver biopsy results in patients with sickle cell disease on chronic transfusions: poor correlation with ferritin levels. Pediatr Blood Cancer. 2008;50(1):62-65.
13. Brownell A, Lowson S, Brozovic M. Serum ferritin concentration in sickle cell crisis. J Clin Pathol. 1986;39(3):253-255.
14. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339(1):5-11.
15. Adams RJ, Brambilla D. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med. 2005;353(26):2769-2778.
16. Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet. 2007; 370(9585):415-426.
17. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood. 1997(3):89:739-761.
18. Bush VJ, Moyer TP, Batts KP, Parisi JE. Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues. Clin Chem. 1995;41(2):284-294.
19. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22(6):696-699.
20. Stegun I, ed. Probability functions. In: Handbook of Mathematical Functions With Formulas, Graphs, and Mathematical Tables. Washington, DC: US Department of Commerce National Bureau of Standards; 1964:946.
21. Bewick V, Cheek L, Ball J. Statistics review 13: receiver operating characteristic curves. Crit Care. 2004;8(6):508-512.
22. Efron B, Tibshirani RJ. An Introduction to Boostrap. Boca Raton, FL: Chapman & Hall/CRC Press; 1993.
23. Littell RC, Milliken GA, Stroup WW, Wolfinger RD, Schabenberber O. SAS for Mixed Models. Cary, NC: SAS Institute; 2006.
24. Chasteen ND, Harrison PM. Mineralization in ferritin: an efficient means of iron storage. J Struct Biol. 1999;126(3):182-194.
25. Sammarco MC, Ditch S, Banerjee A, Grabczyk E. Ferritin L and H subunits are differentially regulated on a post-transcriptional level. J Biol Chem. 2008;283(8):4578-4587.
26. Miyazaki E, Kato J, Kobune M, et al. Denatured H-ferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload. Gut. 2002;50(3):413-419.
27. Luzzago A, Arosio P, Iacobello C, et al. Immunochemical characterization of human liver and heart ferritins with monoclonal antibodies. Biochim Biophys Acta. 1986;872(1):61-71.
28. Ghosh S, Hevi S, Chuck SL. Regulated secretion of glycosylated human ferritin from hepatocytes. Blood. 2004;103(6):2369-2376.
29. Ward C, Saltman P, Ripley L, et al. Correlation of serum ferritin and liver ferritin iron in the anemic, normal, iron-loaded rat. Am J Clin Nutr. 1977; 30(7):1054-1063.
30. Chan YL, Li CK, Chik KW, Law MY, Howard R. Liver volume in thalassaemia major: relationship with body weight, serum ferritin, and liver function. Pediatr Radiol. 2005;35(2):165-168.
31. Jensen PD, Jensen FT, Christensen T, Nielsen JL, Ellegaard J. Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients with acquired anemias. Blood. 2003;101(1):91-96.
32. Chapman RW, Hussain MA, Gorman A, et al. Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. J Clin Pathol. 1982; 35(5):487-491.
33. Maciel P, Cruz VT, Constante M, et al. Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement. Neurology. 2005;65(4):603-605.
34. Garcia-Arias MB, Rodriguez-Galindo C, Hoffer FA, Wang WC. Pyogenic hepatic abscess after percutaneous liver biopsy in a patient with sickle cell disease. J Pediatr Hematol Oncol. 2005; 27(2):103-105.
35. Zakaria N, Knisely A, Portmann B, et al. Acute sickle cell hepatopathy represents a potential contraindication for percutaneous liver biopsy. Blood. 2003;101(1):101-103.
36. Butensky E, Fischer R, Hudes M, et al. Variability in hepatic iron concentration in percutaneous needle biopsy specimens from patients with transfusional hemosiderosis. Am J Clin Pathol. 2005;123(1):146-152.
37. Barry M. Determination of chelated iron in the liver. J Clin Pathol. 1968(21):166-168.
38. Pippard MJ. Iron loading and chelation therapy. In: Weatherall DJ, ed. The Thalassemias. Methods in Hematology, Vol 6. Edinburgh, United Kingdom: Churchill Livingstone; 1983:103-113.
39. Soriano-Cubells MJ, Aparisi-Querada L. Rapid determination of copper, iron and zinc in liver biopsies. Atomic Spectrosc. 1984;5(6):217-222.
40. Angelucci E, Muretto P, Lucarelli G, et al. Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation: Italian Cooperative Group for Phlebotomy Treatment of Transplanted Thalassemia Patients. Blood. 1997;90:994-998.
41. Nielsen P, Engelhardt R, Dullmann J, Fischer R. Non-invasive liver iron quantification by SQUID-biosusceptometry and serum ferritin iron as new diagnostic parameters in hereditary hemochromatosis. Blood Cells Mol Dis. 2002;29(3):451-458.
42. St Pierre TG, Clark PR, Chua-anusorn W, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood. 2005;105(2):855-861.
43. Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005;106(6):1460-1465.
44. Noetzli LJ, Carson SM, Nord AS, Coates TD, Wood JC. Longitudinal analysis of heart and liver iron in thalassemia major. Blood. 2008;112(7): 2973-2978.
45. Hankins JS, McCarville MB, Loeffler RB, et al. R2* magnetic resonance imaging of the liver in patients with iron overload. Blood. 2009;113(20): 4853-4855.
46. Cohen B, Ziv K, Plaks V, Harmelin A, Neeman M. Ferritin nanoparticles as magnetic resonance reporter gene. Nanomed Nanobiotechnol. 2009; 1(2):181-188.
47. Fung EB, Harmatz P, Milet M, et al. Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: a report from the multicenter study of iron overload. Am J Hematol. 2007;82(4):255-265.