Nanoporous silica coatings as a drug delivery system for ciprofloxacin: Outcome of variable release rates in the infected middle ear of rabbits

Otology and Neurotology

Volumn 34, Issue 6, 2013, Pages 1138-1145

  Hesse, Daniela ^a   Ehlert, Nina ^b   Lüenhop, Tammo ^b   Smoczek, Anna ^a   Glage, Silke ^a   Behrens, Peter ^b   Müller, Peter Paul ^c   Esser, Karl Heinz ^d   Lenarz, Thomas ^a   Stieve, Martin ^a   Bleich, André ^b   Prenzler, Nils Kristian ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Drug delivery system; Middle ear prostheses; Nanoporous silica layer; Pseudomonas aeruginosa; Rabbit

Indexed keywords

ANTIINFECTIVE AGENT; CERAMICS; CIPROFLOXACIN; DELAYED RELEASE FORMULATION; DRUG IMPLANT; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL; ANIMAL BEHAVIOR; CERAMICS; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG IMPLANT; EAR DISEASES; FEMALE; KAPLAN MEIER METHOD; MATERIALS TESTING; MICROBIOLOGY; MIDDLE EAR; NEUROLOGIC EXAMINATION; PHYSIOLOGY; PSEUDOMONAS INFECTIONS; RABBIT; SURGERY; SURVIVAL; ARTICLE; EAR DISEASE; PSEUDOMONAS INFECTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BEHAVIOR, ANIMAL; CERAMICS; CIPROFLOXACIN; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; EAR DISEASES; EAR, MIDDLE; FEMALE; KAPLAN-MEIER ESTIMATE; MATERIALS TESTING; NANOPARTICLES; NEUROLOGIC EXAMINATION; PSEUDOMONAS INFECTIONS; RABBITS; SILICON DIOXIDE; SURVIVAL ANALYSIS;

EID: 84881377398     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e3182839671     Document Type: Article

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