Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: An animal study in rabbits

Acta Biomaterialia

Volumn 9, Issue 1, 2013, Pages 4815-4825

  Lensing, Rebecca ^a   Bleich, André ^a   Smoczek, Anna ^a   Glage, Silke ^a   Ehlert, Nina ^b   Luessenhop, Tammo ^b   Behrens, Peter ^b   Müller, Peter Paul ^c   Kietzmann, Manfred ^d   Stieve, Martin ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Animal model; Drug release; Infection; Middle ear; Nanoporous

Indexed keywords

ANIMALS; COATINGS; CONTROLLED DRUG DELIVERY; PROSTHETICS; SILICA; TARGETED DRUG DELIVERY;

ANIMAL MODEL; CONTROL GROUPS; DELIVERY SYSTEMS; DRUG RELEASE; INFECTION; MIDDLE EARS; NANO-POROUS; NANOPOROUS SILICA COATINGS; OTITIS MEDIA; STUDY GROUPS;

ANTIBIOTICS;

CIPROFLOXACIN; NANOCOATING; SILICON DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM DETECTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; EXPERIMENTAL RABBIT; FEMALE; IN VIVO STUDY; INOCULATION; MIDDLE EAR; MIDDLE EAR PROSTHESIS; MIDDLE EAR SURGERY; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS; PSEUDOMONAS AERUGINOSA;

EID: 84870240626     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.08.016     Document Type: Article

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