Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5′-GCGC-3′

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5436-5441

  Han, Yong Woon ^a,d   Kashiwazaki, Gengo ^b   Morinaga, Hironobu ^b   Matsumoto, Tomoko ^a,c   Hashiya, Kaori ^b   Bando, Toshikazu ^b   Harada, Yoshie ^a   Sugiyama, Hiroshi ^a,c,d  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

DNA binding small molecule; Polyamide; Pyrrole imidazole polyamide; Sequence specificity

Indexed keywords

BETA ALANINE BETA ALANINE N METHYLIMIDAZOLE BETA ALANINE N METHYLIMIDAZOLE N METHYLPYRROLE GAMMA AMINOBUTYRIC ACID N METHYLIMIDAZOLE N METHYLPYRROLE BETA ALANINE[((DIMETHYLAMINO)PROPYL)AMIDE]; BETA ALANINE BETA ALANINE N METHYLIMIDAZOLE BETA ALANINE N METHYLIMIDAZOLE N METHYLPYRROLE GAMMA AMINOBUTYRIC ACID N METHYLIMIDAZOLE N METHYLPYRROLE N METHYLIMIDAZOLE N METHYLPYRROLE BETA ALANINE[((DIMETHYLAMINO)PROPYL)AMIDE]; BETA ALANINE BETA ALANINE N METHYLIMIDAZOLE N METHYLPYRROLE N METHYLIMIDAZOLE N METHYLPYRROLE GAMMA AMINOBUTYRIC ACID N METHYLIMIDAZOLE BETA ALANINE N METHYLIMIDAZOLE N METHYLPYRROLE BETA ALANINE[((DIMETHYLAMINO)PROPYL)AMIDE]; BETA ALANINE BETA ALANINE N METHYLIMIDAZOLE N METHYLPYRROLE N METHYLIMIDAZOLE N METHYLPYRROLE GAMMA AMINOBUTYRIC ACID N METHYLIMIDAZOLE N METHYLPYRROLE N METHYLIMIDAZOLE N METHYLPYRROLE BETA ALANINE[((DIMETHYLAMINO)PROPYL)AMIDE]; POLYAMIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BASE MISPAIRING; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL PARAMETERS; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; GC RICH SEQUENCE; SURFACE PLASMON RESONANCE; SYNTHESIS;

EUKARYOTA;

DNA BINDING SMALL MOLECULE; POLYAMIDE; PYRROLE-IMIDAZOLE POLYAMIDE; SEQUENCE SPECIFICITY;

BASE PAIR MISMATCH; BASE SEQUENCE; BETA-ALANINE; DNA; IMIDAZOLES; NUCLEIC ACID CONFORMATION; NYLONS; PYRROLES; SURFACE PLASMON RESONANCE;

EID: 84881377219     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.005     Document Type: Article

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