Propofol stimulates noradrenalin-inhibited neurons in the ventrolateral preoptic nucleus by reducing GABAergic inhibition

Anesthesia and Analgesia

Volumn 117, Issue 2, 2013, Pages 358-363

  Liu, Yu Wei ^a   Zuo, Wanhong ^a   Ye, Jiang Hong ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NORADRENALIN; PROPOFOL;

ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; CELL STIMULATION; DRUG MECHANISM; ELECTROPHYSIOLOGY; GABAERGIC TRANSMISSION; HYPOTHALAMUS; MAMMILLARY BODY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; THALAMUS VENTRAL NUCLEUS;

ADRENERGIC NEURONS; ANESTHETICS, INTRAVENOUS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GABAERGIC NEURONS; GAMMA-AMINOBUTYRIC ACID; HYPNOTICS AND SEDATIVES; INHIBITORY POSTSYNAPTIC POTENTIALS; NEURAL INHIBITION; NOREPINEPHRINE; PREOPTIC AREA; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84881377108     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e318297366e     Document Type: Article

References (17)

1. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci 2002;5:979-84
2. Liu YW, Li J, Ye JH. Histamine regulates activation of neurons in the ventrolateral preoptic nucleus. Th J Physiology 2010;588:4103-16
3. Gallopin T, Fort P, Eggermann E, Cauli B, Luppi PH, Rossier J, Audinat E, Mühlethaler M, Serafn M. Identifcation of sleep-promoting neurons in vitro. Nature 2000;404:992-5
4. Liu YW, Li J, Ye JH. Histamine regulates activities of neurons in the ventrolateral preoptic nucleus. J Physiol 2010;588:4103-16
5. Trapani G, Altomare C, Liso G, Sanna E, Biggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem 2000;7:249-71
6. Bieda MC, MacIver MB. Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability. J Neurophysiol 2004;92:1658-67
7. Kotani Y, Shimazawa M, Yoshimura S, Iwama T, Hara H. The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties. CNS Neurosci Ther 2008;14:95-106
8. Lingamaneni R, Birch ML, Hemmings HC Jr. Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isofurane and propofol. Anesthesiology 2001;95:1460-6
9. Li KY, Guan YZ, Krnjevic K, Ye JH. Propofol facilitates gluta-matergic transmission to neurons of the ventrolateral preoptic nucleus. Anesthesiology 2009;111:1271-8
10. Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 2008;9:370-86
11. Gallopin T, Luppi PH, Rambert FA, Frydman A, Fort P. Effect of the wake-promoting agent modafnil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro phar-macologic study. Sleep 2004;27:19-25
12. Haas H, Panula P. The role of histamine and the tuber-omamillary nucleus in the nervous system. Nat Rev Neurosci 2003;4:121-30
13. Gredell JA, Turnquist PA, Maciver MB, Pearce RA. Determination of diffusion and partition coeffcients of propo-fol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth 2004;93:810-7
14. Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL. Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isofurane. Mol Pharmacol 1998;53:530-8
15. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J 2003;17:250-2
16. Alkire MT, Haier RJ. Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isofurane. Br J Anaesth 2001;86:618-26
17. Peretz A, Sheinin A, Yue C, Degani-Katzav N, Gibor G, Nachman R, Gopin A, Tam E, Shabat D, Yaari Y, Attali B. Pre-and postsynaptic activation of M-channels by a novel opener dampens neuronal fring and transmitter release. J Neurophysiol 2007;97:283-95