Association between steroid dosage and death with a functioning graft after kidney transplantation

American Journal of Transplantation

Volumn 13, Issue 8, 2013, Pages 2096-2105

  Opelz, G ^a   Dohler B ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Death with function; kidney transplant; steroids

Indexed keywords

AZATHIOPRINE; CREATININE; CYCLOSPORIN A; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PREDNISOLONE; PREDNISONE; STEROID; TACROLIMUS;

ADULT; ARTICLE; CANCER MORTALITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CREATININE BLOOD LEVEL; DISEASES; DRUG FATALITY; DRUG MEGADOSE; DRUG WITHDRAWAL; FEMALE; FUNCTIONAL STATUS; GRAFT FAILURE; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; KIDNEY DONOR; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; LONG TERM CARE; LOW DRUG DOSE; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; STEROID THERAPY;

DEATH WITH FUNCTION; KIDNEY TRANSPLANT; STEROIDS;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; CARDIOVASCULAR DISEASES; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFECTION; INTERNATIONAL AGENCIES; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PREDNISONE; RETROSPECTIVE STUDIES; SURVIVAL RATE; YOUNG ADULT;

EID: 84881374269     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12313     Document Type: Article

References (25)

1. Collins AJ, Foley RN, Herzog C, et al. US Renal Data System 2010 Annual Data Report. Am J Kidney Dis 2011; 57 (1 Suppl 1): A8, e1-526.
2. OPTN & SRTR Annual Data Report. 2010; Available at: http://srtr.transplant.hrsa.gov/annual-reports/2010/flash/00-full/index.html#/1/ . Accessed December 3, 2012.
3. Opelz G, Döhler B., Association of HLA mismatch with death with a functioning graft after kidney transplantation: A Collaborative Transplant Study Report. Am J Transplant 2012; 12: 3031-3038.
4. ANZDATA. www.anzdata.org.au. Accessed November 13, 2012.
5. Kahwaji J, Bunnapradist S, Hsu JW, Idroos ML, Dudek R., Cause of death with graft function among renal transplant recipients in an integrated healthcare system. Transplantation 2011; 91: 225-230.
6. Boots JM, Christiaans MH, van Hooff JP., Effect of immunosuppressive agents on long-term survival of renal transplant recipients: Focus on the cardiovascular risk. Drugs 2004; 64: 2047-2073.
7. Poetker DM, Reh DD., A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin NY Am 2010; 43: 753-768.
8. Knight SR, Morris PJ., Steroid avoidance or withdrawal after renal transplantation increases the risk of acute rejection but decreases cardiovascular risk. A meta-analysis. Transplantation 2010; 89: 1-14.
9. Vincenti F, Schena FP, Paraskevas S, et al. A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients. Am J Transplant 2008; 8: 307-316.
10. Vanrenterghem Y, Lebranchu Y, Hené R, Oppenheimer F, Ekberg H., Double-blind comparison of two corticosteroid regimens plus mycophenolate mofetil and cyclosporine for prevention of acute renal allograft rejection. Transplantation 2000; 70: 1352-1359.
11. Woodle ES, Peddi VR, Tomlanovich S, Mulgaonkar S, Kuo PC, TRIMS Study Investigators. A prospective, randomized, multicenter study evaluating early corticosteroid withdrawal with Thymoglobulin in living-donor kidney transplantation. Clin Transplant 2010; 24: 73-83.
12. Woodle ES, First MR, Pirsch J, et al. A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corticosteroid cessation versus long-term, low-dose corticosteroid therapy. Ann Surg 2008; 248: 564-577.
13. Nematalla AH, Bakr MA, Gheith OA, Elagroudy AE, Elshahawy el-M, Aghoneim M., Steroid-avoidance immunosuppression regimen in live-donor renal allotransplant recipients: A prospective, randomized, controlled study. Exp Clin Transplant 2007; 5: 673-679.
14. Knight SR, Morris PJ., Interaction between maintenance steroid dose and the risk/benefit of steroid avoidance and withdrawal regimens following renal transplantation. Transplantation 2011; 92: e63-e64.
15. Pascual J, Zamora J, Galeano C, Royuela A, Quereda C., Steroid avoidance or withdrawal for kidney transplant recipients. Cochrane Database Syst Rev 2009 (1): CD005632.
16. Cantarovich D, Rostaing L, Kamar N., et al. Corticosteroid avoidance in adult kidney transplant recipients under rabbit anti-T-lymphocyte globulin, mycophenolate mofetil and delayed cyclosporine microemulsion introduction. Transpl Int 2010; 23: 313-324.
17. Vincenti F, Monaco A, Grinyo J, Kinkhabwala M, Roza A., Multicenter randomized prospective trial of steroid withdrawal in renal transplant recipients receiving basiliximab, cyclosporine microemulsion and mycophenolate mofetil. Am J Transplant 2003; 3: 306-311.
18. ter Meulen CG, van Riemsdijk I, Hené RJ, et al. Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: A prospective, randomized, multicenter study. Am J Transplant 2004; 4: 803-810.
19. Ahsan N, Hricik D, Matas A., et al. Prednisone withdrawal in kidney transplant recipients on cyclosporine and mycophenolate mofetil-A prospective randomized study. Transplantation 1999; 68: 1865-1874.
20. Pascual J, Royuela A, Galeano C, Crespo M, Zamora J., Very early steroid withdrawal or complete avoidance for kidney transplant recipients: A systematic review. Nephrol Dial Transplant 2012; 27: 825-832.
21. Opelz G, Döhler B, Laux G, for the Collaborative Transplant Study. Long-term prospective study of steroid withdrawal in kidney and heart transplant recipients. Am J Transplant 2005; 5: 720-728.
22. Haynes RC, Murad F., Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In:, Goodman LS, Gilman A, Rall TW, Nies AS, Taylor P, eds. Goodman and Gilman's, The Pharmacological Basis of Therapeutics. 8th ed. New York: Macmillan Publishing Company, 1991; p. 1431.
23. Arns W, Breuer S, Choudhury S, et al. Enteric-coated mycophenolate sodium delivers bioequivalent MPA exposure compared with mycophenolate mofetil. Clin Transplant 2005; 19: 199-206.
24. Opelz G, Wujciak T, Ritz E, for the Collaborative Transplant Study. Association of chronic kidney graft failure with recipient blood pressure. Kidney Int 1998; 53: 217-222.
25. Weiner DE, Carpenter MA, Levey AS, et al. Kidney function and risk of cardiovascular disease and mortality in kidney transplant recipients: The FAVORIT trial. Am J Transplant 2012; 12: 2437-2445.