Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution

International Journal for Numerical Methods in Biomedical Engineering

Volumn 29, Issue 8, 2013, Pages 870-884

  Miller, Renee ^a   Davies, Neil H ^a   Kortsmit, Jeroen ^a   Zilla, Peter ^a   Franz, Thomas ^a,b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b CENTRE FOR HIGH PERFORMANCE COMPUTING   (South Africa)

Author keywords

Adverse remodelling; Finite element analysis; Heart failure; Intra myocardial injectate; Myocardial infarction; Myocardial stress

Indexed keywords

ADVERSE REMODELLING; EJECTION FRACTION; END-DIASTOLIC; HEART FAILURE; INTRA-MYOCARDIAL INJECTATE; LEFT VENTRICLES; MYOCARDIAL INFARCTION; STRESS AND STRAIN;

BIOLOGICAL MATERIALS; CARDIOLOGY; FINITE ELEMENT METHOD; MAGNETIC RESONANCE IMAGING;

HYDROGELS;

ADVERSE REMODELLING; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HEART; HEART FAILURE; HEART INFARCTION; HEART MUSCLE; HEART VENTRICLE; HEART VENTRICLE REMODELING; HEMODYNAMICS; HUMAN; HYDROGEL; INJECTION; INTRA-MYOCARDIAL INJECTATE; METABOLISM; MYOCARDIAL STRESS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; THREE DIMENSIONAL IMAGING;

ADVERSE REMODELLING; FINITE ELEMENT ANALYSIS; HEART FAILURE; INTRA-MYOCARDIAL INJECTATE; MYOCARDIAL INFARCTION; MYOCARDIAL STRESS;

COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HEART; HEART VENTRICLES; HEMODYNAMICS; HUMANS; HYDROGEL; IMAGING, THREE-DIMENSIONAL; INJECTIONS; MAGNETIC RESONANCE IMAGING, CINE; MODELS, CARDIOVASCULAR; MYOCARDIAL INFARCTION; MYOCARDIUM; VENTRICULAR REMODELING;

EID: 84881371183     PISSN: 20407939     EISSN: 20407947     Source Type: Journal    
DOI: 10.1002/cnm.2551     Document Type: Article

References (44)

1. WHO. The Atlas of Heart Disease and Stroke. World Health Organization: Geneva, 2008.
2. AHA. Heart Disease and Stroke Statistics: Our Guide to Current Statistics and the Supplement to our Heart and Stroke Facts, American Heart Association: Dallas, 2008.
3. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: Pathophysiology and therapy. Circulation 2000; 101: 2981-2988.
4. Holmes JW, Borg TK, Covell JW. Structure and mechanics of healing myocardial infarcts. Annual Review of Biomedical Engineering 2005; 7: 223-253.
5. Opie LH, Commerford PJ, Gersh BJ, Pfeffer MA. Controversies in ventricular remodelling. Lancet 2006; 367: 356-367.
6. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990; 81: 1161-1172.
7. Kofidis T, Lebl DR, Martinez EC, Hoyt G, Tanaka M, Robbins RC. Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury. Circulation 2005; 112: I173-I177.
8. Christman KL, Fok HH, Sievers RE, Fang Q, Lee RJ. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Engineering 2004; 10: 403-409.
9. Christman KL, Vardanian AJ, Fang Q, Sievers RE, Fok HH, Lee RJ. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. Journal of the American College Of Cardiology 2004; 44: 654-660.
10. Tomita S, Mickle DA, Weisel RD, Jia ZQ, Tumiati LC, Allidina Y, Liu P, Li RK. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. Journal Of Thoracic and Cardiovascular Surgery 2002; 123: 1132-1140.
11. Dobner S, Bezuidenhout D, Govender P, Zilla P, Davies N. A synthetic non-degradable polyethylene glycol hydrogel retards adverse post-infarct left ventricular remodeling. Journal of Cardiac Failure 2009; 15: 629-636.
12. Nelson DM, Ma Z, Fujimoto KL, Hashizume R, Wagner WR. Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges. Acta Biomaterialia 2011; 7: 1-15.
13. Kerckhoffs RCP, McCulloch AD, Omens JH, Mulligan LJ. Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block. Medical Image Analysis 2009; 13: 362-369.
14. Usyk TP, McCulloch AD. Electromechanical model of cardiac resynchronization in the dilated failing heart with left bundle branch block. Journal of Electrocardiology 2003; 36: 57-61.
15. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. Journal of Thoracic and Cardiovascular Surgery 2008; 135: 1094-1102.
16. Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB. Myosplint decreases wall stress without depressing function in the failing heart: A finite element model study. Annals of Thoracic Surgery 2003; 76: 1171-1180.
17. Vetter FJ, McCulloch AD. Three-dimensional stress and strain in passive rabbit left ventricle: A model study. Annals of Biomedical Engineering 2000; 28: 781-792.
18. Smith NP, Mulquiney PJ, Nash MP, Bradley CP, Nickerson DP, Hunter PJ. Mathematical modelling of the heart: Cell to organ. Chaos, Solitons & Fractals 2002; 13: 1613-1621.
19. Nordsletten D, McCormick M, Kilner PJ, Hunter P, Kay D, Smith NP. Fluid-solid coupling for the investigation of diastolic and systolic human left ventricular function. International Journal for Numerical Methods in Biomedical Engineering 2011; 27: 1017-1039.
20. Niederer SA, Smith NP. At the heart of computational modelling. Journal of Physiology 2012; 590: 1331-1338.
21. Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM. Theoretical impact of the injection of material into the myocardium - a finite element model simulation. Circulation 2006; 114: 2627-2635.
22. Wenk JF, Wall ST, Peterson RC, Helgerson SL, Sabbah HN, Burger M, Stander N, Ratcliffe MB, Guccione JM. A method for automatically optimizing medical devices for treating heart failure: Designing polymeric injection patterns. Journal of Biomechanical Engineering 2009; 131: 121011-1-121011-7.
23. Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman Iii JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction. Annals of Thoracic Surgery 2011; 92: 935-941.
24. Ifkovits JL, Tous E, Minakawa M, Morita M, Robb JD, Koomalsingh KJ, Gorman JH, Gorman RC, Burdick JA. Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model. Proceedings of the National Academy of Sciences 2010; 107: 11507-11512.
25. Kadner K, Dobner S, Franz T, Bezuidenhout D, Sirry MS, Zilla P, Davies NH. The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction. Biomaterials 2012; 33: 2060-2066.
26. Kortsmit J, Davies NH, Miller R, Macadangdang JR, Zilla P, Franz T. The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model. Computer Methods in Biomechanics and Biomedical Engineering 2012; epub, DOI: 10.1080/10255842.2012.656611.
27. Heiberg E, Sjogren J, Ugander M, Carlsson M, Engblom H, Arheden H. Design and validation of Segment - freely available software for cardiovascular image analysis. BMC Medical Imaging 2010; 10: 1-13.
28. Heiberg E, Engblom H, Engvall J, Hedström E, Ugander M, Arheden H. Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging. Scandinavian Cardiovascular Journal 2005; 39: 267-275.
29. Rohmer D, Sitek A, Gullberg GT. Reconstruction and visualization of fiber and laminar structure in the normal human heart from ex vivo diffusion tensor magnetic resonance imaging (dtmri) data. Investigative Radiology 2007; 42: 777-789.
30. Guccione JM, Costa KD, McCulloch AD. Finite element stress analysis of left ventricular mechanics in the beating dog heart. Journal of Biomechanics 1995; 28: 1167-1177.
31. Liu C, Hofstetter G, Mang H. 3d finite element analysis of rubber-like materials at finite strains. Engineering Computations 1994; 11: 111-128.
32. Doll S, Schweizerhof K. On the development of volumetric strain energy functions. Journal of Applied Mechanics 2000; 67: 17-21.
33. Guccione JM, Waldman LK, Mcculloch AD. Mechanics of active contraction in cardiac-muscle. Part 2: Cylindrical models of the systolic left-ventricle. Journal of Biomechanical Engineering 1993; 115: 82-90.
34. Ter Keurs H. Calcium and contractility. In Cardiac Metabolism, Drake-Holland AJ (ed.). Wiley: New York, 1983; 73-99.
35. Ter Keurs H, Rijnsburger W, Van Heuningen R, Nagelsmit M. Tension development sarcomere length in rat cardiac trabeculae. Evidence of length-dependent activation. Circulation Research 1980; 46: 703-714.
36. Sun K, Stander N, Jhun C, Zhang Z, Suzuki T, Wang G, Saeed M, Wallace A, Tseng E, Baker A. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. Journal of Biomechanical Engineering 2009; 131: 111001-1-111001-10.
37. Omens J, May K, McCulloch A. Transmural distribution of three-dimensional strain in the isolated arrested canine left ventricle. American Journal of Physiology- Heart and Circulatory Physiology 1991; 261: H918-H928.
38. Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman Iii JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction. The Annals of Thoracic Surgery 2011; 92: 935-941.
39. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. American Journal of Physiology-Heart and Circulatory Physiology 2005; 289: H692-H700.
40. Kortsmit J, Davies NH, Miller R, Zilla P, Franz T. Computational predictions of improved wall mechanics and function of the infarcted left ventricle at early and late remodeling stages: Comparison of layered and bulk hydrogel injectates. Advances in Biomechanics and Applications 2013; in review.
41. Schlosser T, Pagonidis K, Herborn CU, Hunold P, Waltering K-U, Lauenstein TC, Barkhausen J. Assessment of left ventricular parameters using 16-mdct and new software for endocardial and epicardial border delineation. American Journal of Roentgenology 2005; 184: 765-773.
42. Guccione JM, McCulloch AD. Mechanics of active contraction in cardiac muscle. Part 1: Constitutive relations for fiber stress that describe deactivation. Journal of Biomedical Engineering 1993; 115: 72-81.
43. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. American Journal of Physiology - Heart and Circulatory Physiology 2005; 289: H692-H700.
44. Sermesant M, Razavi R. Personalized computational models of the heart for cardiac resynchronization therapy. In Patient-specific Modeling of the Cardiovascular System, Kerckhoffs RCP (ed.). Springer: New York, 2010: 765-773.