메뉴 건너뛰기




Volumn 13, Issue 8, 2013, Pages 2169-2178

Ex vivo-expanded cynomolgus macaque regulatory T cells are resistant to Alemtuzumab-mediated cytotoxicity

Author keywords

Alemtuzumab; Campath 1H; nonhuman primate; regulatory T cells; transplantation

Indexed keywords

ALEMTUZUMAB; CD52 ANTIGEN; MEMBRANE COFACTOR PROTEIN;

EID: 84881371102     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12248     Document Type: Article
Times cited : (11)

References (25)
  • 2
    • 0024204319 scopus 로고
    • Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H
    • Hale G, Dyer MJ, Clark MR, et al. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet 1988; 2: 1394-1399.
    • (1988) Lancet , vol.2 , pp. 1394-1399
    • Hale, G.1    Dyer, M.J.2    Clark, M.R.3
  • 3
    • 20144389244 scopus 로고    scopus 로고
    • Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with thymoglobulin or Campath
    • Shapiro R, Basu A, Tan H, et al. Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with thymoglobulin or Campath. J Am Coll Surg 2005; 200: 505-515.
    • (2005) J Am Coll Surg , vol.200 , pp. 505-515
    • Shapiro, R.1    Basu, A.2    Tan, H.3
  • 4
    • 69949120991 scopus 로고    scopus 로고
    • Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model
    • Hu Y, Turner MJ, Shields J, et al. Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model. Immunology 2009; 128: 260-270.
    • (2009) Immunology , vol.128 , pp. 260-270
    • Hu, Y.1    Turner, M.J.2    Shields, J.3
  • 5
    • 33749445918 scopus 로고    scopus 로고
    • Different mechanisms of Campath-1H-mediated depletion for CD4 and CD8 T cells in peripheral blood
    • Lowenstein H, Shah A, Chant A, Khan A., Different mechanisms of Campath-1H-mediated depletion for CD4 and CD8 T cells in peripheral blood. Transpl Int 2006; 19: 927-936.
    • (2006) Transpl Int , vol.19 , pp. 927-936
    • Lowenstein, H.1    Shah, A.2    Chant, A.3    Khan, A.4
  • 6
    • 0038578245 scopus 로고    scopus 로고
    • Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: Relevance for early adoptive immunotherapy and infectious complications
    • Morris EC, Rebello P, Thomson KJ, et al. Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: Relevance for early adoptive immunotherapy and infectious complications. Blood 2003; 102: 404-406.
    • (2003) Blood , vol.102 , pp. 404-406
    • Morris, E.C.1    Rebello, P.2    Thomson, K.J.3
  • 7
    • 0037364976 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation tolerance
    • Wood KJ, Sakaguchi S., Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199-210.
    • (2003) Nat Rev Immunol , vol.3 , pp. 199-210
    • Wood, K.J.1    Sakaguchi, S.2
  • 8
    • 17144374934 scopus 로고    scopus 로고
    • Regulatory T-cell therapy: Is it ready for the clinic
    • Bluestone JA., Regulatory T-cell therapy: Is it ready for the clinic ? Nat Rev Immunol 2005; 5: 343-349.
    • (2005) Nat Rev Immunol , vol.5 , pp. 343-349
    • Bluestone, J.A.1
  • 10
    • 0037570860 scopus 로고    scopus 로고
    • Regulatory T cells in the control of transplantation tolerance and autoimmunity
    • Jiang S, Lechler RI., Regulatory T cells in the control of transplantation tolerance and autoimmunity. Am J Transplant 2003; 3: 516-524.
    • (2003) Am J Transplant , vol.3 , pp. 516-524
    • Jiang, S.1    Lechler, R.I.2
  • 11
    • 84861568296 scopus 로고    scopus 로고
    • Regulatory immune cells in transplantation
    • Wood KJ, Bushell A, Hester J., Regulatory immune cells in transplantation. Nat Rev Immunol 2012; 12: 417-430.
    • (2012) Nat Rev Immunol , vol.12 , pp. 417-430
    • Wood, K.J.1    Bushell, A.2    Hester, J.3
  • 12
    • 76249084928 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
    • Raimondi G, Sumpter TL, Matta BM, et al. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol 2010; 184: 624-636.
    • (2010) J Immunol , vol.184 , pp. 624-636
    • Raimondi, G.1    Sumpter, T.L.2    Matta, B.M.3
  • 13
    • 40449101381 scopus 로고    scopus 로고
    • CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H
    • Bloom DD, Chang Z, Fechner JH, et al. CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am J Transplant 2008; 8: 793-802.
    • (2008) Am J Transplant , vol.8 , pp. 793-802
    • Bloom, D.D.1    Chang, Z.2    Fechner, J.H.3
  • 14
    • 47249132479 scopus 로고    scopus 로고
    • Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: Clinical outcomes and effect on T-regulatory cells
    • Pascual J, Bloom D, Torrealba J, et al. Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: Clinical outcomes and effect on T-regulatory cells. Am J Transplant 2008; 8: 1529-1536.
    • (2008) Am J Transplant , vol.8 , pp. 1529-1536
    • Pascual, J.1    Bloom, D.2    Torrealba, J.3
  • 15
    • 84859638759 scopus 로고    scopus 로고
    • Long-term effects of alemtuzumab on regulatory and memory T-cell subsets in kidney transplantation
    • Macedo C, Walters JT, Orkis EA, et al. Long-term effects of alemtuzumab on regulatory and memory T-cell subsets in kidney transplantation. Transplantation 2012; 93: 813-821.
    • (2012) Transplantation , vol.93 , pp. 813-821
    • MacEdo, C.1    Walters, J.T.2    Orkis, E.A.3
  • 16
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics. Blood 2011; 117: 1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 17
    • 33749259809 scopus 로고    scopus 로고
    • A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells
    • Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N., A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol 2006; 17: 2844-2853.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2844-2853
    • Lopez, M.1    Clarkson, M.R.2    Albin, M.3    Sayegh, M.H.4    Najafian, N.5
  • 18
    • 77949846514 scopus 로고    scopus 로고
    • Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys
    • van der Windt DJ, Smetanka C, Macedo C, et al. Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys. Am J Transplant 2010; 10: 773-783.
    • (2010) Am J Transplant , vol.10 , pp. 773-783
    • Van Der Windt, D.J.1    Smetanka, C.2    MacEdo, C.3
  • 19
    • 0026487081 scopus 로고
    • Identification of an abundant monkey epididymal transcript encoding a homologue of human CAMPATH-1 antigen precursor
    • Perry AC, Jones R, Hall L., Identification of an abundant monkey epididymal transcript encoding a homologue of human CAMPATH-1 antigen precursor. Biochim Biophys Acta 1992; 1171: 122-124.
    • (1992) Biochim Biophys Acta , vol.1171 , pp. 122-124
    • Perry, A.C.1    Jones, R.2    Hall, L.3
  • 20
    • 1842369667 scopus 로고    scopus 로고
    • Interaction of the human epididymal protein CD52 (HE5) with epididymal spermatozoa from men and cynomolgus monkeys
    • Yeung CH, Schroter S, Wagenfeld A, et al. Interaction of the human epididymal protein CD52 (HE5) with epididymal spermatozoa from men and cynomolgus monkeys. Mol Reprod Dev 1997; 48: 267-275.
    • (1997) Mol Reprod Dev , vol.48 , pp. 267-275
    • Yeung, C.H.1    Schroter, S.2    Wagenfeld, A.3
  • 21
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 22
    • 84859102273 scopus 로고    scopus 로고
    • Induced regulatory T cells: Mechanisms of conversion and suppressive potential
    • Dons EM, Raimondi G, Cooper DK, Thomson AW., Induced regulatory T cells: Mechanisms of conversion and suppressive potential. Hum Immunol 2012; 73: 328-334.
    • (2012) Hum Immunol , vol.73 , pp. 328-334
    • Dons, E.M.1    Raimondi, G.2    Cooper, D.K.3    Thomson, A.W.4
  • 23
    • 84856317305 scopus 로고    scopus 로고
    • Favorable effects of alemtuzumab on allospecific regulatory T-cell generation
    • Levitsky J, Leventhal JR, Miller J, et al. Favorable effects of alemtuzumab on allospecific regulatory T-cell generation. Hum Immunol 2012; 73: 141-149.
    • (2012) Hum Immunol , vol.73 , pp. 141-149
    • Levitsky, J.1    Leventhal, J.R.2    Miller, J.3
  • 24
    • 8544281696 scopus 로고    scopus 로고
    • Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals
    • Zou L, Barnett B, Safah H, et al. Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res 2004; 64: 8451-8455.
    • (2004) Cancer Res , vol.64 , pp. 8451-8455
    • Zou, L.1    Barnett, B.2    Safah, H.3
  • 25
    • 77953032292 scopus 로고    scopus 로고
    • Effect of anti-CD52 antibody alemtuzumab on ex-vivo culture of umbilical cord blood stem cells
    • Lim CK, Sun L, Feng Q, et al. Effect of anti-CD52 antibody alemtuzumab on ex-vivo culture of umbilical cord blood stem cells. J Hematol Oncol 2008; 1: 19.
    • (2008) J Hematol Oncol , vol.1 , pp. 19
    • Lim, C.K.1    Sun, L.2    Feng, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.