Permeability diagnosis model in drug discovery: A diagnostic tool to identify the most influencing properties for gastrointestinal permeability

Current Topics in Medicinal Chemistry

Volumn 13, Issue 11, 2013, Pages 1308-1316

  Wang, Jianling ^a   Skolnik, Suzanne ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

ADME; Caco 2 and PAMPA; Gastrointestinal permeability; Oral absorption; Permeability diagnosis; Transporter

Indexed keywords

AZTREONAM; FENOTEROL; LISINOPRIL; NAVELBINE; SALAZOSULFAPYRIDINE; SAQUINAVIR;

ARTICLE; DRUG ABSORPTION; DRUG PENETRATION; HUMAN; INTESTINE MUCOSA PERMEABILITY; IONIZATION; LIPOPHILICITY; MEMBRANE PERMEABILITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS;

BIOLOGICAL ASSAY; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GASTROINTESTINAL TRACT; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANES, ARTIFICIAL; PHARMACEUTICAL PREPARATIONS; PRINCIPAL COMPONENT ANALYSIS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881354361     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/15680266113139990035     Document Type: Article

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