메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Prognostic Significance of ESR1 Amplification and ESR1 PvuII, CYP2C19*2, UGT2B15*2 Polymorphisms in Breast Cancer Patients

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C19; ESTROGEN RECEPTOR ALPHA; GENOMIC DNA; TAMOXIFEN;

EID: 84881328405     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072219     Document Type: Article
Times cited : (23)

References (37)
  • 1
    • 0031240327 scopus 로고    scopus 로고
    • Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice
    • doi: 10.1023/A:1026339111278
    • Bocchinfuso WP, Korach KS, (1997) Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice. J Mammary Gland Biol Neoplasia 2: 323-334. doi:10.1023/A:1026339111278. PubMed: 10935020.
    • (1997) J Mammary Gland Biol Neoplasia , vol.2 , pp. 323-334
    • Bocchinfuso, W.P.1    Korach, K.S.2
  • 2
    • 0034671471 scopus 로고    scopus 로고
    • Estrogen promotes mammary tumor development in C3(1)/SV40 large T-antigen transgenic mice: paradoxical loss of estrogen receptoralpha expression during tumor progression
    • 11156389
    • Yoshidome K, Shibata MA, Couldrey C, Korach KS, Green JE, (2000) Estrogen promotes mammary tumor development in C3(1)/SV40 large T-antigen transgenic mice: paradoxical loss of estrogen receptoralpha expression during tumor progression. Cancer Res 60: 6901-6910. PubMed: 11156389.
    • (2000) Cancer Res , vol.60 , pp. 6901-6910
    • Yoshidome, K.1    Shibata, M.A.2    Couldrey, C.3    Korach, K.S.4    Green, J.E.5
  • 3
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • EBCTCG,doi: 10.1016/S0140-6736(05)66544-0
    • EBCTCG (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365: 1687-1717. doi:10.1016/S0140-6736(05)66544-0. PubMed: 15894097.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 4
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • doi: 10.1038/nrc2713
    • Musgrove EA, Sutherland RL, (2009) Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 9: 631-643. doi:10.1038/nrc2713. PubMed: 19701242.
    • (2009) Nat Rev Cancer , vol.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 5
    • 46249103138 scopus 로고    scopus 로고
    • ESR1 gene amplification in breast cancer: a common phenomenon?
    • author reply 810-802,doi: 10.1038/ng0708-809b
    • Vincent-Salomon A, Raynal V, Lucchesi C, Gruel N, Delattre O, (2008) ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet 40: 809; author reply 810-802 doi:10.1038/ng0708-809b. PubMed: 1858396718583966.
    • (2008) Nat Genet , vol.40 , pp. 809
    • Vincent-Salomon, A.1    Raynal, V.2    Lucchesi, C.3    Gruel, N.4    Delattre, O.5
  • 6
    • 67649870743 scopus 로고    scopus 로고
    • Estrogen receptor alpha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients
    • doi: 10.1111/j.1349-7006.2009.01145.x
    • Tomita S, Zhang Z, Nakano M, Ibusuki M, Kawazoe T, et al. (2009) Estrogen receptor alpha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients. Cancer Sci 100: 1012-1017. doi:10.1111/j.1349-7006.2009.01145.x. PubMed: 19320640.
    • (2009) Cancer Sci , vol.100 , pp. 1012-1017
    • Tomita, S.1    Zhang, Z.2    Nakano, M.3    Ibusuki, M.4    Kawazoe, T.5
  • 7
    • 34247634643 scopus 로고    scopus 로고
    • Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
    • doi: 10.1038/ng2006
    • Holst F, Stahl PR, Ruiz C, Hellwinkel O, Jehan Z, et al. (2007) Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet 39: 655-660. doi:10.1038/ng2006. PubMed: 17417639.
    • (2007) Nat Genet , vol.39 , pp. 655-660
    • Holst, F.1    Stahl, P.R.2    Ruiz, C.3    Hellwinkel, O.4    Jehan, Z.5
  • 8
    • 79958182017 scopus 로고    scopus 로고
    • Amplification of ESR1 may predict resistance to adjuvant tamoxifen in postmenopausal patients with hormone receptor positive breast cancer
    • doi: 10.1007/s10549-010-0984-y
    • Nielsen KV, Ejlertsen B, Müller S, Møller S, Rasmussen BB, et al. (2011) Amplification of ESR1 may predict resistance to adjuvant tamoxifen in postmenopausal patients with hormone receptor positive breast cancer. Breast Cancer Res Treat 127: 345-355. doi:10.1007/s10549-010-0984-y. PubMed: 20556506.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 345-355
    • Nielsen, K.V.1    Ejlertsen, B.2    Müller, S.3    Møller, S.4    Rasmussen, B.B.5
  • 9
    • 84860462662 scopus 로고    scopus 로고
    • Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial
    • doi: 10.1093/annonc/mdr438
    • Ejlertsen B, Aldridge J, Nielsen KV, Regan MM, Henriksen KL, et al. (2012) Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial. Annals Oncology Off J Eur Soc Medical Oncology/ESMO 23: 1138-1144. doi:10.1093/annonc/mdr438. PubMed: 21986093.
    • (2012) Annals Oncology Off J Eur Soc Medical Oncology/ESMO , vol.23 , pp. 1138-1144
    • Ejlertsen, B.1    Aldridge, J.2    Nielsen, K.V.3    Regan, M.M.4    Henriksen, K.L.5
  • 11
    • 0024490659 scopus 로고
    • Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism
    • 2562795
    • Hill SM, Fuqua SA, Chamness GC, Greene GL, McGuire WL, (1989) Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism. Cancer Res 49: 145-148. PubMed: 2562795.
    • (1989) Cancer Res , vol.49 , pp. 145-148
    • Hill, S.M.1    Fuqua, S.A.2    Chamness, G.C.3    Greene, G.L.4    McGuire, W.L.5
  • 12
    • 0036325773 scopus 로고    scopus 로고
    • Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen
    • doi: 10.1124/dmd.30.8.869
    • Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM, (2002) Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos Biol Fate Chem 30: 869-874. doi:10.1124/dmd.30.8.869. PubMed: 12124303.
    • (2002) Drug Metab Dispos Biol Fate Chem , vol.30 , pp. 869-874
    • Crewe, H.K.1    Notley, L.M.2    Wunsch, R.M.3    Lennard, M.S.4    Gillam, E.M.5
  • 13
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • doi: 10.2165/00003088-200241120-00002
    • Desta Z, Zhao X, Shin JG, Flockhart DA, (2002) Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 41: 913-958. doi:10.2165/00003088-200241120-00002. PubMed: 12222994.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.G.3    Flockhart, D.A.4
  • 14
    • 0037094334 scopus 로고    scopus 로고
    • Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases
    • doi: 10.1016/S0006-2952(02)00994-2
    • Nishiyama T, Ogura K, Nakano H, Ohnuma T, Kaku T, et al. (2002) Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases. Biochem Pharmacol 63: 1817-1830. doi:10.1016/S0006-2952(02)00994-2. PubMed: 12034366.
    • (2002) Biochem Pharmacol , vol.63 , pp. 1817-1830
    • Nishiyama, T.1    Ogura, K.2    Nakano, H.3    Ohnuma, T.4    Kaku, T.5
  • 15
    • 0030795936 scopus 로고    scopus 로고
    • Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene
    • doi: 10.1097/00008571-199708000-00007
    • Lévesque E, Beaulieu M, Green MD, Tephly TR, Bélanger A, et al. (1997) Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 7: 317-325. doi:10.1097/00008571-199708000-00007. PubMed: 9295060.
    • (1997) Pharmacogenetics , vol.7 , pp. 317-325
    • Lévesque, E.1    Beaulieu, M.2    Green, M.D.3    Tephly, T.R.4    Bélanger, A.5
  • 16
    • 84881331452 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen in relation to disease-free survival in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial
    • Dezentje VO, Schaik RHV, Vletter-Bogaartz JM, Wessels JA, Hille ET, et al. (2010) Pharmacogenetics of tamoxifen in relation to disease-free survival in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial. 2010 ASCO, Annual Meeting.
    • (2010) 2010 ASCO, Annual Meeting
    • Dezentje, V.O.1    Schaik, R.H.V.2    Vletter-Bogaartz, J.M.3    Wessels, J.A.4    Hille, E.T.5
  • 17
    • 78149337096 scopus 로고    scopus 로고
    • CYP2C19*2 polymorphism is associated with increased survival in breast cancer patients using tamoxifen
    • doi: 10.2217/pgs.10.112
    • Ruiter R, Bijl MJ, van Schaik RH, Berns EM, Hofman A, et al. (2010) CYP2C19*2 polymorphism is associated with increased survival in breast cancer patients using tamoxifen. Pharmacogenomics 11: 1367-1375. doi:10.2217/pgs.10.112. PubMed: 21047200.
    • (2010) Pharmacogenomics , vol.11 , pp. 1367-1375
    • Ruiter, R.1    Bijl, M.J.2    van Schaik, R.H.3    Berns, E.M.4    Hofman, A.5
  • 18
    • 21344467511 scopus 로고    scopus 로고
    • Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    • doi: 10.1007/s10549-004-7751-x
    • Nowell SA, Ahn JY, Rae JM, Scheys JO, Trovato A, et al. (2005) Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91: 249-258. doi:10.1007/s10549-004-7751-x. PubMed: 15952058.
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 249-258
    • Nowell, S.A.1    Ahn, J.Y.2    Rae, J.M.3    Scheys, J.O.4    Trovato, A.5
  • 19
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
    • doi: 10.1093/annonc/mdr304
    • Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B, et al. (2011) Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 22: 1736-1747. doi:10.1093/annonc/mdr304. PubMed: 21709140.
    • (2011) Ann Oncol , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3    Gelber, R.D.4    Thürlimann, B.5
  • 20
    • 84881341608 scopus 로고    scopus 로고
    • Development and Evaluation of Clinical Significance of a Real-Time PCR Assay for TOP2A Copy Number Determination in Breast Cancer
    • Zaczek A, Markiewicz A, Jaskiewicz J, Pienkowski T, Rhone P, et al. (2010) Development and Evaluation of Clinical Significance of a Real-Time PCR Assay for TOP2A Copy Number Determination in Breast Cancer. Ann Oncol 21: 57-57.
    • (2010) Ann Oncol , vol.21 , pp. 57
    • Zaczek, A.1    Markiewicz, A.2    Jaskiewicz, J.3    Pienkowski, T.4    Rhone, P.5
  • 21
    • 45449087921 scopus 로고    scopus 로고
    • qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
    • 17291332
    • Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J, (2007) qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 8: R19-. PubMed: 17291332.
    • (2007) Genome Biol , vol.8
    • Hellemans, J.1    Mortier, G.2    De Paepe, A.3    Speleman, F.4    Vandesompele, J.5
  • 22
    • 0026552252 scopus 로고
    • Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood
    • 1345763
    • Yaich L, Dupont WD, Cavener DR, Parl FF, (1992) Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res 52: 77-83. PubMed: 1345763.
    • (1992) Cancer Res , vol.52 , pp. 77-83
    • Yaich, L.1    Dupont, W.D.2    Cavener, D.R.3    Parl, F.F.4
  • 23
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • 8195181
    • de Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, et al. (1994) The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 269: 15419-15422. PubMed: 8195181.
    • (1994) J Biol Chem , vol.269 , pp. 15419-15422
    • de Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3    Nakamura, K.4    Meyer, U.A.5
  • 24
    • 84881358339 scopus 로고    scopus 로고
    • Allele and genotype frequencies of cytochrome P450 2B6 and 2C19 genetic polymorphisms in the Nigerian populations: Possible implication on anti-retroviral and anti-malarial therapy
    • Ebeshi B, Bolaji O, Masimirembwa C, (2011) Allele and genotype frequencies of cytochrome P450 2B6 and 2C19 genetic polymorphisms in the Nigerian populations: Possible implication on anti-retroviral and anti-malarial therapy. Int J Med Medical Sciences 3: 193-200.
    • (2011) Int J Med Medical Sciences , vol.3 , pp. 193-200
    • Ebeshi, B.1    Bolaji, O.2    Masimirembwa, C.3
  • 25
    • 24944452378 scopus 로고    scopus 로고
    • REporting recommendations for tumour MARKer prognostic studies (REMARK)
    • doi: 10.1038/sj.bjc.6602678
    • McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, et al. (2005) REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer 93: 387-391. doi:10.1038/sj.bjc.6602678. PubMed: 16106245.
    • (2005) Br J Cancer , vol.93 , pp. 387-391
    • McShane, L.M.1    Altman, D.G.2    Sauerbrei, W.3    Taube, S.E.4    Gion, M.5
  • 26
    • 46249103138 scopus 로고    scopus 로고
    • ESR1 gene amplification in breast cancer: a common phenomenon?
    • author reply 810-802,doi: 10.1038/ng0708-809b
    • Reis-Filho JS, Drury S, Lambros MB, Marchio C, Johnson N, et al. (2008) ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet 40: 809-810; author reply 810-802 doi:10.1038/ng0708-809b. PubMed: 1858396718583966.
    • (2008) Nat Genet , vol.40 , pp. 809-810
    • Reis-Filho, J.S.1    Drury, S.2    Lambros, M.B.3    Marchio, C.4    Johnson, N.5
  • 27
    • 84859631946 scopus 로고    scopus 로고
    • Gene amplification of ESR1 in breast cancers--fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study
    • doi: 10.1002/path.4064
    • Ooi A, Inokuchi M, Harada S, Inazawa J, Tajiri R, et al. (2012) Gene amplification of ESR1 in breast cancers--fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study. J Pathol 227: 8-16. doi:10.1002/path.4064. PubMed: 22170254.
    • (2012) J Pathol , vol.227 , pp. 8-16
    • Ooi, A.1    Inokuchi, M.2    Harada, S.3    Inazawa, J.4    Tajiri, R.5
  • 28
    • 79952279120 scopus 로고    scopus 로고
    • ESR1 amplification is rare in breast cancer and is associated with high grade and high proliferation: a multiplex ligation-dependent probe amplification study
    • 215417332042168820966540
    • Moelans CB, Monsuur HN, de Pinth JH, Radersma RD, de Weger RA, et al. (2010) ESR1 amplification is rare in breast cancer and is associated with high grade and high proliferation: a multiplex ligation-dependent probe amplification study. Anal Cell Pathol 33: 13-18. PubMed: 215417332042168820966540.
    • (2010) Anal Cell Pathol , vol.33 , pp. 13-18
    • Moelans, C.B.1    Monsuur, H.N.2    de Pinth, J.H.3    Radersma, R.D.4    de Weger, R.A.5
  • 29
    • 46249092751 scopus 로고    scopus 로고
    • ESR1 gene amplification in breast cancer: a common phenomenon?
    • author reply 810-802,doi: 10.1038/ng0708-806
    • Brown LA, Hoog J, Chin SF, Tao Y, Zayed AA, et al. (2008) ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet 40: 806-807; author reply 810-802 doi:10.1038/ng0708-806. PubMed: 18583964.
    • (2008) Nat Genet , vol.40 , pp. 806-807
    • Brown, L.A.1    Hoog, J.2    Chin, S.F.3    Tao, Y.4    Zayed, A.A.5
  • 30
    • 33745160325 scopus 로고    scopus 로고
    • Evaluation of probe chemistries and platforms to improve the detection limit of real-time PCR
    • doi: 10.1016/j.mimet.2005.11.006
    • Reynisson E, Josefsen MH, Krause A, Hoorfar J, (2006) Evaluation of probe chemistries and platforms to improve the detection limit of real-time PCR. J Microbiol Methods 66: 206-216. doi:10.1016/j.mimet.2005.11.006. PubMed: 16364478.
    • (2006) J Microbiol Methods , vol.66 , pp. 206-216
    • Reynisson, E.1    Josefsen, M.H.2    Krause, A.3    Hoorfar, J.4
  • 31
    • 84859628318 scopus 로고    scopus 로고
    • ESR1 amplification in breast cancer: controversy resolved?
    • doi: 10.1002/path.3999
    • Albertson DG, (2012) ESR1 amplification in breast cancer: controversy resolved? J Pathol 227: 1-3. doi:10.1002/path.3999. PubMed: 22322671.
    • (2012) J Pathol , vol.227 , pp. 1-3
    • Albertson, D.G.1
  • 32
    • 84874656965 scopus 로고    scopus 로고
    • Clinical significance of ESR1 gene copy number changes in breast cancer as measured by fluorescence in situ hybridisation
    • 23268322
    • Lin CH, Liu JM, Lu YS, Lan C, Lee WC, et al. (2013) Clinical significance of ESR1 gene copy number changes in breast cancer as measured by fluorescence in situ hybridisation. J Clin Pathol, 66: 140-5. PubMed: 23268322.
    • (2013) J Clin Pathol , vol.66 , pp. 140-145
    • Lin, C.H.1    Liu, J.M.2    Lu, Y.S.3    Lan, C.4    Lee, W.C.5
  • 33
    • 46249093826 scopus 로고    scopus 로고
    • ESR1 gene amplification in breast cancer: a common phenomenon?
    • doi: 10.1038/ng0708-807
    • Horlings HM, Bergamaschi A, Nordgard SH, Kim YH, Han W, et al. (2008) ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet 40: 807-808. doi:10.1038/ng0708-807. PubMed: 18583965.
    • (2008) Nat Genet , vol.40 , pp. 807-808
    • Horlings, H.M.1    Bergamaschi, A.2    Nordgard, S.H.3    Kim, Y.H.4    Han, W.5
  • 34
    • 84858773315 scopus 로고    scopus 로고
    • Hormone treatment, estrogen receptor polymorphisms and mortality: a prospective cohort study
    • doi: 10.1371/journal.pone.0034112
    • Ryan J, Canonico M, Carcaillon L, Carrière I, Scali J, et al. (2012) Hormone treatment, estrogen receptor polymorphisms and mortality: a prospective cohort study. PLOS ONE 7: e34112. doi:10.1371/journal.pone.0034112. PubMed: 22457817.
    • (2012) PLOS ONE , vol.7
    • Ryan, J.1    Canonico, M.2    Carcaillon, L.3    Carrière, I.4    Scali, J.5
  • 35
    • 36349024762 scopus 로고    scopus 로고
    • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
    • doi: 10.1200/JCO.2007.12.2705
    • Schroth W, Antoniadou L, Fritz P, Schwab M, Muerdter T, et al. (2007) Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25: 5187-5193. doi:10.1200/JCO.2007.12.2705. PubMed: 18024866.
    • (2007) J Clin Oncol , vol.25 , pp. 5187-5193
    • Schroth, W.1    Antoniadou, L.2    Fritz, P.3    Schwab, M.4    Muerdter, T.5
  • 36
    • 61449171134 scopus 로고    scopus 로고
    • Genetic Polymorphisms of CYP2D6*10 and CYP2C19* 2,*3 Are not Associated With Prognosis, Endometrial Thickness, or Bone Mineral Density in Japanese Breast Cancer Patients Treated With Adjuvant Tamoxifen
    • doi: 10.1002/cncr.24111
    • Okishiro M, Taguchi T, Kim SJ, Shimazu K, Tamaki Y, et al. (2009) Genetic Polymorphisms of CYP2D6*10 and CYP2C19* 2,*3 Are not Associated With Prognosis, Endometrial Thickness, or Bone Mineral Density in Japanese Breast Cancer Patients Treated With Adjuvant Tamoxifen. Cancer 115: 952-961. doi:10.1002/cncr.24111. PubMed: 19156902.
    • (2009) Cancer , vol.115 , pp. 952-961
    • Okishiro, M.1    Taguchi, T.2    Kim, S.J.3    Shimazu, K.4    Tamaki, Y.5
  • 37
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • doi: 10.1038/nature09534
    • Altshuler DL, Durbin RM, Abecasis GR, Bentley DR, Chakravarti A, et al. (2010) A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073. doi:10.1038/nature09534. PubMed: 20981092.
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Altshuler, D.L.1    Durbin, R.M.2    Abecasis, G.R.3    Bentley, D.R.4    Chakravarti, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.