Preparation ofbromfenac-loaded liposomesmodified with chitosan for ophthalmic drug delivery and evaluation of physicochemical properties and drug release profile

Asian Journal of Pharmaceutical Sciences

Volumn 8, Issue 2, 2013, Pages 110-119

  Tsukamoto, Toshimasa ^a   Hironaka, Kohei ^a   Fujisawa, Takuya ^a   Yamaguchi, Daiki ^a   Tahara, Kohei ^a   Tozuka, Yuichi ^a,b   Takeuchi, Hirofumi ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Chitosan; Eye drop; NSAIDs; pH gradient method; Surface modification

Indexed keywords

ANION; BROMFENAC; CALCIUM ACETATE; CHITOSAN; DICETYL PHOSPHATE; LIPOSOME;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENCAPSULATION; LIPID COMPOSITION; PH; PHYSICAL CHEMISTRY;

EID: 84881322627     PISSN: 18180876     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Ahuja M, Dhake AS, Sharma SK, et al. Topical ocular delivery of NSAIDs. AAPS J. 2008, 10: 229-241.
2. Araujo J, Gonzalez E, Egea MA, et al. Nanomedicines for ocular NSAIDs: safety on drug delivery. Nanomedicine. 2009, 5: 394-401.
3. Shen J, Gan L, Zhu C, et al. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect. Int J Pharm. 2011, 412: 115-122.
4. Thrimawithana TR, Young S, Bunt CR, et al. Drug delivery to the posterior segment of the eye. Drug Discovery Today. 2011, 16: 270-277.
5. Bochot A, Fattal E. Liposomes for intravitreal drug delivery: A state of the art. J Controlled Release. 2012.
6. Eldaly MA, Styles C. First versus second eye intravitreal ranibizumab therapy for wet AMD. Retina. 2009, 29: 325-328.
7. Gan L, Wang J, Jiang M, et al. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discovery Today. 2012.
8. Del Amo EM, Urtti A. Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discovery Today. 2008, 13: 135-143.
9. Hironaka K, Inokuchi Y, Tozuka Y, et al. Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye. J Controlled Release. 2009, 136: 247-253.
10. Inokuchi Y, Hironaka K, Fujisawa T, et al. Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration. Invest Ophthalmol Vis Sci. 2010, 51: 3162-3170.
11. Sasaki H, Karasawa K, Hironaka K, et al. Retinal drug delivery using eyedrop preparations of poly-L-lysinemodified liposomes. Eur J Pharm Biopharm. 2012.
12. Fujisawa T, Miyai H, Hironaka K, et al. Liposomal diclofenac eye drop formulations targeting the retina: Formulation stability improvement using surface modification of liposomes. Int J Pharm. 2012, 436: 564-567.
13. Izume M, Ohtakara A. Preparation of D-Glucosamine Oligosaccharides by the Enzymatic Hydrolysis of Chitosan. Agric Biol Chem. 1987, 51: 1189-1191.
14. Hironaka K, Inokuchi Y, Fujisawa T, et al. Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage. Eur J Pharm Biopharm. 2011, 79: 119-125.
15. Chiu GN, Abraham SA, Ickenstein LM, et al. Encapsulation of doxorubicin into thermosensitive liposomes via complexation with the transition metal manganese. J Control Release. 2005, 104: 271-288.
16. Takeuchi H, Thongborisute J, Matsui Y, et al. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv Drug Deliv Rev. 2005, 57: 1583-1594.
17. Volodkin D, Mohwald H, Voegel JC, et al. Coating of negatively charged liposomes by polylysine: drug release study. J Control Release. 2007, 117: 111-120.
18. Li N, Zhuang C, Wang M, et al. Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int. J. Pharm. 2009, 379: 131-138.