No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression

European Archives of Psychiatry and Clinical Neuroscience

Volumn 263, Issue 5, 2013, Pages 405-412

  Musil, Richard ^a   Zill, Peter ^a   Seemüller, Florian ^a   Bondy, Brigitta ^a   Obermeier, Michael ^a   Spellmann, Ilja ^a   Bender, Wolfram ^b   Adli, Mazda ^c   Heuser, Isabella ^c   Zeiler, Joachim ^d   Gaebel, Wolfgang ^e   Maier, Wolfgang ^f   Rietschel, Marcella ^g   Rujescu, Dan ^a   Schennach, Rebecca ^a   Möller, Hans Jürgen ^a   Riedel, Michael ^a,h  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b KLINIKUM MÜNCHEN OST   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Vivantes Auguste Viktoria Klinikum   (Germany)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f UNIVERSITY OF BONN   (Germany)

^g CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^h Vincent von Paul Hospital   (Germany)

Author keywords

BDNF gene; Major depressive disorder; Pharmacogenetics; Treatment response

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; MONOAMINE OXIDASE INHIBITOR;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HAPLOTYPE MAP; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 84881314342     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-012-0364-1     Document Type: Article

References (43)

1. D'Sa C, Duman RS (2002) Antidepressants and neuroplasticity. Bipolar Disord 4:183-194 (Pubitemid 34591244)
2. Duman RS, Heninger GR, Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606 (Pubitemid 27306570)
3. Scharinger C, Rabl U, Pezawas L, Kasper S (2011) The genetic blueprint of major depressive disorder: contributions of imaging genetics studies. World J Biol Psychiatry 12:474-488
4. Campbell S, Macqueen G (2004) The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci 29:417-426 (Pubitemid 40075713)
5. Kanellopoulos D, Gunning FM, Morimoto SS, Hoptman MJ, Murphy CF, Kelly RE et al (2011) Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression. Am J Geriatr Psychiatry 19:13-22
6. Gonul AS, Kitis O, Eker MC, Eker OD, Ozan E, Coburn K (2011) Association of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patients. World J Biol Psychiatry 12:110-118
7. Eker C, Kitis O, Taneli F, Eker OD, Ozan E, Yucel K et al (2010) Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients. Eur Arch Psychiatry Clin Neurosci 260:527-533
8. Blugeot A, Rivat C, Bouvier E, Molet J, Mouchard A, Zeau B et al (2011) Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. J Neurosci 31:12889-12899
9. Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H (2012) Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 39(1):112-119
10. Wong ML, Dong C, Andreev V, Rcos-Burgos M, Licinio J (2012) Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. Mol Psychiatry 17:624-633
11. Kurita M, Nishino S, Kato M, Numata Y, Sato T (2012) Plasma brain-derived neurotrophic factor levels predict the clinical outcome of depression treatment in a naturalistic study. PLoS ONE 7:e39212
12. Dreimuller N, Schlicht KF, Wagner S, Peetz D, Borysenko L, Hiemke C et al (2012) Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression. Neuropharmacology 62:264-269
13. Papakostas GI, Shelton RC, Kinrys G, Henry ME, Bakow BR, Lipkin SH et al. (2011) Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a Pilot and Replication Study. Mol Psychiatry
14. Choi MJ, Kang RH, Lim SW, Oh KS, Lee MS (2006) Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. Brain Res 1118:176-182 (Pubitemid 44633860)
15. Gratacos M, Soria V, Urretavizcaya M, Gonzalez JR, Crespo JM, Bayes M et al (2008) A brain-derived neurotrophic factor (BDNF) haplotype is associated with antidepressant treatment outcome in mood disorders. Pharmacogenomics J 8:101-112 (Pubitemid 351411546)
16. Licinio J, Dong C, Wong ML (2009) Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry 66:488-497
17. Tsai SJ, Hong CJ, Liou YJ (2008) Brain-derived neurotrophic factor and antidepressant action: another piece of evidence from pharmacogenetics. Pharmacogenomics 9:1353-1358
18. Kato M, Serretti A (2010) Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry 15:473-500
19. Kocabas NA, Antonijevic I, Faghel C, Forray C, Kasper S, Lecrubier Y et al (2011) Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder. Int Clin Psychopharmacol 26:1-10
20. Domschke K, Lawford B, Laje G, Berger K, Young R, Morris P et al (2010) Brain-derived neurotrophic factor (BDNF) gene: no major impact on antidepressant treatment response. Int J Neuropsychopharmacol 13:93-101
21. Seemuller F, Riedel M, Obermeier M, Bauer M, Adli M, Kronmuller K et al (2010) Outcomes of 1014 naturalistically treated inpatients with major depressive episode. Eur Neuropsychopharmacol 20:346-355
22. Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278-296
23. Bauer M, Bschor T, Pfennig A, Whybrow PC, Angst J, Versiani M et al (2007) World federation of societies of biological psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders in primary care. World J Biol Psychiatry 8:67-104 (Pubitemid 46690921)
24. Bauer M, Whybrow PC, Angst J, Versiani M, Moller HJ (2002) World federation of societies of biological psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: acute and continuation treatment of major depressive disorder. World J Biol Psychiatry 3:5-43
25. American Psychiatric Association (2000) Practice guideline for the treatment of patients with major depressive disorder (revision). Am J Psychiatry 157(4 Suppl):1-45
26. Fava M, Rush AJ, Alpert JE, Balasubramani GK, Wisniewski SR, Carmin CN et al (2008) Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. Am J Psychiatry 165:342-351 (Pubitemid 351704490)
27. NCBI (2012) dbSNP databank. http://www.ncbi.nlm.nih.gov/projects/SNP/snp- ref.cgi?rs=7103411;rs=6265;rs=7124442. Accessed 19 Jul 2012
28. Purcell S, Cherny SS, Sham PC (2003) Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150 (Pubitemid 36150192)
29. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265 (Pubitemid 40202029)
30. Benjamini Y, Hochberg Y (2011) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc: Ser B (Methodol) 57:289-300
31. R Development Core Team (2011) R: a language and environment for statistical computing. Vienna. version: R 2.13.2; http://CRAN.R-project.org
32. Chen L, Lawlor DA, Lewis SJ, Yuan W, Abdollahi MR, Timpson NJ et al (2008) Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Am J Med Genet B Neuropsychiatr Genet 147B:814-821
33. Verhagen M (2010) van der MA, van Deurzen PA, Janzing JG, rias-Vasquez A, Buitelaar JK et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 15:260-271
34. Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N et al (2011) DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS ONE 6:e23881
35. Gatt JM, Kuan SA, Dobson-Stone C, Paul RH, Joffe RT, Kemp AH et al (2008) Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. Biol Psychol 79:275-284
36. Gatt JM, Nemeroff CB, Schofield PR, Paul RH, Clark CR, Gordon E et al (2010) Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. Biol Psychiatry 68:818-824
37. Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RA, Schofield PR et al (2009) Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry 14:681-695
38. Pezawas L, Meyer-Lindenberg A, Goldman AL, Verchinski BA, Chen G, Kolachana BS et al (2008) Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry 13:709-716 (Pubitemid 351861533)
39. Czira ME, Wersching H, Baune BT, Berger K (2011) Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population. Age. doi: 10.1007/s11357-011-9313-6
40. Zou YF, Ye DQ, Feng XL, Su H, Pan FM, Liao FF (2010) Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. Eur Neuropsychopharmacol 20:535-544
41. Juckel G, Schumacher C, Giegling I, Assion HJ, Mavrogiorgou P, Pogarell O et al (2010) Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene. J Psychiatr Res 44:541-546
42. Bocchio-Chiavetto L, Miniussi C, Zanardini R, Gazzoli A, Bignotti S, Specchia C et al (2008) 5-HTTLPR and BDNF Val66Met polymorphisms and response to rTMS treatment in drug resistant depression. Neurosci Lett 437:130-134
43. Uher R, Dernovsek MZ, Mors O, Hauser J, Souery D, Zobel A et al (2011) Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline. J Affect Disord 132:112-120