T-cell response against varicella-zoster virus in fingolimod-treated MS patients

Neurology

Volumn 81, Issue 2, 2013, Pages 174-181

  Ricklin, Meret E ^a   Lorscheider, Johannes ^a,c   Waschbisch, Anne ^d   Paroz, Cecile ^a   Mehta, Satish K ^e   Pierson, Duane L ^a   Kuhle, Jens ^a,c   Fischer Barnicol, Bettina ^c   Sprenger, Till ^b,c   Lindberg, Raija L P ^a   Kappos, Ludwig ^a,c   Derfuss, Tobias ^a,c  

^a Department of Biomedicine   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CD137 ANTIGEN; CD69 ANTIGEN; FINGOLIMOD; GAMMA INTERFERON;

ADULT; ARTICLE; CD3+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; EPSTEIN BARR VIRUS; FEMALE; FLOW CYTOMETRY; HERPES ZOSTER; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SALIVA ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; VARICELLA ZOSTER VIRUS; VIRUS REPLICATION;

ADULT; AGED; DRUG ADMINISTRATION SCHEDULE; FEMALE; HERPES ZOSTER; HERPESVIRUS 3, HUMAN; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-BETA; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROPYLENE GLYCOLS; SALIVA; SPHINGOSINE; T-LYMPHOCYTES; VIRUS ACTIVATION;

EID: 84881265170     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31829a3311     Document Type: Article

References (17)

1. Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004;4: 1019-1025
2. Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 2007;8: 1295-1301
3. Kowarik MC, Pellkofer HL, Cepok S, et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. Neurology 2011;76: 1214-1221
4. Ingwersen J, Aktas O, Kuery P, Kieseier B, Boyko A, Hartung HP. Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy. Clin Immunol 2012;142:15-24
5. Pinschewer DD, Brinkmann V, Merkler D. Impact of sphingosine 1-phosphate modulation on immune outcomes. Neurology 2011;76:S15-S19
6. Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-415
7. Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355:1124-1140
8. Sotelo J, Corona T. Varicella zoster virus and relapsing remitting multiple sclerosis. Mult Scler Int 2011;2011:214763.
9. Mehta SK, Cohrs RJ, Forghani B, Zerbe G, Gilden DH, Pierson DL. Stress-induced subclinical reactivation of varicella zoster virus in astronauts. J Med Virol 2004;72:174-179
10. Cohrs RJ, Randall J, Smith J, et al. Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using realtime PCR. J Virol 2000;74:11464-11471
11. Nash RA, Bowen JD, McSweeney PA, et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood 2003;102:2364-2372
12. Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology 2008;71:1261-1267
13. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004;22:745-763
14. Mehling M, Hilbert P, Fritz S, et al. Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients. Ann Neurol 2011;69:408-413
15. Gershon AA, Gershon MD, Breuer J, Levin MJ, Oaklander AL, Griffiths PD. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. J Clin Virol 2010;48(suppl 1):S2-S7
16. Hufner K, Derfuss T, Herberger S, et al. Latency of alphaherpes viruses is accompanied by a chronic inflammation in human trigeminal ganglia but not in dorsal root ganglia. J Neuropathol Exp Neurol 2006;65:1022-1030
17. Sotelo J, Martinez-PalomoA,Ordonez G, Pineda B. Varicellazoster virus in cerebrospinal fluid at relapses of multiple sclerosis. Ann Neurol 2008;63:303-311