Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

Cochrane Database of Systematic Reviews

Volumn 2012, Issue 1, 2012, Pages

  Gafter Gvili, Anat ^a   Fraser, Abigail ^b   Paul, Mical ^c   Vidal, Liat ^a   Lawrie, Theresa A ^d   van de Wetering, Marianne D ^e   Kremer, Leontien C M ^e   Leibovici, Leonard ^a  

^a RABIN MEDICAL CENTER   (Israel)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c Division of Infectious Diseases   (Israel)

^d ROYAL UNITED HOSPITAL   (United Kingdom)

^e EMMA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; COTRIMOXAZOLE; QUINOLONE DERIVATIVE;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; BACTEREMIA; BACTERIAL INFECTION; CAUSE OF DEATH; CHEMICALLY INDUCED DISORDER; FEVER; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HUMAN; META ANALYSIS; MORTALITY; NEOPLASM; NEUTROPENIA; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; BACTEREMIA; BACTERIAL INFECTIONS; CAUSE OF DEATH; DRUG RESISTANCE, BACTERIAL; FEVER; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; NEOPLASMS; NEUTROPENIA; QUINOLONES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 84862639370     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD004386.pub3     Document Type: Review

References (225)

1. Archimbaud E, Guyotat D, Maupas J, Ploton C, Nageotte A, Devaux Y, et al. Pefloxacin and vancomycin vs. gentamicin, colistin sulphate and vancomycin for prevention of infections in granulocytopenic patients: a randomised double-blind study. European Journal of Cancer 1991;27:174-8.
2. Arning M, Wolf H, Aul C, Heyll A, Scharf R, Scheider W. Infection prophylaxis in neutropenic patients with acute leukaemia--a randomised, comparative study with ofloxacin, ciprofloxacin and co-trimoxazole/colistin. Journal of Antimicrobial Chemotherapy 1990;26 Suppl D:137-42.
3. Attal M, Schlaifer D, Rubie H, Huguet F, Charlet J, Bloom E, et al. Prevention of gram-positive infections after bone marrow transplantation by systemic vancomycin: a prospective, randomised trial. Journal of Clinical Oncology 1991; Vol. 9:865-70.
4. Bartoloni AF, Orsi A, Aquilini D, Bosi A, Rossi Ferrini P, Paradisi F. The influence of ofloxacin versus trimethoprim-sulfamethoxazole on the aerobic flora in granulocytopenic subjects. Journal of Chemotherapy 1989;1:91-4.
5. Bender JF, SchimpffSC, Young VM, Fortner CL, Brouillet MD, Love LJ, et al. Role of vancomycin as a component of oral nonabsorbable antibiotics for microbial suppression in leukemic patients. Antimicrobial Agents and Chemotherapy 1979;15(3):455-60.
6. Bow EJ, Louie TJ, Riben PD, McNaughton RD, Harding GK, Ronald AR. Randomized controlled trial comparing trimethoprim/sulfamethoxazole and trimethoprim for infection prophylaxis in hospitalized granulocytopenic patients. American Journal of Medicine 1984;76:223-33.
7. Riben PD, Louie JT, Lank BA, Kornachuk E, Gurwith MJ, Harding GKM, et al. Reduction in mortality from gram-negative sepsis in neutropenic patients receiving trimethoprim-sulfamethoxazole therapy. Cancer 1983;51:1587-92.
8. Bow EJ, Raynor E, Thomas JL. Comparison of norfloxacin with cotrimoxazole for infection prophylaxis in acute leukemia. The trade-offfor reduced gram-negative sepsis. American Journal of Medicine 1988;84:847-54.
9. Bow EJ, Mandell LA, Thomas JL, Feld R, Palmer M, Zee B, et al. Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effect of augmented gram-positive activity on infectious morbidity. National Cancer Institute of Canada Clinical Trials Group. Annals of Internal Medicine 1996;125(3):183-90.
10. Brodsky AL, Melero MJ, Sanchez Avalos JC. Prophylaxis with fluoroquinolones in patients with neutropenia. Medicina 1993;53:401-7.
11. Broun ER, Wheat JL, Kneebone PH, Sundblad K, Hromas RA, Guido T. Randomized trial of the addition of gram-positive prophylaxis to standard antimicrobial prophylaxis for patients undergoing autologous bone marrow transplantation. Antimicrobial Agents and Chemotherapy 1994;38(3):576-9.
12. Bucaneve G, Micozzi A, Menichetti F, Martino P, Stella Dionosi M, Martinelli G, et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. New England Journal of Medicine 2005;353(10):977-87.
13. Micozzi A, Bucaneve O, Martino P, Menichetti F, Del Favero A, GIMEMA Infection Program. Levofloxacin compared to placebo for preventing infection in neutropenic cancer patients in a multi-centre, double-blind, randomised, controlled trial. Abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2004 October 30-November 2 Washington DC, USA. 2004:Abstract L-991.
14. Carlson JW, Fowler JM, Mitchell SK, Carson LF, Mayer AR, Copelands LJ. Chemoprophylaxis with ciprofloxacin in ovarian cancer patients receiving paclitaxel: a randomised trial. Gynecologic Oncology 1997;65:325-9.
15. Casali A, Verri C, Paoletti G, Tropea F, Modugno G, Frasca AM, et al. Chemoprophylaxis of bacterial infections in granulocytopenic cancer patients using norfloxacin. Chemioterapia 1988;7:327-9.
16. Boni L, Castagnola E, Giacchino M, Cesaro S, De Sio L, Garaventa A, et al. Amoxicillin-Clavulanate (AC) Vs Placebo (PB) in the Prevention of Febrile Neutropenia in Children with Cancer. Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2000 September Toronto. 2000:Abstract 727:473.
17. Castagnola E, Boni L, Giacchino M, Cesaro S, De Sio L, Garaventa A, et al. A multicentre, randomised, double blind placebo-controlled trial of amoxicillin/clavulanate for the prophylaxis of fever and infection in neutropenic children with cancer. Pediatric Infectious Disease Journal 2003;22(4):359-65.
18. Chastagner P, Leverger G, Perel Y, Lamagnere JP, Bergeron C, Vannier JP, et al. Prevention of gram positive infections with teicoplanin during the induction therapy of childhood acute lymphoblastic leukemia (ALL): results of a prospective randomised trial. Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1997 Sept 28-Oct 1; Toronto. 1997:Abstract LM-58b.
19. Chung DR, Kim YS, Kim EO, JH Woo, Ryu JS. Prophylaxis with Tosufloxacin during Periods of Granulocytopenia in Patients with Acute Leukemia. Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1997 September 28-October 1; Toronto. 1997:Abstract LM-58a.
20. Cruciani M, Concia E, Navarra A, Perversi L, Bonetti F, Arico M, et al. Prophylactic co-trimoxazole versus norfloxacin in neutropenic children--perspective randomised study. Infection 1989;17:65-9.
21. Cullen M, Steven N, Billingham L, Gaunt C, Hastings M, Simmonds P, et al. Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. New England Journal of Medicine 2005;353(10):988-98.
22. D'Antonio D, Iacone A, Fioritoni G, Betti S, DiGirolamo A, Piccolomini R, et al. Antibacterial prophylaxis in granulocytopenic patients: A randomised study of ofloxacin versus norfloxacin. Currrent Therapeutic Research 1991;50:304-11.
23. D'Antonio D, Iacone A, Fioritoni G, Betti S, Dell'Isola M, Quaglietta AM, et al. Comparison of norfloxacin and pefloxacin in the prophylaxis of bacterial infection in neutropenic cancer patients. Drugs Under Experimental & Clinical Research 1992;18:141-6.
24. D'Antonio D, Piccolomini R, Iacone A, Fioritoni G, Parruti G, Betti S, et al. Comparison of ciprofloxacin, ofloxacin and pefloxacin for the prevention of the bacterial infection in neutropenic patients with haematological malignancies. Journal of Antimicrobial Chemotherapy 1994;33:837-44.
25. de Jongh CA, Wade JC, Finley RS, Joshi JH, Aisner J, Wiernik PH, et al. Trimethoprim/sulfamethoxazole versus placebo: a double-blind comparison of infection prophylaxis in patients with small cell carcinoma of the lung. Journal of Clinical Oncology 1983;1:302-7.
26. Dekker AW, Rozenberg, Arska M, Sixma JJ, Verhoef J. Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. Annals of Internal Medicine 1981;95:555-9.
27. Verhoef J, Rozenberg-Arska M, Dekker A. Prevention of infection in the neutropenic patient. Reviews of Infectious Diseases 1989;11 Suppl 7:1545-50.
28. Dekker AW, Rozenberg, Arska M, Verhoef J. Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. Annals of Internal Medicine 1987;106:7-11.
29. Dickgreber N. Nagel S. Roscher K. Schuette W. Randomised, placebo-controlled phase III. trial of docetaxel plus carboplatin with or without levofloxacin prophylaxis in elderly patients with advanced non-small cell lung cancer: The APRONTA Trial [19th European Congress of Clinical Microbiology and Infectious Diseases]. Clinical Microbiology and Infection. 2009; Vol. 15:S519.
30. Donnelly JP, Maschmeyer G, Daenen S. Selective oral antimicrobial prophylaxis for the selective oral antimicrobial prophylaxis for the pevention of infection in acute leukaemia-ciprofloxacin versus co-trimoxazole plus colistin. The EORTC-Gnotobiotic Project Group. European Journal of Cancer 1992;28A:873-8.
31. Verhoef J, Rozenberg-Arska M, Dekker A. Prevention of infection in the neutropenic patient. Reviews of Infectious Diseases 1989;11(suppl 7):1545-50.
32. Enno A, Catovsky D, Darrell J, Goldman JM, Hows J, Galton DA. Co-trimoxazole for prevention of infection in acute leukaemia. Lancet 1978;2:395-7.
33. EORTC International Antimicrobial Therapy Project Group. Trimethoprim-sulfamethoxazole in the prevention of infection in neutropenic patients. EORTC International Antimicrobial Therapy Project Group. Journal of Infectious Diseases 1984;150:372-9.
34. nternational Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. Reduction of fever and streptococcal bacteraemia in granulocytopenic patients with cancer: a trial of oral penicillin v or placebo combined with pefloxacin. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. JAMA 1994;272(15):1183-9.
35. Estey E, Maksymiuk A, Smith T, Fainstein V, Keating M, McCredie KB, et al. Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. Archives of Internal Medicine 1984;144(8):1562-8.
36. Fanci R, Leoni F, Bosi A, Guidi S, Ciolli S, Longo G, et al. Chemoprophylaxis of bacterial infections in granulocytopenic patients with ciprofloxacin vs ciprofloxacin plus amoxicillin. Journal of Chemotherapy 1993;5:119-23.
37. Ford CD, Reilly W, Wood J, Classen DC, Burke JP. Oral antimicrobial prophylaxis in bone marrow transplant recipients: randomised trial of ciprofloxacin versus ciprofloxacin-vancomycin. Antimicrobial Agents and Chemotherapy 1998;42:1402-5.
38. García-Sáenz JA, Martín M, Casado A, Pérez-Segura P, Manrique I, Flores L, et al. Immediate vs. delayed imipenem treatment in cancer patients with profound neutropenia induced by high-dose chemotherapy:Results of a randomised study [Tratamiento inmediato o tardío con imipenemen pacientes con cáncer y neutropenia por quimioterapia a dosis altas:Resultados de un estudio comparativo aleatorizado]. Rev Esp Quimioterap 2002;15(3):257-63.
39. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto. Prevention of bacterial infection in neutropenic patients with hematologic malignancies. A randomised, multicentre trial comparing norfloxacin with ciprofloxacin. The GIMEMA Infection Program. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto. Annals of Internal Medicine 1991;115:7-12.
40. Gluckman E, Cavazzana M, Devergie A, Meletis J, Arlet G, Perol Y, et al. Prevention of bacterial infections after bone marrow graft by broad-spectrum oral antibiotics, absorbable (pefloxacin, penicillin) and non absorbable (cephalosporin, gentamycin, bacitracin) [Prevention des infections bacteriennes apres greffe de moelle osseuse par antibiotique oraux a large spectre absorbables (pefloxacine, penicilline) ou non absorbables (cephalosporine, gentamicine, bacitracine)]. Pathologie Biologie 1988;36(7):902-6.
41. Gluckman E, Roudet C, Hirsch I, Devergie A, Bourdeau H, Arlet C, et al. Prophylaxis of bacterial infections after bone marrow transplantation. A randomised prospective study comparing oral broad-spectrum nonabsorbable antibiotics (vancomycin-tobramycin-colistin) to absorbable antibiotics (ofloxacin-amoxicillin). Chemotherapy 1991;37 Suppl 1:33-8.
42. Gomez-Martin C, Sola C, Hornedo J, Perea S, Lumbreras C, Valenti V, et al. Rifampin does not improve the efficacy of quinolone antibacterial prophylaxis in neutropenic cancer patients: results of a randomised clinical trial. Journal of Clinical Oncology 2000;18:2126-34.
43. Goorin AM, Hershey BJ, Levin MJ, Siber GR, Gelber RD, Flynn K, et al. Use of trimethoprim-sulfamethoxazole to prevent bacterial infections in children with acute lymphoblastic leukemia. Pediatric Infectious Disease 1985;4(3):265-9.
44. Gualtieri RJ, Donowitz GR, Kaiser Dl, Hess CE, Sande MA. Double-blind randomised study of prophylactic trimethoprim/sulfamethoxazole in granulocytopenic patients with hematologic malignancies. American Journal of Medicine 1983;74:934-40.
45. Guiot HF, van den Broek PJ, van der Meer JW, van Furth R. Selective antimicrobial modulation of the intestinal flora of patients with acute nonlymphocytic leukemia: a double-blind, placebo-controlled study. Journal of Infectious Diseases 1983;147:615-23.
46. Guiot HF, van der Meer JWM, van den Broek PJ, Willemze R, van Furth R. Prevention of viridans-group streptococcal septicemia in oncohematologic patients: a controlled comparative study on the effect of penicillin G and cotrimoxazole. Annals of Hematology 1992;64:260-5.
47. Gurwith MJ, Brunton JL, Lank BA, Harding GK, Ronald AR. A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. American Journal of Medicine 1979;66:248-56.
48. Hargadon MT, Young VM, SchimpffSC, Wade JC, Minah GE. Selective suppression of alimentary tract microbial flora as prophylaxis during granulocytopenia. Antimicrobial Agents & Chemotherapy 1981;20:620-4.
49. Harousseau JL, Milpied N, Reynaud AE. Antibiotic prophylaxis with ceftriaxone for severe and durable neutropenia [Utilisation de la ceftriaxone en prophylaxie des infections bacteriennes au cours des]. Medecine et Maladies Infectieuses 1989;19:91-5.
50. Harousseau Jl, Milpied N, Reynaud AE, Derriennic M, Bourhis JH, Courtieu AL. Preventive systemic antibiotherapy with ceftriaxone alone in neutropenic patients treated in a protected environment. [French]. La Presse Medicale 1987;16:1737-40.
51. Hartlapp JH. Antimicrobial prophylaxis in immunocompromised patients. Drugs 1987;34 Suppl 1:131-3.
52. Henry SA, Armstrong D, Kempin S, Gee T, Arlin Z, Clarkson B. Oral trimethoprim/sulfamethoxazole in attempt to prevent infection after induction chemotherapy for acute leukemia. American Journal of Medicine 1984;77:663-6.
53. Hidalgo M, Hornedo J, Lumbreras C, Trigo JM, Gomez C, Perea S, et al. Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants. Antimicrobial Agents & Chemotherapy 1997;41:1175-7.
54. Inoue M, Arai S, Kawamura Y, Kamiya H, Sakurai M, Izawa T, et al. The prophylactic effect of trimethoprim-sulfamethoxazole on infections in children with acute leukaemia. Drugs Under Experimental and Clinical Research 1983;9:35-43.
55. Jansen J, Cromer M, Akard L, Black JR, Wheat J. Infection prevention in severely myelosuppressed patients: a comparison between ciprofloxacin and a regimen of selective antibiotic modulation of the intestinal flora. American Journal of Medicine 1994;96:335-41.
56. Jehn U, Ruckdeschel G, Sauer H, Clemm C, Wilmanns W. Comparative study on the value of selective decontamination of the digestive tract in acute leukemia patients (author's transl)]. [German]. Klinische Wochenschrift 1981;59:1093-9.
57. Karp JE, Merz WG, Hendricksen C, Laughon B, Redden T, Bamberger BJ, et al. Infection Management during antileukemic treatment-induced granulocytopenia: the role for oral norfloxacin prophylaxis against infections arising from gastrointestinal tract. Scandinavian Journal of Infectious Diseases 1986;Suppl 48:66-78.
58. Karp JE, Merz WG, Hendricksen C, Laughon B, Redden T, Bamberger BJ, et al. Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia. A randomised, double-blind, placebo-controlled trial. Annals of Internal Medicine 1987;106:1-7.
59. Kauffman CA, Liepman MK, Bergman AG, Mioduszewski J. Trimethoprim/sulfamethoxazole prophylaxis in neutropenic patients. Reduction of infections and effect on bacterial and fungal flora. The American Journal of Medicine 1983;74:599-607.
60. Kern W, Kurrle E. Ofloxacin versus trimethoprim-sulfamethoxazole for prevention of infection in patients with acute leukemia and granulocytopenia. Infection 1991;19:73-80.
61. Kern WV, Hay B, Kern P, Marre R, Arnold R. A randomised trial of roxithromycin in patients with acute leukemia and bone marrow transplant recipients receiving fluoroquinolone prophylaxis. Antimicrobial Agents and Chemotherapy 1994;38:465-72.
62. Klastersky J, Debusscher L, Weerts D, Daneau D. Use of oral antibiotics in protected units environment: clinical effectiveness and role in the emergence of antibiotic-resistant strains. Pathologie Biologie 1974;22(1):5-12.
63. Kovatch AL, Wald ER, Albo VC, Prin W, Orlando SJ, Wollman MR, et al. Oral trimethoprim-sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics 1985;76(5):754-60.
64. Kramer BS, Carr DJ, Rand KH, Pizzo PA, Johnson A, Robichaud KJ, et al. Prophylaxis of fever and infection in adult cancer patients. A placebo-controlled trial of oral trimethoprim-sulfamethoxazole plus erythromycin. Cancer 1984;53(2):329-35.
65. Kurrle E, Bhaduri S, Pfleiger H, Heimpel H. Antimicrobial prophylaxis in acute leukemia: prospective randomised study comparing two methods of selective decontamination. Klinische Wochen-schrift 1983;61:691-8.
66. Kurrle E, Dekker AW, Gaus W, Harlambie E, Krieger M, Rozenberg-Arska M et al (EORTC writing committee). Prevention of infection in acute leukemia: a prospective randomised study on the efficacy of two different drug regimens for antimicrobial prophylaxis. Infection 1986;14(5):226-32.
67. Lalami Y, Paesmans M, Aoun M, Munoz-Bermeo R, Reuss K, CherifiS, et al. A prospective randomised evaluation of G-CSF or G-CSF plus oral antibiotics in chemotherapy-treated patients at high risk of developing febrile neutropenia. Support Care Cancer 2004;12:725-30.
68. Lamy T, Michelet C, Dauriac C, Grulois I, Donio PY, Le Prise PY. Benefit of prophylaxis by intravenous systemic vancomycin in granulocytopenic patients: a prospective, randomised trial among 59 patients. Acta Haematologica 1993;90:109-13.
69. Lange B, Halpern S, Gale G, Kramer S. Trimethoprim-sulfamethoxazole and nystatin prophylaxis in children with acute lymphoblastic leukemia. European Paediatric Haematology and Oncology 1984;1:231-8.
70. Lee DG, Choi SM, Choi JH, Yoo JH, Park YH, Kim YJ, et al. Selective bowel decontamination for the prevention of infection in acute myelogenous leukemia: a prospective randomised trial. Korean Journal of Internal Medicine 2002;17(1):38-44.
71. Levine AS, Seigel SE, Schreiber AD, Hauser J, Preisler H, Goldstein IM, et al. Protected environments and prophylactic antibiotics. A prospective controlled study of their utility in the therapy of acute leukemia. New England Journal of Medicine 1973;288:477-83.
72. Lew MA, Kehoe K, Ritz J, Antman Kh, Nadler L, Takvorian T, et al. Prophylaxis of bacterial infections with ciprofloxacin in patients undergoing bone marrow transplantation. Transplantation 1991;51:630-6.
73. Lew MA, Kehoe K, Ritz J, Antman KH, Nadler L, Kalish LA, et al. Ciprofloxacin versus trimethoprim/sulfamethoxazole for prophylaxis of bacterial infections in bone marrow transplant recipients: a randomised, controlled trial. Journal of Clinical Oncology 1995;13:239-50.
74. Liang RH, Yung RWH, Chan TK, Chau PY, Lam WK, So SY, et al. Ofloxacin versus co-trimoxazole for prevention of infection in neutropenic patients following cytotoxic chemotherapy. Antimicrobial Agents & Chemotherapy 1990;34:215-8.
75. Maiche AG, Muhonen T. Granulocyte colony-stimulating factor (G-CSF) with or without a quinolone in the prevention of infection in cancer patients. European Journal of Cancer 1993;29A(10):1403-5.
76. Malarme M, Meunier-Carpentier F, Klastersky J. Vancomycin plus gentamicin and cotrimoxazole for prevention of infections in neutropenic cancer patients (a comparative, placebo-controlled pilot study). European Journal of Cancer and Clinical Oncology 1981;17:1315-22.
77. Martino P, Venditti M, Petti MC, Mandelli F, Serra P. Cotrimoxazole prophylaxis in patients with leukemia and prolonged granulocytopenia. American Journal of the Medical Sciences 1984;287:7-9.
78. Maschmeyer G, Haralambie E, Gaus W, Kern W, Dekker AW, De Vries-Hospers HG, et al. Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia. Infection 1988;16:98-104.
79. Mocikova K, Svac J, Faber E, Wildova B, Banikova I. Comparison of Tarivid and Biseptol in the prevention of bacterial infections in patients with acute leukemia. Vnitrni Lekarstvi 1992;38(2):166-72.
80. Moreau P, Milplied N, Richard P, Bulbois CE, Richet H, Harousseau JL. Prospective randomised study comparing prophylactic ciprofloxacin (C) and amoxicillin + clavulanic acid (A-CA) vs prophylactic vancomycin (V) vs non prophylactic conventional empiric antimicrobial therapy in neutropenic patients [abstract]. Bone Marrow Transplantation. 1995; Vol. 15 Suppl 2:129.
81. Moriuchi Y, Kamihira S, Yamamura M, Mori H, Miyazaki Y, Tokunaga S, et al. Comparison of ciprofloxacin with polymyxin B for infection prophylaxis in neutropenic patients with acute non-lymphocytic leukemia. Japanese Journal of Clinical Hematology 1990;31:1664-9.
82. Murase T. Chemoprophylaxis of bacterial infections in granulocytopenic patients with new quinolone: a comparison of trimethoprim-sulfamethoxazole (ST) alone with ST plus ciprofloxacin. Journal of the Japanese Association for Infectious Diseases 1995;69:28-32.
83. Nemet D, Kalenic S, Badanjak A, Bogdanic V, Davila N, Francetic I, et al. Prevention of gram-negative bacterial infection in granulocytopenic patients: a randomised study comparing oral norfloxacin with gentamycin. Bone Marrow Transplantation 1989;4(Suppl 3):105.
84. Nenova IS, Ananostev NH, Goranov, SE, Mateva NG, Haidushka IA. Fluoroquinolone prophylaxis for bacterial infections in neutropenic patients with hematologic malignancies. Folia Medica Plovdiv 2001;43(4):40-5.
85. Orlandi E, Navarra A, Cruciani M, Caldera D, Morra E, Castagnola C, et al. Norfloxacin versus cotrimoxazole for infection prophylaxis in granulocytopenic patients with acute leukemia. A prospective randomised study. Haematologica 1990;75:296-8.
86. Eleutherakis-Papaiakovou E, Kostis E, Migkou M, Christoulas D, Terpos E, Gavriatopoulou M, et al. Prophylactic antibiotics for the prevention of neutropenic fever in patients undergoing autologous stem-cell transplantation: Results of a single institution, randomised phase 2 trial. American Journal of Hematology 2010;85(11):863-7.
87. Patrick CC, Adair JR, Warner WC Jr, Church DA, Sanders RH, Krance R, et al. Safety of Ciprofloxacin as a Prophylactic Agent for Prevention of Bacterial Infections in Pediatric Bone Marrow Transplant (BMT) Patients. Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1995 October; San Francisco. 1995:Abstract LM32.
88. Petersen FB, Buckner CD, Clift RA, Lee S, Nelson N, Counts GW, et al. Laminar air flow isolation and decontamination: a prospective randomised study of the effects of prophylactic systemic antibiotics in bone marrow transplant patients. Infection 1986;14(3):115-21.
89. Pignon B, Thiriet L, Aubert D, Pennaforte JL, Vilque JP, Lartigue B, et al. Evaluation of the efficacy of prophylactic intravenous antibiotherapy with ceftriaxone in post-chemotherapy agranulocytic patients. Nouvelle Revue Francaise d'Hematologie 1990;32(4):249-52.
90. Pizzo PA, Robichaud K, Edwards BK, Schumaker C, Kramer BS, Johnson A. Oral antibiotic prophylaxis in patients with cancer: a double-blind randomised placebo-controlled trial. Journal of Pediatrics 1983;102:125-33.
91. Prentice HG, Hann IM, Nazareth B, Paterson P, Bhamra A, Kibbler CC. Oral ciprofloxacin plus colistin: prophylaxis against bacterial infection in neutropenic patients. A strategy for the prevention of emergence of antimicrobial resistance. British Journal of Haematology 2001;115:46-52.
92. Rafecas FJ, Gil E, Martin G, Martinez J, Sanz G, Sempere A, et al. Oral ciprofloxacin in the prophylaxis of bacterial infection in neutropenic patients. A randomized, double-blind, comparative clinical study [Ciprofloxacina oral en la profilaxis de la infeccion bacteriana en pacientes neutropenicos. Ensayo clinico aleatorio, doble ciego y comparativo vs. placebo]. Rev Esp Quimioter 1989;2(2):174-7.
93. Rahman MM, Khan MA. Levofloxacin prophylaxis to prevent bacterial infection in chemotherapy-induced neutropenia in acute leukemia. Bangladesh Medical Research Council Bulletin 2009;35:91-4.
94. Ruiz I, Fuentes I, Capdevila JA, Juli A, Carreras J, Pahissa A, et al. Ofloxacin Prophylaxis in Preventing Bacterial Infection after Autologous Peripheral Blood Stem Cell Transplantation (A-PBSC). Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; 2001 September and December; Chicago. 2001:Abstract L-781:447.
95. Sampi K, Maseki N, Hattori M. [A comparison of nystatin with norfloxacin for prevention of infection after consolidation therapy in patients with acute leukemia or autologous bone marrow transplantation: a randomised study]. Gan To Kagaku Ryoho 1992;19(6):823-6.
96. SchimpffSC, Greene WH, Young VM, Fortner CL, Cusack N, Block JB, et al. Infection prevention in acute nonlymphocytic leukemia. Laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis. Annals of Internal Medicine 1975;82(3):351-8.
97. Schroeder M, Schadeck-Gressel C, Selbach J, Westerhausen M. Antibiotic prophylaxis with gyrase inhibitors during cytostatically induced granulocytopenias in patients with solid tumors: A double-blind prospective randomised study. Onkologie 1992;15:476-9.
98. Slavin MA, Grigg AP, Schwarer AP, Szer J, Spencer A, Sainani A, et al. A randomised comparison of empiric or pre-emptive antibiotic therapy after hematopoietic stem cell transplantation. Bone Marrow Transplantation 2007;40:157-163.
99. Sleijfer DT, Mulder NH, de Vries-Hospers HG, Fidler V, Nieweg HO, van der Waaij D, et al. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. European Journal of Cancer 1980;16:859-69.
100. de Vries H, Sleijfer DT, Mulder NH, van der Waaj D, Nieweg OH, van Saene HKF. Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Antimicrobial Agents & Chemotherapy 1981;19(5):813-20.
101. Starke ID, Donnely P, Catovsky D, Darrell J, Johnson SA, Goldman JM, et al. Co-trimoxazole alone for prevention of bacterial infection in patients with acute leukaemia. Lancet 1982;1(8262):5-6.
102. Talbot GH, Cassileth GH, Paradiso L, Correa-Coronas R, Bond L. Oral enoxacin for infection prevention in adults with acute nonlymphocytic leukemia. The Enoxacin Prophylaxis Study Group. Antimicrobial Agents and Chemotherapy 1993;3:474-82.
103. Teinturier C, Hartmann O, Lemerle J, Benhamou E, Maraninchi D. Prevention of gram-positive infections in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomised controlled trial of vancomycin. Pediatric Hematology and Oncology 1995;12(1):73-7.
104. Thomas X, Troncy J, Belhabri A, Thiebaut A, Bouheddou N, Michallet M, et al. Effectiveness of combined vancomycin and pefloxacine in gastrointestinal decontamination for preventing infections after chemotherapy-induced bone marrow aplasia. A randomised double-blind study. La Presse Medicale 2000;29(32):1745-51.
105. Timmers GJ, Simoons-Smit AM, Leidekker ME, Janssen JJWM, Vandenbroucke-Grauls CMJE, Huijgens PC. Levofloxacin vs. ciprofloxacin plus phenethicillin for the prevention of bacterial infections in patients with haematological malignancies. Clinical Microbiology and Infection 2007;13(5):497-503.
106. Tjan Heijnen VCG, Postmus PE, Ardizzoni A, Manegold Ch, Burghouts J, van Meerbeeck J, et al. Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III. study. Annals of Oncology 2001;12(10):1359-68.
107. Tsutani H, Imamura S, Ueda T, Yoshida H, Iwasaki H, Fukushima T. Prophylactic use of ofloxacin in granulocytopenic patients with hematological malignancies during post-remission chemotherapy. Internal Medicine 1992;31:319-24.
108. van Eys J, Berry DM, Crist W, Doering EJ, Fernbach DJ, Pullen J, et al. Effect of trimethoprim/sulfamethoxazole prophylaxis on outcome of childhood lymphocytic leukemia. A Pediatric Oncology Group Study. Cancer 1987;1(59):19-23.
109. Wade JC, SchimpffSC, Hargadon MT, Fortner CL, Wiernik PH. A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. New England Journal of Medicine 1981;304(18):1057-62.
110. Wade JC, de Jongh CA, Newman KA, Crowley J, Wiernik PH, SchimpffSC. Selective antimicrobial modulation as prophylaxis against infection during granulocytopenia: trimethoprim-sulfamethoxazole vs. nalidixic acid. Journal of Infectious Diseases 1983;147:624-34.
111. Ward TT, Thomas RG, Fye CL, Arbeit R, Coltman CA Jr, Craig W, et al. Trimethoprim-sulfamethoxazole prophylaxis in granulocytopenic patients with acute leukemia: evaluation of serum antibiotic levels in a randomised, double-blind, placebo-controlled Department of Veterans Affairs Cooperative Study. Clinical Infectious Diseases 1993;17:323-32.
112. Watson JG, Jameson B, Powles RL, McElwain TJ, Lawson DN, Judson I, et al. Co-trimoxazole versus nonabsorbable antibiotics in acute leukaemia. Lancet 1982;1(8262):6-9.
113. Weiser B, Lange M, Fialk MA, Singer C, Szatrowski TH, Armstrong D. Prophylactic trimethoprim-sulfamethoxazole during consolidation chemotherapy for acute leukemia: a controlled trial. Annals of Internal Medicine 1981;95:436-8.
114. Winston DJ, Ho WJ, Champlin RE, Karp J, Bartlett J, Finley RS, et al. Norfloxacin for prevention of bacterial infections in granulocytopenic patients. American Journal of Medicine 1987;82(suppl 6B):40-6.
115. Winston DJ, Ho WJ, Nakao SL, Gale RP, Champlin RE. Norfloxacin versus vancomycin/polymyxin for prevention of infections in granulocytopenic patients. American Journal of Medicine 1986;80(5):884-90.
116. Winston DJ, Winston GH, Bruckner DA, Gale RP, Champlin RE. Ofloxacin versus vancomycin/polymyxin for prevention of infections in granulocytopenic patients. American Journal of Medicine 1990;88:36-42.
117. Yamada T, Kazuo T, Nomura T. Prevention of bacterial and fungal infections in acute leukemia patients: a new potent combination of oral norfloxacin and amphotericin b. Internal Medicine 1993;32(9):710-4.
118. Yates JW, Holland JF Yates JW, Holland JF. A controlled study of isolation and endogenous microbial suppression in acute myelocytic leukemia patients. Cancer 1973;32(6):1490-8.
119. Barriga F, Varas M, Potin M, Sapunar F, Rojo H, Martinez A, et al. Efficacy of Vancomycin solution to prevent bacteraemia associated with an indwelling central venous catheter in neutropenic and non-neutropenic cancer patients. Medical and Pediatric Oncology 1997;28:196-200.
120. Bunn, PA. Editorial comments on 'Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III. study'. Annals of Oncology 2001;12(10):1339-40.
121. Capdevila J, Pahissa A. Infection prophylaxis in neutropenic patients [Profilaxis de las infecciones en los pacientes neutropenicos]. Enfermedades Infecciosas y Microbiologica Clininica 1997;15(10):544-51.
122. Corrado ML, Struble WE, Hesney M. The tolerability profile of prophylactic norfloxacin in neutropenic patients. European Journal of Cancer and Clinical Oncology 1988;24 Suppl 1:29-33.
123. Craig M, Cumpston AD, Hobbs GR, Devetten MP, Sarwari AR, Ericson SG. The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit. Bone Marrow Transplantation 2007;39(8):477-82.
124. Cruciani M. Antibacterial prophylaxis. International Journal of Antimicrobial Agents 2000;16(2):123-5.
125. Davis C. The antiviral prophylaxis of post-transplant lymphoproliferative disorder. Springer Seminars in Immunopathology 1998;20(3-4):437-53.
126. Del Favero A, Martino P, Bucaneve G, Micozzi A, D'Antonio D, Minetti B, et al. [Prophylaxis using quinolones in neutropenic patients. Preliminary results of a cooperative study by the Grupo Italiano Malattie Ematologiche maligne dell'adulto (GIMEMEA)]. Haematologica 1989;74 Suppl:278-86.
127. Del Favero A, Menichetti F. The new fluorinated quinolones for antimicrobial prophylaxis in neutropenic cancer patients. European Journal of Cancer 1993;29A Suppl 1:2-6.
128. Delarive P, Baumgartner JD. Evaluation of antibiotic prophylaxis in neutropenic patients with hematologic malignancies [Evaluation de la prophylaxie antibiotique chez les patients neutropeniques avec hemopathie maligne]. Schweizerisce Medizinische Wochenschrift 2000;130(48):1837-44.
129. Donnelly JP. Is there a rationale for the use of antimicrobial prophylaxis in neutropenic patients?. Journal of Internal Medicine Suppl 1997;740:79-88.
130. Ekert H, Jurk IK, Waters KD, Tiedemann K. Prophylactic co-trimoxazole and lactobacilli preparation in neutropenic patients. Medical & Pediatric Oncology 1980;8:47-51.
131. Engervall P, Bjorkholm M. Infections in neutropenic patients II: Management. Medical Oncology 1996;13(1):63-9.
132. Engervall P, Bjorkholm M. Ofloxacin versus co-trimoxazole in prevention of infections in children with neutropenia after cytotoxic chemotherapy. (Short communication). Anti-infective Drugs and Chemotherapy 1996;14(2):105-7.
133. EORTC - Gnotobiotic Project Group. A prospective cooperative study of antimicrobial decontamination in granulocytopenic patients. Comparison of two different methods. Infection 1982;10(3):131-8.
134. Fernndez-Aviles F, Rovira M, Martnez C, Rosiol L, Gallego C, Hernando A, et al. A comparison of the efficacy prophylactic ceftriaxone in patients managed at home after autologous stem cell transplantation using either BEAM or melphalan conditioning: A single-centre experience. Bone Marrow Transplantation 2010;Conference Publication. 45:S394-395.
135. Figueredo AT, Hryniuk WM, Strautmanis I, Frank G, Rendell S. Co-trimoxazole prophylaxis during high-dose chemotherapy of small-cell lung cancer. Journal of Clinical Oncology 1985;3:54-64.
136. Franpton JE, Faulds D. Filgrastim. A reappraisal of pharmacoeconomic considerations in the prophylaxis and treatment of chemotherapy-induced neutropenia. Pharmacoeconomics 1996;9(1):76-96.
137. Garcia G. Immediate vs. delayed imipenem treatment in cancer patients with profound neutropenia induced by high-dose chemotherapy: Results of a randomised study. Revista Espanola de Quimioterapia 2000;15(3):257-63.
138. Giamarellou H. Current approach to the management of neutropenia. Journal of Intensive Care Medicine 1995;10(6):283-93.
139. Gilbert C, Meisenberg B, Vredenburgh J, Ross M, Hussein A, Perfect J, Peters WP. Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support. Journal of Clinical Oncology 1994;12(5):1005-11.
140. Guiot HF, van der Meer JW, van Furth R. Selective antimicrobial modulation of human microbial flora: infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria. The Journal of Infectious Diseases 1981;143(5):644-54.
141. Haahr V, Peterslund NA, Moller JK. The influence of antimicrobial prophylaxis on the microbial and clinical findings in patients after autologous bone marrow transplantation. Scandinavian Journal of Infectious Diseases 1997;29(6):623-6.
142. Hallbk H, Lidstrm AK, Pauksens K. Antibacterial prophylaxis reduces the use of broad-spectrum antibiotics in autologous stem cell transplantation. Bone Marrow Transplantation 2010;Conference Publication. 45:S230.
143. Henry SA. Symposium on infectious complications of neoplastic disease (Part II). Chemoprophylaxis of bacterial infections in granulocytopenic patients. [Review]. American Journal of Medicine 1984;76:645-51.
144. Horvathova Z, Spanik S, Sufliarsky J, Mardiak J, Pichna P, Pichnova E. Bacteremia due to methicillin-resistant staphylococci occurs more frequently in neutropenic patients who received antimicrobial prophylaxis and is associated with higher mortality in comparison to methicillin-sensitive bacteriemia. International Journal of Antimicrobial Agents 1998;10(1):55-8.
145. Imrie KR, Prince HM, Couture F, Brandwein JM, Keating A. Effect of antimicrobial prophylaxis on hematopoietic recovery following autologous bone marrow transplantation: ciprofloxacin versus co-trimoxazole. Bone Marrow Transplantation 1995;15:267-70.
146. Karp JE, Dick JD, Angelopulos C, Carache P, Green L, et al. Empiric use of vancomycin during prolonged treatment-induced granulocytopenia. The American Journal of Medicine 1986;81:237-42.
147. Kerr KG. The prophylaxis of bacterial infections in neutropenic patients. Journal of Antimicrobial Chemotherapy 1999;44(5):587-91.
148. Klastersky J. Prevention of infection in neutropenic cancer patients. Current Opinion in Oncology 1996;8(4):270-8.
149. Krupova Y, Novotny J, Sabo A, Mateicka F, Krcmry V Jr. Aetiology, cost of antimicrobial therapy and outcome in neutropenic patients who developed bacteraemia during antimicrobial prophylaxis: a case-control study. International Journal of Antimicrobial Agents 1998;10(4):313-6.
150. Ljungman P, Hagglund H, Bjorkstrand B, Lonnqvist B, Ringden O. Perioperative teicoplanin for prevention of gram-positive infections in neutropenic patients with indwelling central venous catheters: a randomised, controlled study. Supportive Care in Cancer 1997;5:485-8.
151. Lohner D, Debusscher L, Prevost JM, Klastersky J. Comparative randomised study of protected environment plus oral antibiotics versus oral antibiotics alone in neutropenic patients. Cancer Treatment Reports 1979;63:363-8.
152. Maltezou HC, Kafetzis DA, Rolston KVI. Comparison of Vancomycin (VA) Alone or with Norfloxacin (NO) for Antibacterial Prophylaxis in Adult Hematopoietic Stem Cell Transplant (HSCT) Recipients. Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1999 September; San Francisco. 1999:Abstract 734:599.
153. Maltezou HC, Kafetzis DA, Rolston KVI. Bacterial Prophylaxis vs. Nonprophylaxis Policy in Patients (pts) with Hematopoietic Stem Cell Transplants (HSCT). Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1999 September; San Francisco. 1999:Abstract: 735:599.
154. Mantovani G, Ghiani M, Massidda S, Lai P, Mulas C, Massa E, et al. A clinical trial comparing the efficacy of a single b-lactam antibiotic (Metropenem) with a combination of Metropenem plus Teicoplanin plus Netilmicin in the prophylactic and symptomatic treatment of febrile severe neutropenia following chemotherapy for cancer. Supportive Care in Cancer 1998;6 Suppl:315.
155. Marchetti O, Calandra T, Marchetti O. Infections in neutropenic cancer patients. Lancet 2002;359(9308):723-5.
156. Martino R, Subira M, Altes A, Lopez R, Sureda A, Domingo Albos A. Effect of discontinuing prophylaxis with norfloxacin in patients with hematologic malignancies and severe neutropenia. A matched case-control study of the effect on infectious morbidity. Acta Haematologica 1998;99(4):206-11.
157. Maschmeyer G, Daenen S, de Pauw Be, de Vries Hospers HG, Dekker A W, Donnelly JP. Prevention of infection in acute leukemia. [Review]. Hamatologie und Bluttransfusion 1990;33:525-30.
158. May T, Beuscart C, Reynes J, Marchou B, Leclercq P, Lebas FB. Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: A prospective, randomised, controlled clinical trial. Journal of Acquired Immune Deficiency Syndrome 1994;7:457-62.
159. Menichetti F, Felicini R, Bucaneve G, Aversa F, Greco M, Pasqurella C, et al. Norfloxacin prophylaxis for neutropenic patients undergoing bone marrow transplantation. Bone Marrow Transplantation 1989;4:489-92.
160. Mihaylov G, Vasileva N, Ganeva P. Antibacterial prophylaxis and treatment of the patients with febrile neutropenia during hematopoietic stem cell transplantation. Clinical and Transfusion Haematology 2007;43(1-2):3-14.
161. Minenko SV, Dmitrieva NV, Sokolova EN, Zhukov NV, Ptushkin VV. Efficacy of moxifloxacin (Avelox) in prophylaxis of infection in patients with profound neutropenia. Antibiotiki-i-khimioterapiia 2004;49(3):26-31.
162. Patrick CC. Use of fluoroquinolones as prophylactic agents in patients with neutropenia. Pediatric Infectious Disease Journal 1997;16(1):135-9.
163. Persson L, Vikerfors T, Sjoberg L, Engervall P, Tidefelt U. Increased incidence of bacteraemia due to viridans streptococci in an unselected population of patients with acute myeloid leukaemia. Scandinavian Journal of Infectious Diseases 2000;32(6):615-21.
164. Pivkova A, Stojanoski Z, Cevreska L, Siljanovski N, Karanfilski O, Genadieva-Stravic S, et al. Prevention of neutropenic fever during administration of high dose VP-16 plus G-CSF for mobilization of PBSC - the efficiency of prophylactic antibiotic treatment. Haematologica 2005;90 Suppl 2:448.
165. Reuter S, Kern WV, Sigge A, Dhner H, Marre R, Kern P, et al. Impact of fluoroquinolone prophylaxis on reduced infection-related mortality among patients with neutropenia and hematologic malignancies. Clinical Infectious Diseases 2005;40(8):1087-93.
166. Risi GF, Tomascak V. Prevention of infection in the immunocompromised host. American Journal of Infection Control 1998;26(6):594-606.
167. Schaison GS, Decroly FC. Propylaxis, cost and effectiveness of therapy of infections caused by Gram-positive organisms in neutropenic children. Journal of Antimicrobial Chemotherapy 1991;27:Suppl B:61-7.
168. Solano C, Gutierrez A, Martinez F, Gimeno C, Gomez C, Munoz I, Faus F. Prophylaxis of early bacterial infections after autologous peripheral blood stem cell transplantation (PBSCT): a matched-pair study comparing oral fluoroquinolones and intravenous piperacillin-tazobactam. Bone Marrow Transplantation 2005;36(1):59-65.
169. Spanik S, Sufliarsky J, Mardiak J, Sorkovska D, Trupl J, Kunova A. Predictors of mortality in bacteremic cancer patients: retrospective analysis of 64 deaths occurring among 262 bacteremic episodes. Supportive Care in Cancer 1998;6(3):291-4.
170. Takemoto Y, Kanamaru A, Nagai K, Masaoka T, Kitani T, Horiuchi A. Randomized trial of combination antibiotic therapy in patients with hematological disorders. Japanese Journal of Antibiotics 1990;43:63-9.
171. Timmer-Bonte JN, de Boo TM, Smit HJ, Biesma B, Wilschut FA, Cheragwandi SA, et al. Prevention of chemotherapy-induced febrile neutropenia by prophylactic antibiotics plus or minus granulocyte colony-stimulating factor in small-cell lung cancer: a Dutch Randomized Phase III. Study. Journal of Clinical Oncology 2005;23(31):7974-84.
172. Tjan Heijnen VC, Postmus PE, Ardizzoni A. Reply to the article "Editorial comments on 'reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III. study'", by P. A. Bunn Jr (Ann Oncol 2001; 12: 1339-1340). Annals of Oncology 2002;13(3):485-6.
173. Tunkel AR, Sepkowitz KA. Infections caused by viridans streptococci in patients with neutropenia. Clinical Infectious diseases 2002;34(11):1524-9.
174. Van De Leur JJ, Vollaard EJ, Janssen AJ, DofferhoffAS. Concentration of pefloxacin in feces during infection prophylaxis in neutropenic patients. Antimicrobial Agents and Chemotherapy 1995;39:1182-4.
175. Viscoli C, Paesmans M, Sanz M, Castagnola E, Klastersky J, Martino P, International Antimicrobial Therapy Cooperative Group of the, European Organization for Research, and Treatment of Cancer. Association between antifungal prophylaxis and rate of documented bacteraemia in febrile neutropenic cancer patients. Clinical Infectious Diseases 2001;32:1532-7.
176. Viscoli C, Castagnola E. Planned progressive antimicrobial therapy in neutropenic patients. British Journal of Haematology 1998;102(4):879-88.
177. Viscoli C, Castagnola E. "Treatment of febrile neutropenia: what is new?". Current Opinion in Infectious Diseases 2002;15(4):377-82.
178. von Baum H, Sigge A, Bommer M, Kern WV, Marre R, Dohner H, et al. Moxifloxacin prophylaxis in neutropenic patients. Journal of Antimicrobial Chemotherapy 2006;58(4):891-4.
179. von Minckwitz G, Kummel S, du Bois A, Eiermann W, Eidtmann H, Gerber B, et al. Pegfilgrastim +/- ciprofloxacin for primary prophylaxis with TAC (docetaxel/doxorubicin/cyclophosphamide) chemotherapy for breast cancer. Results from the GEPARTRIO study. Annals of Oncology 2008;19(2):292-8.
180. Wade JC, SchimpffSC, Wiernik PH. Antibiotic combination-associated nephrotoxicity in granulocytopenic patients with cancer. Archives of Internal Medicine 1981;141:1789-93.
181. Wilson JM, Guiney DG. Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukemia: isolation of resistant plasmids from strains of Enterobacteriaceae causing bacteraemia. New England Journal of Medicine 1982;306(1):16-20.
182. Zinner SH. Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria. Clinical Infectious Diseases 1999;29(3):490-4.
183. Bodey GP, Buckley M, Sathe YS, Friereich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Annals of Internal Medicine 1966;64(2):328-40.
184. Cherif H, Bjorkholm M, Engervall P, Johansson P, Ljungman P, Hast R, et al. A prospective, randomised study comparing cefepime and imipenem-cilastatin in the empirical treatment of febrile neutropenia in patients treated for haematological malignancies. Scandinavian Journal of Infectious Diseases 2004;36(8):593-600.
185. Cometta A, Calandra T, Bille J, Glauser MP. Escherichia coli resistant to fluoroquinolones in patients with cancer and neutropenia (letter). New England Journal of Medicine 1994;330:1240-1.
186. Cordonnier C, Calandra T, Meunier F. Guidelines from the first European conference on infections in leukaemia: ECIL1. European Journal of Cancer 2007;Suppl 5(2):1-60.
187. Cruciani M, Rampazzo R, Malena M, Lazzarini L, Todeschini G, Messori A, et al. Prophylaxis with fluoroquinolones for bacterial infections in neutropenic patients: a meta-analysis. Clinical Infectious Diseases 1996;23:795-805.
188. Cruciani M, Malena M, Bosco O, Nardi S, Serpelloni G, Mengoli C. Reappraisal with meta-analysis of the addition of gram-positive prophylaxis to fluoroquinolone in neutropenic patients. Journal of Clinical Oncology 2003;21(22):4127-37.
189. de Marie S, van den Broek PJ, Willimze R, van Furth R. Strategy for antibiotic therapy in febrile neutropenic patients on selective antimicrobial decontamination. European Journal of Clinical Microbiology and Infectious diseases 1993;12:897-906.
190. De Pauw BE, Deresinski SC, Feld R, Lane-Allman EF, Donnelly JP. Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. A multicentre randomised trial. The Intercontinental Antimicrobial Study Group. Annals of Internal Medicine 1994;120(10):834-44.
191. Donnelly JP, Maschmeyer G, Daenen S. Selective oral antimicrobial prophylaxis for the prevention of infection in acute leukaemia-ciprofloxacin versus co-trimoxazole plus colistin. European Journal of Cancer 1992;28A:873-8.
192. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
193. Engels E, Lau J, Barza M. Efficacy of quinolone prophylaxis in neutropenic cancer patients: a meta-analysis. Journal of Clinical Oncology 1998;16(3):1179-87.
194. EORTC International Antimicrobial Therapy Cooperative Group. Gram-positive bacteraemia in granulocytopenic cancer patients. European Journal of Cancer 1990;26(5):569-74.
195. Frank DA. Review: Prophylactic use of granulocyte colony-stimulating factor reduces febrile neutropenia and short-term mortality in cancer. ACP J Club 2008;148(1):7.
196. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clinical Infectious Diseases 2011;52(4):e56-e93.
197. Gentry C, Flournoy DJ, Reinert R. Analysis of antimicrobial resistance among gram-negative bacilli and antimicrobial use in intensive care unit patients for 5 years in a Veterans Affairs medical centre. American Journal of Infection Control 2002;30(7):411-6.
198. Giamarellou H, Bassaris HP, Petrikkos G, Busch W, Voulgarelis M, Antoniadou A, et al. Monotherapy with intravenous followed by oral high-dose ciprofloxacin versus combination therapy with ceftazidime plus amikacin as initial empiric therapy for granulocytopenic patients with fever. Antimicrobial Agents and Chemotherapy 2000;44(12):3264-71.
199. Higgins JPT, Green S, editors. Handbook for Systematic Reviews of Interventions 4.2.5 [Updated May 2005]. The Cochrane Library, Issue 3, 2005. Chichester, UK: John Wiley & Sons, Ltd, 2005.
200. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available from www.cochrane-handbook.org.
201. Hughes WT, Kuhn S, Chaudhary S, Feldman S, Verzosa M, Aur RJ, et al. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. New England Journal of Medicine 1977;297:1419-26.
202. Hughes WT, Armstrong D, Bodey GP, Feld R, Mandell GL, Meyers JD, et al. From the Infectious Diseases Society of America: guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Journal of Infectious Diseases 1990;161:381-96.
203. Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandray T, et al. Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clinical Infectious Diseases 2002;34(6):730-51.
204. Imran H, Tleyjeh IM, Arndt CAS, Baddour LM, Erwin PJ, Tsigrelis C, et al. Fluoroquinolone prophylaxis in patients wth neutropenia: a meta-analysis of randomized placebo-controlled trials. European Journal of Clinical Microbiology and Infectious Diseases 2008;27:53-63.
205. Kern Wv, Kurrle E. Ofloxacin versus trimethoprim-sulfamethoxazole for prevention of infection in patients with acute leukemia and granulocytopenia. Infection 1991;19:73-80.
206. Kern WV, Androf E, Oethinger M, Kern P, Hacker J, Marre R. Emergence of fluoroquinolone-resistant Escherichia coli at a cancer centre. Antimicrobial Agents and Chemotherapy 1994;38:681-7.
207. Kerr KG. The prophylaxis of bacterial infections in neutropenic patients. Journal of Antimicrobial Chemotherapy 1999;44(5):587-91.
208. Kuderer NM, Dale DC, Crawford J, Lyman GH. Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. Journal of Clinical Oncology 2007;25(21):3158-67.
209. Lucas KG, Brown AE, Armstrong D. The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteraemia and complications of sepsis. Cancer 1996;77(4):791-8.
210. Massey E, Paulus U, Doree C, Stanworth S. Granulocyte transfusions for preventing infections in patients with neutropenia or neutrophil dysfunction. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD005341]
211. Oppenheim BA, Hartley JW, Lee W, Burnie JP. Outbreak of coagulase negative staphylococci highly resistant to ciprofloxacin in a leukemia unit. British Medical Journal 1989;299:294-7.
212. Patrick CC. Use of fluoroquinolones as prophylactic agents in patients with neutropenia. Pediatric Infectious Disease 1997;16:135-9.
213. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
214. Roblot F, Imbert S, Godet C, Kauffmann C, Ragot S, Le Moal G, et al. Risk factors analysis for Pneumocystis jiroveci pneumonia (PCP) in patients with haematological malignancies and pneumonia. Scandinavian Journal of Infectious Diseases 2004;36:848-54.
215. Rolston KV, Berkey P, Bodey GP, Anaissie EJ, Khardori NM, Joshi JH, et al. A comparison of imipenem to ceftazidime with or without amikacin as empiric therapy in febrile neutropenic patients. Archives of Internal Medicine 1992;152:283-91.
216. Rotstein C, Mandell LA, Goldberg N. Fluoroquinolone prophylaxis for profoundly neutropenic cancer patients: a meta-analysis. Current Oncology 1997;4 suppl 2:2-7.
217. SchimpffSC. Empiric Antibiotic therapy for granulocytopenic cancer patients. American Journal of Medicine 1986;80(Suppl 5c):13-20.
218. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment in controlled trials. JAMA 1995;273:408-12.
219. van de Wetering MD, Weggelaar N, Offringa M, Caron HN, Kuijpers TW. Granulocyte transfusions in neutropaenic children: a systematic review of the literature. European Journal of Cancer 2007;43(14):2082-92.
220. Verhoef J. Prevention of infections in neutropenic patients. Clinical Infectious Diseases 1993;17 Suppl 2:359-67.
221. Walsh T, Karp J, Hathorn JW, Pizzo PA. Prevention of bacterial infections in neutropenic patients. Bailliere's Clinical Infectious Diseases 1994;1:469-98.
222. Worth LJ, Dooley MJ, Seymour JF, Mileshkin L, Slavin MA, Thursky KA. An analysis of the utilisation of chemoprophylaxis against Pneumocystis jirovecii pneumonia in patients with malignancy receiving corticosteroid therapy at a cancer hospital. British Journal of Cancer 2005;92:867-72.
223. Gafter-Gvili A, Fraser A, Paul M, Leibovici L. Meta-Analysis: Antibiotic prophylaxis reduces mortality in neutropenic patients. Annals of Internal Medicine 2005;142(12 pt 1):979-95.
224. Gafter-Gvili A, Fraser A, Paul M, van de Wetering MD, Kremer LMC, Leibovici L. Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy. Cochrane Database of Systematic Reviews 2005, Issue 4. [DOI: 10.1002/14651858.CD004386]
225. van de Wetering MD, van de Witte MA, Kremer LCM, Offringa M, Scholten RJPM, Caron HN. Efficacy of oral prophylactic antibiotics in neutropenic afebrile oncology patients: A systematic review of randomised controlled trials. European Journal of Cancer 2005;41:1372-82.