Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia

Human Molecular Genetics

Volumn 22, Issue 16, 2013, Pages 3381-3393

  Reiner, Alexander P ^a   Hartiala, Jaana ^c   Zeller, Tanja ^d   Bis, Joshua C ^b   Dupuis, Josée ^e,f   Fornage, Myriam ^g   Baumert, Jens ^h   Kleber, Marcus E ^i,j   Wild, Philipp S ^k   Baldus, Stephan ^d   Bielinski, Suzette J ^l   Fontes, João D ^e,f   Illig, Thomas ^h,m   Keating, Brendan J ^n,o   Lange, Leslie A ^p   Ojeda, Francisco ^d   Müller Nurasyid, Martina ^h,q,r   Munzel, Thomas F ^k   Psaty, Bruce M ^a,b,s   Rice, Kenneth ^a   Rotter, Jerome I ^t   Schnabel, Renate B ^d   Tang, W H Wilson ^u   Thorand, Barbara ^h   Erdmann, Jeanette ^v   Jacobs Jr , David R ^w   Wilson, James G ^x   Koenig, Wolfgang ^y   Tracy, Russell P ^z   Blankenberg, Stefan ^d   März, Winfried ^j,aa   Gross, Myron D ^ab   Benjamin, Emelia J ^e,f   Hazen, Stanley L ^u   Allayee, Hooman ^c   more..

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY HEART CENTER HAMBURG   (Germany)

^e FRAMINGHAM HEART STUDY   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ LURIC Study Nonprofit LLC   (Germany)

^j UNIVERSITY OF HEIDELBERG   (Germany)

^k JOHANNES GUTENBERG UNIVERSITY   (Germany)

^l MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^m Hannover Unified Biobank   (Germany)

ⁿ CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^o UNIVERSITY OF PENNSYLVANIA   (United States)

^p UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^q LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^r UNIVERSITY OF MUNICH   (Germany)

^s CENTER FOR HEALTH STUDIES   (United States)

^t Medical Genetics Research Institute   (United States)

^u LERNER RESEARCH INSTITUTE   (United States)

^v UNIVERSITY OF LÜBECK   (Germany)

^w UNIVERSITY OF MINNESOTA   (United States)

^x UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^y UNIVERSITY OF ULM   (Germany)

^z UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^aa SYNLAB ACADEMY   (Germany)

^ab UNIVERSITY OF MINNESOTA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT FACTOR H; MYELOPEROXIDASE;

AFRICAN AMERICAN; ARTICLE; CARDIOVASCULAR RISK; CHROMOSOME 17Q; CHROMOSOME 1Q; CORONARY ARTERY DISEASE; ENZYME BLOOD LEVEL; EUROPEAN AMERICAN; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENOME ANALYSIS; HEREDITY; HUMAN; META ANALYSIS; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFRICAN AMERICANS; AGED; CASE-CONTROL STUDIES; COMPLEMENT FACTOR H; CORONARY ARTERY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PEROXIDASE; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84881241528     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt189     Document Type: Article

References (50)

1. Arnhold, J. and Flemmig, J. (2010) Human myeloperoxidase in innate and acquired immunity. Arch. Biochem. Biophys., 500, 92-106.
2. Nicholls, S.J. and Hazen, S.L. (2005) Myeloperoxidase and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol., 25, 1102-1111.
3. Nicholls, S.J., Zheng, L. and Hazen, S.L. (2005) Formation of dysfunctional high-density lipoprotein by myeloperoxidase. Trends Cardiovasc. Med., 15, 212-219.
4. Nicholls, S.J. and Hazen, S.L. (2009) Myeloperoxidase, modified lipoproteins and atherogenesis. J. Lipid Res., 50(Suppl), S346-351.
5. Brennan, M.L., Penn, M.S., Van Lente, F., Nambi, V., Shishehbor, M.H., Aviles, R.J., Goormastic, M., Pepoy, M.L., McErlean, E.S., Topol, E.J. et al. (2003) Prognostic value of myeloperoxidase in patients with chest pain. N. Engl. J. Med., 349, 1595-1604.
6. Baldus, S., Heeschen, C., Meinertz, T., Zeiher, A.M., Eiserich, J.P., Munzel, T., Simoons, M.L. and Hamm, C.W. (2003) Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation, 108, 1440-1445.
7. Tang, W.H., Tong, W., Troughton, R.W., Martin, M.G., Shrestha, K., Borowski, A., Jasper, S., Hazen, S.L. and Klein, A.L. (2007) Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure. J. Am. Coll. Cardiol., 49, 2364-2370.
8. Karakas, M. and Koenig, W. (2012) Myeloperoxidase production by macrophage and risk of atherosclerosis. Curr. Atheroscler. Rep., 14, 277-283.
9. Schnabel, R.B., Lunetta, K.L., Larson, M.G., Dupuis, J., Lipinska, I., Rong, J., Chen, M.H., Zhao, Z., Yamamoto, J.F., Meigs, J.B. et al. (2009) The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations. Circ. Cardiovasc. Genet., 2, 229-237.
10. Walker, A.E., Seibert, S.M., Donato, A.J., Pierce, G.L. and Seals, D.R. (2010) Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension, 55, 363-369.
11. Tang, W.H., Wu, Y., Nicholls, S.J. and Hazen, S.L. (2011) Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease. Clin. Chem., 57, 33-39.
12. Hoy, A., Tregouet, D., Leininger-Muller, B., Poirier, O., Maurice, M., Sass, C., Siest, G., Tiret, L. and Visvikis, S. (2001) Serum myeloperoxidase concentration in a healthy population: biological variations, familial resemblance and new genetic polymorphisms. Eur. J. Hum. Genet., 9, 780-786.
13. Romano, M., Dri, P., Dadalt, L., Patriarca, P. and Baralle, F.E. (1997) Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. Blood, 90, 4126-4134.
14. Marchetti, C., Patriarca, P., Solero, G.P., Baralle, F.E. and Romano, M. (2004) Genetic characterization of myeloperoxidase deficiency in Italy. Hum. Mutat., 23, 496-505.
15. Kutter, D., Devaquet, P., Vanderstocken, G., Paulus, J.M., Marchal, V. and Gothot, A. (2000) Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit?. Acta Haematol., 104, 10-15.
16. Nikpoor, B., Turecki, G., Fournier, C., Theroux, P. and Rouleau, G.A. (2001) A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians. Am. Heart J., 142, 336-339.
17. Wainstein, R.V., Wainstein, M.V., Ribeiro, J.P., Dornelles, L.V., Tozzati, P., Ashton-Prolla, P., Ewald, I.P., Vietta, G. and Polanczyk, C.A. (2010) Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. Clin. Biochem., 43, 57-62.
18. Ergen, A., Isbir, S., Timirci, O., Tekeli, A. and Isbir, T. (2011) Effects of myeloperoxidase -463 G/A gene polymorphism and plasma levels on coronary artery disease. Mol. Biol. Rep., 38, 887-891.
19. Asselbergs, F.W., Reynolds, W.F., Cohen-Tervaert, J.W., Jessurun, G.A. and Tio, R.A. (2004) Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease. Am.J. Med., 116, 429-430.
20. Zeller, T., Wild, P., Szymczak, S., Rotival, M., Schillert, A., Castagne, R., Maouche, S., Germain, M., Lackner, K., Rossmann, H. et al. (2010) Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS One, 5, e10693.
21. Arakawa, S., Takahashi, A., Ashikawa, K., Hosono, N., Aoi, T., Yasuda, M., Oshima, Y., Yoshida, S., Enaida, H., Tsuchihashi, T. et al. (2011) Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Nat. Genet., 43, 1001-1004.
22. Klein, R.J., Zeiss, C., Chew, E.Y., Tsai, J.Y., Sackler, R.S., Haynes, C., Henning, A.K., SanGiovanni, J.P., Mane, S.M., Mayne, S.T. et al. (2005) Complement factor H polymorphism in age-related macular degeneration. Science, 308, 385-389.
23. Neale, B.M., Fagerness, J., Reynolds, R., Sobrin, L., Parker, M., Raychaudhuri, S., Tan, P.L., Oh, E.C., Merriam, J.E., Souied, E. et al. (2010) Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc. Natl Acad. Sci. USA, 107, 7395-7400.
24. Chen, W., Stambolian, D., Edwards, A.O., Branham, K.E., Othman, M., Jakobsdottir, J., Tosakulwong, N., Pericak-Vance, M.A., Campochiaro, P.A., Klein, M.L. et al. (2010) Genetic variants nearTIMP3and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc. Natl Acad. Sci. USA, 107, 7401-7406.
25. Kopplin, L.J., Igo, R.P. Jr, Wang, Y., Sivakumaran, T.A., Hagstrom, S.A., Peachey, N.S., Francis, P.J., Klein, M.L., SanGiovanni, J.P., Chew, E.Y. et al. (2010) Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun., 11, 609-621.
26. Davila, S., Wright, V.J., Khor, C.C., Sim, K.S., Binder, A., Breunis, W.B., Inwald, D., Nadel, S., Betts, H., Carrol, E.D. et al. (2010) Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat. Genet., 42, 772-776.
27. Gharavi, A.G., Kiryluk, K., Choi, M., Li, Y., Hou, P., Xie, J., Sanna-Cherchi, S., Men, C.J., Julian, B.A., Wyatt, R.J. et al. (2011) Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat. Genet., 43, 321-327.
28. Caprioli, J., Noris, M., Brioschi, S., Pianetti, G., Castelletti, F., Bettinaglio, P., Mele, C., Bresin, E., Cassis, L., Gamba, S. et al. (2006) Genetics of HUS: the impact ofMCP,CFH, and IF mutations on clinical presentation, response to treatment and outcome. Blood, 108, 1267-1279.
29. Abrera-Abeleda, M.A., Nishimura, C., Smith, J.L., Sethi, S., McRae, J.L., Murphy, B.F., Silvestri, G., Skerka, C., Jozsi, M., Zipfel, P.F. et al. (2006) Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). J. Med. Genet., 43, 582-589.
30. Zhao, J., Wu, H., Khosravi, M., Cui, H., Qian, X., Kelly, J.A., Kaufman, K.M., Langefeld, C.D., Williams, A.H., Comeau, M.E. et al. (2011) Association of genetic variants in complement factorH and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet, 7, e1002079.
31. Goldstein, I.M., Roos, D., Kaplan, H.B. and Weissmann, G. (1975) Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis. J. Clin. Invest., 56, 1155-1163.
32. Baehner, R.L. (1975) Microbe ingestion and killing by neutrophils: normal mechanisms and abnormalities. Clin. Haematol., 4, 609-633.
33. Boxer, L.A. and Smolen, J.E. (1988) Neutrophil granule constituents and their release in health and disease. Hematol. Oncol. Clin. North Am., 2, 101-134.
34. Yu, Y., Bhangale, T.R., Fagerness, J., Ripke, S., Thorleifsson, G., Tan, P.L., Souied, E.H., Richardson, A.J., Merriam, J.E., Buitendijk, G.H. et al. (2011) Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum. Mol. Genet., 20, 3699-3709.
35. Tortajada, A., Montes, T., Martinez-Barricarte, R., Morgan, B.P., Harris, C.L. and de Cordoba, S.R. (2009) The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Hum. Mol. Genet., 18, 3452-3461.
36. Schnabel, R.B., Baumert, J., Barbalic, M., Dupuis, J., Ellinor, P.T., Durda, P., Dehghan, A., Bis, J.C., Illig, T., Morrison, A.C. et al. (2010) Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators. Blood, 115, 5289-5299.
37. Weismann, D., Hartvigsen, K., Lauer, N., Bennett, K.L., Scholl, H.P., Charbel Issa, P., Cano, M., Brandstatter, H., Tsimikas, S., Skerka, C. et al. (2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature, 478, 76-81.
38. Oldenborg, P.A., Gresham, H.D. and Lindberg, F.P. (2001) CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. J. Exp. Med., 193, 855-862.
39. Piccio, L., Vermi, W., Boles, K.S., Fuchs, A., Strader, C.A., Facchetti, F., Cella, M. and Colonna, M. (2005) Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood, 105, 2421-2427.
40. Hadley, T.J. and Peiper, S.C. (1997) From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen. Blood, 89, 3077-3091.
41. Reich, D., Nalls, M.A., Kao, W.H., Akylbekova, E.L., Tandon, A., Patterson, N., Mullikin, J., Hsueh, W.C., Cheng, C.Y., Coresh, J. et al. (2009) Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet, 5, e1000360.
42. Reynolds, W.F., Chang, E., Douer, D., Ball, E.D. and Kanda, V. (1997) An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia. Blood, 90, 2730-2737.
43. Willer, C.J., Sanna, S., Jackson, A.U., Scuteri, A., Bonnycastle, L.L., Clarke, R., Heath, S.C., Timpson, N.J., Najjar, S.S., Stringham, H.M. et al. (2008) Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat. Genet., 40, 161-169.
44. Zheng, L., Nukuna, B., Brennan, M.L., Sun, M., Goormastic, M., Settle, M., Schmitt, D., Fu, X., Thomson, L., Fox, P.L. et al. (2004) Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J. Clin. Invest., 114, 529-541.
45. Wu, Z., Wagner, M.A., Zheng, L., Parks, J.S., Shy, J.M. III, Smith, J.D., Gogonea, V. and Hazen, S.L. (2007) The refined structure of nascent HDL reveals a key functionaldomain for particle maturation and dysfunction. Nat. Struct. Mol. Biol., 14, 861-868.
46. Undurti, A., Huang, Y., Lupica, J.A., Smith, J.D., DiDonato, J.A. and Hazen, S.L. (2009) Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. J. Biol. Chem., 284, 30825-30835.
47. Musunuru, K., Lettre, G., Young, T., Farlow, D.N., Pirruccello, J.P., Ejebe, K.G., Keating, B.J., Yang, Q., Chen, M.H., Lapchyk, N. et al. (2010) Candidate gene association resource (CARe): design, methods, and proof of concept. Circ. Cardiovasc. Genet., 3, 267-275.
48. Keating, B.J., Tischfield, S., Murray, S.S., Bhangale, T., Price, T.S., Glessner, J.T., Galver, L., Barrett, J.C., Grant, S.F., Farlow, D.N. et al. (2008) Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One, 3, e3583.
49. Willer, C.J., Li, Y. and Abecasis, G.R. (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics, 26, 2190-2191.
50. Schunkert, H., Konig, I.R., Kathiresan, S., Reilly, M.P., Assimes, T.L., Holm, H., Preuss, M., Stewart, A.F., Barbalic, M., Gieger, C. et al. (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet., 43, 333-338.