Design of a flow-controlled asymmetric droplet splitter using computational fluid dynamics

Microfluidics and Nanofluidics

Volumn 15, Issue 2, 2013, Pages 243-252

  Verbruggen, Bert ^a   Tóth, Tamara ^a   Atalay, Yegermal Tesfaw ^a   Ceyssens, Frederik ^a   Verboven, Pieter ^a   Puers, Robert ^a   Nicolai, Bart ^a   Lammertyn, Jeroen ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Asymmetric splitting; Computational fluid dynamics; Droplets in micro channels; Segmented flow microfluidics

Indexed keywords

ASYMMETRIC SPLITTING; COMPUTATIONAL FLUID DYNAMICS MODELS; DROPLET FORMATION; MICRO-FLUIDIC DEVICES; SEGMENTED FLOW; SIMULATED RESULTS; SPLITTING RATIO; TRIAL-AND-ERROR APPROACH;

COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; DROPS; MAGNETIC SEPARATION;

DESIGN;

EID: 84881240807     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-013-1139-3     Document Type: Article

References (36)

1. Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using "flow focusing" in microchannels. Appl Phys Lett 82:364. doi: 10.1063/1.1537519
2. Atalay YT, Verboven P, Vermeir S et al (2008) Design optimization of an enzymatic assay in an electrokinetically-driven microfluidic device. Microfluid Nanofluid 5:837-849. doi: 10.1007/s10404-008-0291-7
3. Atalay YT, Witters D, Vermeir S et al (2009) Design and optimization of a double-enzyme glucose assay in microfluidic lab-on-a-chip. Biomicrofluidics 3:44103. doi: 10.1063/1.3250304
4. Brackbill J, Kothe D, Zemach C (1992) A continuum method for modeling surface tension. J Comput Phys 335354:335-354. doi: 10.1016/0021-9991(92)90240-Y
5. Christopher GF, Bergstein J, End NB et al (2009) Coalescence and splitting of confined droplets at microfluidic junctions. Lab Chip 9:1102-1109. doi: 10.1039/b813062k
6. De Lózar A, Juel A, Hazel AL (2008) The steady propagation of an air finger into a rectangular tube. J Fluid Mech 614:173. doi: 10.1017/S0022112008003455
7. De Menech M, Garstecki P, Jousse F, Stone HA (2008) Transition from squeezing to dripping in a microfluidic T-shaped junction. J Fluid Mech 595:141-161. doi: 10.1017/S002211200700910X
8. Dreyfus R, Tabeling P, Willaime H (2003) Ordered and disordered patterns in two-phase flows in microchannels. Phys Rev Lett 90:1-4. doi: 10.1103/PhysRevLett.90.144505
9. Duffy DC, McDonald JC, Schueller OJ, Whitesides GM (1998) Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal Chem 70:4974-4984. doi: 10.1021/ac980656z (Pubitemid 28553167)
10. Garstecki P, Fuerstman MJ, Stone HA, Whitesides GM (2006) Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up. Lab Chip 6:437-446 (Pubitemid 43327570)
11. Grodrian A, Metze J, Henkel T et al (2004) Segmented flow generation by chip reactors for highly parallelized cell cultivation. Biosens Bioelectron 19:1421-1428. doi: 10.1016/j.bios.2003.12.021 (Pubitemid 38456914)
12. Günther A, Jensen KF (2006) Multiphase microfluidics: from flow characteristics to chemical and materials synthesis. Lab Chip 6:1487-1503. doi: 10.1039/b609851g (Pubitemid 46100744)
13. Hirt C, Nichols B (1981) Volume of fluid (VOF) method for the dynamics of free boundaries. J Comput Phys 39:201-225. doi: 10.1016/0021-9991(81)90145-5
14. Holtze C, Rowat AC, Agresti JJ et al (2008) Biocompatible surfactants for water-in-fluorocarbon emulsions. Lab Chip 8:1632-1639. doi: 10.1039/b806706f
15. Huebner A, Srisa-Art M, Holt DJ et al (2007) Quantitative detection of protein expression in single cells using droplet microfluidics. Chem Commun 1218-1220. doi: 10.1039/b618570c (Pubitemid 46412142)
16. Huebner A, Olguin LF, Bratton D et al (2008) Development of quantitative cell-based enzyme assays in microdroplets. Anal Chem 80:3890-3896. doi: 10.1021/ac800338z (Pubitemid 351705897)
17. Huebner A, Bratton D, Whyte G et al (2009) Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab Chip 9:692-698. doi: 10.1039/b813709a
18. Kolb WB, Cerro RL (1993) The motion of long bubbles in tubes of square cross section. Phys Fluids A Fluid Dyn 5:1549. doi: 10.1063/1.858832
19. Link DR, Anna SL, Weitz DA, Stone HA (2004) Geometrically mediated breakup of drops in microfluidic devices. Phys Rev Lett 92:054503. doi: 10.1103/PhysRevLett.92.054503
20. Liu H, Zhang Y (2011) Droplet formation in microfluidic cross-junctions. Phys Fluids 23:082101. doi: 10.1063/1.3615643
21. Lombardi D, Dittrich PS (2011) Droplet microfluidics with magnetic beads: a new tool to investigate drug-protein interactions. Anal Bioanal Chem 399:347-352. doi: 10.1007/s00216-010-4302-7
22. Nie J, Kennedy RT (2010) Sampling from nanoliter plugs via asymmetrical splitting of segmented flow. Anal Chem 82:7852-7856. doi: 10.1021/ac101723x
23. Nightingale AM, De Mello JC (2010) Microscale synthesis of quantum dots. J Mater Chem 20:8454. doi: 10.1039/c0jm01221a
24. Nisisako T, Torii T (2008) Microfluidic large-scale integration on a chip for mass production of monodisperse droplets and particles. Lab Chip 8:287-293. doi: 10.1039/b713141k (Pubitemid 351191407)
25. Niu X, Gulati S, Edel JB, DeMello AJ (2008) Pillar-induced droplet merging in microfluidic circuits. Lab Chip 8:1837-1841. doi: 10.1039/b813325e
26. Olbricht WL (1996) Pore-scale prototypes of multiphase flow in porous media. Annu Rev Fluid Mech 28:187-213. doi: 10.1146/annurev.fl.28.010196.001155 (Pubitemid 126468750)
27. Pan X, Zeng S, Zhang Q et al (2011) Sequential microfluidic droplet processing for rapid DNA extraction. Electrophoresis 1-7. doi: 10.1002/elps.201100078
28. Pekin D, Skhiri Y, Baret J-C et al (2011) Quantitative and sensitive detection of rare mutations using droplet-based microfluidics. Lab Chip 11:2156-2166. doi: 10.1039/c1lc20128j
29. Sivasamy J, Wong T-N, Nguyen N-T, Kao LT-H (2011) An investigation on the mechanism of droplet formation in a microfluidic T-junction. Microfluid Nanofluid 11:1-10. doi: 10.1007/s10404-011-0767-8
30. Song H, Ismagilov RF (2003) Millisecond kinetics on a microfluidic chip using nanoliters of reagents. J Am Chem Soc 125:14613-14619. doi: 10.1021/ja0354566 (Pubitemid 37452397)
31. Song H, Tice JD, Ismagilov RF (2003) A microfluidic system for controlling reaction networks in time. Angew Chem 115:792-796. doi: 10.1002/ange.200390172
32. Srisa-Art M, deMello AJ, Edel JB (2010) High-efficiency single-molecule detection within trapped aqueous microdroplets. J phys chem B 114:15766-15772. doi: 10.1021/jp105749t
33. Thorsen T, Roberts R, Arnold F, Quake SR (2001) Dynamic pattern formation in a vesicle-generating microfluidic device. Phys Rev Lett 86:4163-4166. doi: 10.1103/PhysRevLett.86.4163 (Pubitemid 32443957)
34. Whitesides GM (2006) The origins and the future of microfluidics. Nature 442:368-373. doi: 10.1038/nature05058 (Pubitemid 44264779)
35. Yamada M, Doi S, Maenaka H et al (2008) Hydrodynamic control of droplet division in bifurcating microchannel and its application to particle synthesis. J Colloid Interface Sci 321:401-407. doi: 10.1016/j.jcis.2008.01.036 (Pubitemid 351474517)
36. Zheng B, Tice JD, Roach LS, Ismagilov RF (2004) A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction. Angew Chem 43:2508-2511. doi: 10.1002/anie.200453974 (Pubitemid 39257710)