The Basolateral Amygdala is critical for learning about neutral stimuli in the presence of danger, and the perirhinal cortex is critical in the absence of danger

Journal of Neuroscience

Volumn 33, Issue 32, 2013, Pages 13112-13125

  Holmes, Nathan M ^a   Parkes, Shauna L ^b   Killcross, A Simon ^a   Westbrook, R Frederick ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IFENPRODIL; MUSCIMOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSOCIATION; AUDITORY STIMULATION; BASOLATERAL AMYGDALA; CONDITIONING; CONTROLLED STUDY; FEAR; HISTOLOGY; MALE; NERVE CELL NETWORK; NERVE POTENTIAL; NONHUMAN; PERIRHINAL CORTEX; PRIORITY JOURNAL; RAT; REINFORCEMENT; TASK PERFORMANCE; VISUAL STIMULATION;

ACOUSTIC STIMULATION; AMYGDALA; ANIMALS; ASSOCIATION LEARNING; CONDITIONING, CLASSICAL; ENVIRONMENT; EXCITATORY AMINO ACID ANTAGONISTS; EXTINCTION, PSYCHOLOGICAL; FEAR; FREEZING REACTION, CATALEPTIC; GABA-A RECEPTOR AGONISTS; MALE; MUSCIMOL; PHOTIC STIMULATION; PIPERIDINES; PREFRONTAL CORTEX; RATS; RATS, WISTAR;

EID: 84881192882     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1998-13.2013     Document Type: Article

References (31)

1. Adolphs R, Denburg NL, Tranel D (2001) The amygdala's role in long-term declarative memory for gist and detail. Behav Neurosci 115:983-992. CrossRef Medline
2. Bauer EP, Paz R, Paré D (2007) Gamma oscillations coordinate amygdalorhinal interactions during learning. J Neurosci 27:9369-9379. CrossRef Medline
3. Buckley TC, Blanchard EB, Neill WT (2000) Information processing and PTSD: a review of the empirical literature. Clin Psychol Rev 20:1041-1065. CrossRef Medline
4. Coppock WJ (1958) Pre-extinction in sensory preconditioning. J Exp Psychol 55:213-219. CrossRef Medline
5. Doron NN, Ledoux JE (2000) Cells in the posterior thalamus project to both amygdala and temporal cortex: a quantitative retrograde double-labeling study in the rat. J Comp Neurol 425:257-274. CrossRef Medline
6. Doyère V, Schafe GE, Sigurdsson T, LeDoux JE (2003) Long-term potentiation in freely moving rats reveals asymmetries in thalamic and cortical inputs to the lateral amygdala. Eur J Neurosci 17:2703-2715. CrossRef Medline
7. Fanselow MS (1980) Conditioned and unconditional components of postshock freezing. Pavlov J Biol Sci 15:177-182. Medline
8. Gewirtz JC, Davis M (1997) Second-order fear conditioning prevented by blocking NMDA receptors in amygdala. Nature 388:471-474. CrossRef Medline
9. Goodman J, Leong KC, Packard MG (2012) Emotional modulation of multiple memory systems: implications for the neurobiology of posttraumatic stress disorder. Rev Neurosci 23:627-643. CrossRef Medline
10. Hays WL (1963) Statistics for psychologists. New York: Holt, Rinehart and Winston.
11. Herry C, Ciocchi S, Senn V, Demmou L, Müller C, Lüthia (2008) Switching on and off fear by distinct neuronal circuits. Nature 454:600-606. CrossRef Medline
12. Isaac CL, Cushway D, Jones GV (2006) Is posttraumatic stress disorder associated with specific deficits in episodic memory? Clin Psychol Rev 26: 939-955. CrossRef Medline
13. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R (2012) Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci 15:1613-1620. CrossRef Medline
14. LeDoux J (2003) The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 23:727-738. CrossRef Medline
15. LeDoux J (2007) The amygdala. Curr Biol 17:R868-R874. CrossRef Medline
16. Li XF, Stutzmann GE, LeDoux JE (1996) Convergent but temporally separated inputs to lateral amygdala neurons from the auditory thalamus and auditory cortex use different postsynaptic receptors: in vivo intracellular and extracellular recordings in fear conditioning pathways. Learn Mem 3:229-242. CrossRef Medline
17. Nicholson DA, Freeman JH Jr (2000) Lesions of the perirhinal cortex impair sensory preconditioning in rats. Behav Brain Res 112:69-75. CrossRef Medline
18. Parkes SL, Westbrook RF (2010) The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli. J Neurosci 30:12608-12618. CrossRef Medline
19. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates, Ed 3. San Diego: Academic.
20. Paz R, Pelletier JG, Bauer EP, Paré D (2006) Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions. Nat Neurosci 9:1321-1329. CrossRef Medline
21. Paz R, Bauer EP, Paré D (2009) Measuring correlations and interactions among four simultaneously recorded brain regions during learning. J Neurophysiol 101:2507-2515. CrossRef Medline
22. Pitkanen A, Pikkarainen M, Nurminen N, Ylinen A (2000) Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann N Y Acad Sci 911:369-391. CrossRef Medline
23. Rodrigues SM, Schafe GE, LeDoux JE (2001) Intra-amygdala blockade of the NR2B subunit of theNMDAreceptor disrupts the acquisition but not the expression of fear conditioning. J Neurosci 21:6889-6896. Medline
24. Shi CJ, Cassell MD (1999) Perirhinal cortex projections to the amygdaloidcomplex and hippocampal formation in the rat. J Comp Neurol 406: 299-328. CrossRef Medline
25. Sigurosson T, Cain CK, Doyere V, LeDoux JE (2010) Asymmetries in longterm and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo. The Eur J Neurosci 31:250-262. CrossRef
26. Sotres-Bayon F, Bush DE, LeDoux JE (2007) Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 32:1929-1940. CrossRef Medline
27. Weber DL (2008) Information processing bias in post-traumatic stress disorder. Open Neuroimag J 2:29-51. CrossRef Medline
28. Weisskopf MG, LeDoux JE (1999) Distinct populations ofNMDAreceptors at subcortical and cortical inputs to principal cells of the lateral amygdala. J Neurophysiol 81:930-934. Medline
29. Wilensky AE, Schafe GE, LeDoux JE (1999) Functional inactivation of the amygdala before but not after auditory fear conditioning prevents memory formation. J Neurosci 19:RC48. Medline
30. Yaniv D, Schafe GE, LeDoux JE, Richter-Levin G (2000) Perirhinal cortex and thalamic stimulation induces LTP in different areas of the amygdala. Ann N Y Acad Sci 911:474-476. CrossRef Medline
31. Yaniv D, Schafe GE, LeDoux JE, Richter-Levin G (2001) A gradient of plasticity in the amygdala revealed by cortical and subcortical stimulation, in vivo. Neuroscience 106:613-620. CrossRef Medline