Thymic stromal lymphopoietin receptor blockade reduces allergic inflammation in a cynomolgus monkey model of asthma

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 2, 2013, Pages 455-462

  Cheng, Donavan T ^a   Ma, Cynthia ^a   Niewoehner, Jens ^b   Dahl, Martin ^a   Tsai, Angela ^a   Zhang, Jun ^a   Gonsiorek, Waldemar ^a   Apparsundaram, Subbu ^a   Pashine, Achal ^a   Ravindran, Palanikumar ^a   Jung, Jimmy ^a   Hang, Julie ^a   Allard, John ^a   Bitter, Hans ^a   Tribouley, Catherine ^a   Narula, Satwant ^a   Wilson, Stephen ^c   Fuentes, Maria E ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

allergen challenge; cynomolgus monkey; dendritic cells; eosinophilia; gene expression profiling; TH2 inflammation; Thymic stromal lymphopoietin

Indexed keywords

ALLERGEN; CYTOKINE RECEPTOR; INTERLEUKIN 13; MONOCLONAL ANTIBODY; THYMIC STROMAL LYMPHOPOIETIN; THYMIC STROMAL LYMPHOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

AIRWAY RESISTANCE; ALLERGIC INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CONTROLLED STUDY; CROSS REACTION; DENDRITIC CELL; EOSINOPHIL COUNT; EXPERIMENTAL MONKEY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; INFLAMMATION; LUNG LAVAGE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

AHR; AIRWAY HYPERRESPONSIVENESS; ALLERGEN CHALLENGE; ANTI-THYMIC STROMAL LYMPHOPOIETIN RECEPTOR ANTIBODY; BAL; BRONCHOALVEOLAR LAVAGE; CYNOMOLGUS MONKEY; DC; DENDRITIC CELL; DENDRITIC CELLS; EOSINOPHILIA; GENE EXPRESSION PROFILING; IC(50); INHIBITORY CONCENTRATION OF 50%; MDC; MYELOID DENDRITIC CELL; T(H)2 INFLAMMATION; THYMIC STROMAL LYMPHOPOIETIN; THYMIC STROMAL LYMPHOPOIETIN RECEPTOR; TSLP; TSLPR; TSLPR MAB;

ANIMALS; ANTIBODIES, MONOCLONAL; ASTHMA; CRICETINAE; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERSENSITIVITY; INFLAMMATION; MACACA FASCICULARIS; RECEPTORS, CYTOKINE; TH2 CELLS;

EID: 84881160767     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.05.011     Document Type: Article

References (27)

1. L. Cohn, J.A. Elias, and G.L. Chupp Asthma: mechanisms of disease persistence and progression Annu Rev Immunol 22 2004 789 815
2. Y.J. Liu TSLP in epithelial cell and dendritic cell cross talk Adv Immunol 101 2009 1 25
3. S.F. Ziegler Thymic stromal lymphopoietin and allergic disease J Allergy Clin Immunol 130 2012 845 852
4. A. Kato, S. Favoreto Jr., P.C. Avila, and R.P. Schleimer TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells J Immunol 179 2007 1080 1087
5. Z. Allakhverdi, M.R. Comeau, H.K. Jessup, B.R. Yoon, A. Brewer, and S. Chartier Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells J Exp Med 204 2007 253 258
6. L.S. Park, U. Martin, K. Garka, B. Gliniak, J.P. Di Santo, and W. Muller Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor J Exp Med 192 2000 659 670
7. A. Pandey, K. Ozaki, H. Baumann, S.D. Levin, A. Puel, and A.G. Farr Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin Nat Immunol 1 2000 59 64
8. V. Soumelis, P.A. Reche, H. Kanzler, W. Yuan, G. Edward, and B. Homey Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP Nat Immunol 3 2002 673 680
9. M.C. Siracusa, S.A. Saenz, D.A. Hill, B.S. Kim, M.B. Headley, and T.A. Doering TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation Nature 477 2011 229 233
10. D. Kaur, C. Doe, L. Woodman, W.Y. Wan, A. Sutcliffe, and F. Hollins Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin Chest 142 2012 76 85
11. D.F. Smelter, V. Sathish, M.A. Thompson, C.M. Pabelick, R. Vassallo, and Y.S. Prakash Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle J Immunol 185 2010 3035 3040
12. L. Shan, N.S. Redhu, A. Saleh, A.J. Halayko, J. Chakir, and A.S. Gounni Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways J Immunol 184 2010 7134 7143
13. M. Omori-Miyake, and S.F. Ziegler Mouse models of allergic diseases: TSLP and its functional roles Allergol Int 61 2012 27 34
14. B. Zhou, M.R. Comeau, T. De Smedt, H.D. Liggitt, M.E. Dahl, and D.B. Lewis Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice Nat Immunol 6 2005 1047 1053
15. D. Seshasayee, W.P. Lee, M. Zhou, J. Shu, E. Suto, and J. Zhang In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation J Clin Invest 117 2007 3868 3878
16. A. Al-Shami, R. Spolski, J. Kelly, A. Keane-Myers, and W.J. Leonard A role for TSLP in the development of inflammation in an asthma model J Exp Med 202 2005 829 839
17. S. Ying, B. O'Connor, J. Ratoff, Q. Meng, K. Mallett, and D. Cousins Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity J Immunol 174 2005 8183 8190
18. A. Shikotra, D.F. Choy, C.M. Ohri, E. Doran, C. Butler, and B. Hargadon Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma J Allergy Clin Immunol 129 2012 104 111 e1-9
19. D.F. Gudbjartsson, U.S. Bjornsdottir, E. Halapi, A. Helgadottir, P. Sulem, and G.M. Jonsdottir Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction Nat Genet 41 2009 342 347
20. G.M. Hunninghake, J. Lasky-Su, M.E. Soto-Quiros, L. Avila, C. Liang, and S.L. Lake Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans Am J Respir Crit Care Med 177 2008 830 836
21. J.Q. He, T.S. Hallstrand, D. Knight, M. Chan-Yeung, A. Sandford, and B. Tripp A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness J Allergy Clin Immunol 124 2009 222 229
22. Y. Benjamini, and Y. Hochberg Controlling the False discovery rate - a practical and powerful approach to multiple testing J R Stat Soc B 57 1995 289 300
23. A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, and M.A. Gillette Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles Proc Natl Acad Sci U S A 102 2005 15545 15550
24. S. Hanzelmann, R. Castelo, and J.G.S.V.A. Guinney gene set variation analysis for microarray and RNA-Seq data BMC Bioinformatics 14 2013 7
25. R.D. May, P.D. Monk, E.S. Cohen, D. Manuel, F. Dempsey, and N.H. Davis Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma Br J Pharmacol 166 2012 177 193
26. T.K. Hart, R.M. Cook, P. Zia-Amirhosseini, E. Minthorn, T.S. Sellers, and B.E. Maleeff Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys J Allergy Clin Immunol 108 2001 250 257
27. T. Ito, Y.H. Wang, O. Duramad, T. Hori, G.J. Delespesse, and N. Watanabe TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand J Exp Med 202 2005 1213 1223