Carryover does not affect results of Beckman Coulter highly-sensitive- AccuTnI assay on Access 2

Clinical Chemistry and Laboratory Medicine

Volumn 51, Issue 7, 2013, Pages

  Lippi, Giuseppe ^a   Avanzini, Paola ^a   Musa, Roberta ^a   Aloe, Rosalia ^a   Cervellin, Gianfranco ^b  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

^b ACADEMIC HOSPITAL OF PARMA   (Italy)

Author keywords

acute myocardial infarction; carryover; interference; troponin I

Indexed keywords

FIBRIN; HETEROPHILE ANTIBODY; MONOCLONAL ANTIBODY; TROPONIN I;

ACUTE HEART INFARCTION; ANALYZER; CLINICAL CHEMISTRY; CLINICAL LABORATORY; CONCENTRATION (PARAMETERS); EMERGENCY WARD; FALSE POSITIVE RESULT; HEART INJURY; HEART REHABILITATION; HEMOLYSIS; HUMAN; IMMUNOASSAY; INFORMATION SYSTEM; INFORMED CONSENT; INTENSIVE CARE UNIT; LETTER; OUTPATIENT; PRIORITY JOURNAL; ROOM TEMPERATURE; TEACHING HOSPITAL; VEIN PUNCTURE;

AUTOMATION, LABORATORY; FALSE POSITIVE REACTIONS; HUMANS; MYOCARDIAL INFARCTION; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING; TROPONIN I;

EID: 84881155677     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0889     Document Type: Letter

References (10)

1. Cardinaels EP, Mingels AM, Jacobs LH, Meex SJ, Bekers O, van Dieijen-Visser MP. A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: The challenges that lie ahead. Clin Chem Lab Med 2012;50:791-806.
2. Lippi G, Cervellin G. Degradation of troponin I in serum or plasma: Mechanisms, and analytical and clinical implications. Semin Thromb Hemost 2012;38:222-9.
3. Dimeski G. Evidence on the cause of false positive troponin I results with the Beckman AccuTnI method. Clin Chem Lab Med 2011;49:1079-80.
4. Kazmierczak SC, Catrou PG, Briley KP. Transient nature of interference effects from heterophile antibodies: Examples of interference with cardiac marker measurements. Clin Chem Lab Med 2000;38:33-9. (Pubitemid 30162791)
5. Lippi G, Avanzini P, Dipalo M, Aloe R, Cervellin G. Influence of hemolysis on troponin testing: Studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature. Clin Chem Lab Med 2011;49:2097-100.
6. Dimeski G, Jones B, Brown N. Carryover can be a cause of false-positive results with the Beckman AccuTnI assay. Clin Chem Lab Med 2012;50:1135-6.
7. Gould MJ, Wilgen U, Pretorius CJ. Probing indiscretions: Contamination of cardiac troponin reagent by very high patient samples causes false-positive results. Ann Clin Biochem 2012;49:395-8.
8. Apple FS, Ler R, Murakami MM. Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. Clin Chem 2012;58:1574-81.
9. Kavsak PA, MacRae AR, Yerna MJ, Jaffe AS. Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem 2009;55:573-7.
10. Apple FS, Collinson PO; IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 2012;58:54-61.