Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis

Journal of Perinatology

Volumn 33, Issue 8, 2013, Pages 622-626

  Cremer, M ^a   Weimann, A ^a   Szekessy, D ^a   Hammer, H ^a   Buhrer C ^a   Dame, C ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

erythroblast; mean platelet volume; nucleated red blood cells; platelet transfusion; thrombocytopenia

Indexed keywords

ARTICLE; BLOOD CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOWN REGULATION; ERYTHROCYTE COUNT; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; IMMATURE PLATELET FRACTION; MALE; MEGAKARYOPOIESIS; NECROTIZING ENTEROCOLITIS; NEWBORN; SEPSIS; THROMBOCYTE COUNT; THROMBOCYTE VOLUME; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

ENTEROCOLITIS, NECROTIZING; FEMALE; HEMATOPOIESIS; HUMANS; INFANT, NEWBORN; MALE; MEGAKARYOCYTES; PLATELET COUNT; SEPSIS; THROMBOCYTOPENIA;

EID: 84881148795     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2013.21     Document Type: Article

References (30)

1. Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr 1986; 108: 749-755
2. Baer VL, Lambert DK, Henry E, Christensen RD. Severe thrombocytopenia in the NICU. Pediatrics 2009; 124: E1095-e1100
3. Sola-Visner M, Sallmon H, Brown R. New insights into the mechanisms of nonimmune thrombocytopenia in neonates. Semin Perinatol 2009; 33: 43-51
4. Murray NA. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Acta Paediatr Suppl 2002; 91: 74-81
5. Brown RE, Rimsza LM, Pastos K, Young L, Saxonhouse MA, Bailey M et al. Effects of sepsis on neonatal thrombopoiesis. Pediatr Res. 2008; 64: 399-404
6. Kenton AB, Hegemier S, Smith EO, O'Donovan DJ, Brandt ML, Cass DL et al. Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity. J Perinatol 2005; 25: 173-177
7. Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X et al. Platelet-Activating factor induces TLR4 expression in intestinal epithelial cells: Implication for the pathogenesis of necrotizing enterocolitis. PLoS One 2010; 5: E15044
8. Roberts IA, Murray NA. Neonatal thrombocytopenia: New insights into pathogenesis and implications for clinical management. Curr Opin Pediatr 2001; 13: 16-21
9. Briggs C, Kunka S, Hart D, Oguni S, Machin SJ. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol 2004; 126: 93-99
10. Peterec SM, Brennan SA, Rinder HM, Wnek JL, Beardsley DS. Reticulated platelet values in normal and thrombocytopenic neonates. J Pediatr 1996; 129: 269-274
11. Joseph MA, Adams D, Maragos J, Saving KL. Flow cytometry of neonatal platelet RNA. J Pediatr Hematol Onc 1996; 18: 277-281
12. Cremer M, Paetzold J, Schmalisch G, Hammer H, Loui A, Dame C et al. Immature platelet fraction as novel laboratory parameter predicting the course of neonatal thrombocytopenia. Br J Haematol 2009; 144: 619-621
13. Cremer M, Weimann A, Schmalisch G, Hammer H, Buhrer C, Dame C. Immature platelet values indicate impaired megakaryopoietic activity in neonatal earlyonset thrombocytopenia. Thromb Haemost 2010; 103: 1016-1021
14. Ikeno K, Koike K, Takeshita A, Shinjo K, Higuchi T, Nakabayashi T et al. Stressful delivery influences circulating thrombopoietin (TPO) levels in newborns: Possible role for cortisol in TPO-mpl binding. Early Hum Dev 2000; 58: 225-235
15. Dame C. Developmental biology of thrombopoietin in the human fetus and neonate. Acta Paediatr Suppl 2002; 91: 54-65
16. Christensen RD, Henry E, Andres RL, Bennett ST. Reference ranges for blood concentrations of nucleated red blood cells in neonates. Neonatology 2011; 99: 289-294
17. Bayram F, Ozerkan K, Cengiz C, Develioglu O, Cetinkaya M. Perinatal asphyxia is associated with the umbilical cord nucleated red blood cell count in preeclamptic pregnancies. J Obstet Gynaecol 2010; 30: 383-386
18. Stachon A, Segbers E, Holland-Letz T, Kempf R, Hering S, Krieg M. Nucleated red blood cells in the blood of medical intensive care patients indicate increased mortality risk: A prospective cohort study. Crit Care 2007; 11: R62
19. Shah R, Reddy S, Horst HM, Stassinopoulos J, Jordan J, Rubinfeld I. Getting back to zero with nucleated red blood cells: Following trends is not necessarily a bad thing. Am J Surg 2012; 203: 343-345, discussion 5-6
20. Mehr S, Doyle LW. Cytokines as markers of bacterial sepsis in newborn infants: A review. Pediatr Infect Dis J 2000; 19: 879-887
21. Fowlie PW, Schmidt B. Diagnostic tests for bacterial infection from birth to 90 days-A systematic review. Arch Dis Child Fetal Neonatal Ed, 1998; 78: F92-F98
22. Batfalsky A, Lohr A, Heussen N, Neunhoeffer F, Orlikowsky TW. Diagnostic value of an interleukin-6 bedside test in term and preterm neonates at the time of clinical suspicion of early-And late-onset bacterial infection. Neonatology 2012; 102: 37-44
23. Albanyan A, Murphy MF, Wilcock M, Harrison P. Changes in the immature platelet fraction within ageing platelet concentrates. J Thrombosis Haemost 2008; 6: 2213-2215
24. Ruisi MM, Psaila B, Ward MJ, Villarica G, Bussel JB. Stability of measurement of the immature platelet fraction. Am J Hematol 2010; 85: 622-624
25. Jansson L. Relationship of mean platelet volume to platelet count in morphologic evaluation of thrombopoiesis. Scand J Haematol 1985; 35: 363-366
26. Diaz-Ricart M, Brunso L, Pino M, Navalon F, Jou JM, Heras M et al. Preanalytical treatment of EDTA-Anticoagulated blood to ensure stabilization of the mean platelet volume and component measured with the ADVIA counters. Thromb Res 2010; 126: E30-e35
27. Colarizi P, Fiorucci P, Caradonna A, Ficuccilli F, Mancuso M, Papoff P. Circulating thrombopoietin levels in neonates with infection. Acta Paediatr 1999; 88: 332-337
28. Hyman PE, Abrams CE, Zipser RD. Enhanced urinary immunoreactive thromboxane in neonatal necrotizing enterocolitis. A diagnostic indicator of thrombotic activity. Am J Dis Child 1987; 141: 686-689
29. Lambert MP, Rauova L, Bailey M, Sola-Visner MC, Kowalska MA, Poncz M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: Clinical and therapeutic implications. Blood 2007; 110: 1153-1160
30. Hennel E, Kentouche K, Beck J, Kiehntopf M, Boeer K. Immature platelet fraction as marker for platelet recovery after stem cell transplantation in children. Clin Biochem 2012; 45: 749-752