Resistance of optogenetically evoked motor function to global ischemia and reperfusion in mouse in vivo

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 8, 2013, Pages 1148-1152

  Xie, Yicheng ^a,b   Chen, Shangbin ^a,b   Anenberg, Eitan ^a,b   Murphy, Timothy H ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

brain recovery; cortical mapping; electrophysiology; global ischemia; reperfusion

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ELECTROENCEPHALOGRAM; IN VIVO STUDY; ISCHEMIA; MALE; MOTOR PERFORMANCE; MOTOR SYSTEM; MOUSE; MUSCLE CONTRACTION; NONHUMAN; OPTOGENETICS; PRIORITY JOURNAL; REPERFUSION;

ANIMALS; BRAIN ISCHEMIA; BRAIN MAPPING; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; LASERS; MALE; MICE; MICE, TRANSGENIC; NEUROIMAGING; PHYSICAL STIMULATION; REPERFUSION INJURY; RHODOPSIN;

EID: 84881141381     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.89     Document Type: Article

References (15)

1. Chen S, Mohajerani MH, Xie Y, Murphy TH. Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex. J Neurosci 2012; 32: 13510-13519.
2. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci 2009; 10: 861-872.
3. Carmichael ST. Brain excitability in stroke: the yin and yang of stroke progression. Arch Neurol 2012; 69: 161-167.
4. Murphy TH, Li P, Betts K, Liu R. Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines. J Neurosci 2008; 28: 1756-1772.
5. Nudo RJ. Mechanisms for recovery of motor function following cortical damage. Curr Opin Neurobiol 2006; 16: 638-644.
6. Ruscher K, Shamloo M, Rickhag M, Ladunga I, Soriano L, Gisselsson L et al. The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 2011; 134: 732-746.
7. Tennant KA, Adkins DL, Donlan NA, Asay AL, Thomas N, Kleim JA et al. The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture. Cereb Cortex 2011; 21: 865-876.
8. Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ et al. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron 2007; 54: 205-218.
9. Ayling OG, Harrison TC, Boyd JD, Goroshkov A, Murphy TH. Automated lightbased mapping of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice. Nat Methods 2009; 6: 219-224.
10. Lim DH, Mohajerani MH, Ledue J, Boyd J, Chen S, Murphy TH. In vivo large-scale cortical mapping using channelrhodopsin-2 stimulation in transgenic mice reveals asymmetric and reciprocal relationships between cortical areas. Front Neural Circuits 2012; 6: 11.
11. Bolay H, Dalkara T. Mechanisms of motor dysfunction after transient MCA occlusion: persistent transmission failure in cortical synapses is a major determinant. Stroke 1998; 29: 1988-1994.
12. Bolay H, Gursoy-Ozdemir Y, Sara Y, Onur R, Can A, Dalkara T. Persistent defect in transmitter release and synapsin phosphorylation in cerebral cortex after transient moderate ischemic injury. Stroke 2002; 33: 1369-1375.
13. Carvell GE, Simons DJ. Thalamic and corticocortical connections of the second somatic sensory area of the mouse. J Comp Neurol 1987; 265: 409-427.
14. Hossmann KA, Schmidt-Kastner R, Grosse Ophoff B. Recovery of integrative central nervous function after one hour global cerebro-circulatory arrest in normothermic cat. J Neurol Sci 1987; 77: 305-320.
15. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. J Neurosci 2011; 31: 11495-11504.