Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2

Clinical Rheumatology

Volumn 32, Issue 8, 2013, Pages 1147-1154

  Antonelli, Alessandro ^a   Fallahi, Poupak ^a   Ferrari, Silvia Martina ^a   Corrado, Alda ^a   Sebastiani, Marco ^b   Giuggioli, Dilia ^b   Miccoli, Mario ^a   Zignego, Anna Linda ^c   Sansonno, Domenico ^d   Marchi, Santino ^a   Ferri, Clodoveo ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

Chemokine (C C motif) ligand 2 (CCL2); Chemokine (C X C motif) ligand (CXCL)10; Chemokine (C X C motif) ligand (CXCL)11; Cryoglobulinemia; Interleukin 6

Indexed keywords

ALANINE AMINOTRANSFERASE; CORTICOSTEROID DERIVATIVE; CXCL11 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL EVALUATION; CLINICAL FEATURE; CONTROLLED STUDY; CRYOGLOBULINEMIA; FEMALE; HEPATITIS C; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TH1 CELL; TH2 CELL; VASCULITIS;

AGED; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHEMOKINE CCL2; CHEMOKINE CXCL10; CHEMOKINE CXCL11; CRYOGLOBULINEMIA; FEMALE; GENE EXPRESSION REGULATION; HEPATITIS C; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MIDDLE AGED; REGRESSION ANALYSIS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS;

EID: 84881137234     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-013-2246-y     Document Type: Article

References (41)

1. Ferri C, Antonelli A, Mascia MT, Sebastiani M, Fallahi P, Ferrari D, Pileri SA, Zignego AL (2007) HCV-related autoimmune and neoplastic disorders: the HCV syndrome. Dig Liver Dis 39(Suppl 1):S13-S21
2. Antonelli A, Ferri C, Galeazzi M, Giannitti C, Manno D, Mieli-Vergani G, Menegatti E, Olivieri I, Puoti M, Palazzi C, Roccatello D, Vergani D, Sarzi-Puttini P, Atzeni F (2008) HCV infection: pathogenesis, clinical manifestations and therapy. Clin Exp Rheumatol 26(1 Suppl 48):S39-S47
3. Antonelli A, Ferri C, Ferrari SM, Colaci M, Fallahi P (2008) Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia. Autoimmun Rev 8:18-23. doi: 10.1016/j.autrev.2008. 07.017
4. Antonelli A, Ferri C, Ferrari SM, Colaci M, Sansonno D, Fallahi P (2009) Endocrine manifestations of hepatitis C virus infection. Nat Clin Pract Endocrinol Metab 5:26-34. doi: 10.1038/ncpendmet1027
5. Antonelli A, Ferri C, Ferrari SM, Ghiri E, Goglia F, Pampana A, Bruschi F, Fallahi P (2009) Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia. Arthritis Rheum 60:3841-3847. doi: 10.1002/art.25003
6. Antonelli A, Ferri C, Fallahi P, Ferrari SM, Sebastiani M, Ferrari D, Giunti M, Frascerra S, Tolari S, Franzoni F, Galetta F, Marchi S, Ferrannini E (2008) High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. Am J Gastroenterol 103:2488-2494. doi: 10.1111/j.1572-0241.2008.02040.x
7. Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Carpi A, Nicolini A, Ferrannini E (2008) Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis C-associated cryoglobulinemia in the presence or absence of autoimmune thyroiditis. Metabolism 57:1270-1277. doi: 10.1016/j.metabol.2008.04
8. Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Franzoni F, Galetta F, Zignego AL, Ferrannini E (2009) CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C. Dig Liver Dis 41:42-48. doi: 10.1016/j.dld.2008.04.009
9. Sansonno D, Tucci FA, Troiani L, Lauletta G, Montrone M, Conteduca V, Sansonno L, Dammacco F (2008) Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. Blood 112:1620-1627. doi: 10.1182/blood-2008-02-137455
10. Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (1998) Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med 187:2009-2021. doi: 10.1084/jem.187.12.2009
11. Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998) The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). Cytogenet Cell Genet 81:271-272. doi: 10.1159/000015043
12. O'Donovan N, Galvin M, Morgan JG (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet Cell Genet 84:39-42. doi: 10.1159/000015209
13. Cox MA, Jenh CH, Gonsiorek W, Fine J, Narula SK, Zavodny PJ, Hipkin RW (2001) Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states. Mol Pharmacol 59:707-715
14. Romagnani P, Annunziato F, Lasagni L, Lazzeri E, Beltrame C, Francalanci M, Uguccioni M, Galli G, Cosmi L, Maurenzig L, Baggiolini M, Maggi E, Romagnani S, Serio M (2001) Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity. J Clin Invest 107:53-63. doi: 10.1172/JCI9775
15. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129-134. doi: 10.1084/jem.187.1.129
16. Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Sebastiani M, Franzoni F, Galetta F, Ferrannini E (2008) High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis. Cytokine 42:137-143. doi: 10.1016/j.cyto.2008.01.002
17. Ishak K, Baptista A, Bianchi L, Callea F, De Grootes J, Gudat F, Denk H, Desmet V, Korb G, MacSween RNM, Phillips MJ, Portmannl BG, Paulsen H, Scheuer PJ, Schmid M, Thaler H (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22:696-699. doi: 10.1016/0168-8278(95)80226-6
18. Antonelli A, Ferri C, Pampana A, Fallahi P, Nesti C, Pasquini M, Marchi S, Ferrannini E (2004) Thyroid disorders in chronic hepatitis C. Am J Med 117:10-13. doi: 10.1016/j.amjmed.2004.01.023
19. Antonelli A, Ferri C, Ferrari SM, Ghiri E, Marchi S, Sebastiani M, Fallahi P (2010) Serum concentrations of interleukin 1beta, CXCL10, and interferon-gamma in mixed cryoglobulinemia associated with hepatitis C infection. J Rheumatol 37:91-97. doi: 10.3899/jrheum.090246
20. Helbig KJ, Ruszkiewicz A, Semendric L, Harley HA, McColl SR, Beard MR (2004) Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation. Hepatology 39:1220-1229. doi: 10.1002/hep.20167
21. Bièche I, Asselah T, Laurendeau I, Vidaud D, Degot C, Paradis V, Bedossa P, Valla DC, Marcellin P, Vidaud M (2005) Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. Virology 332:130-144. doi: 10.1016/j/virol.2004.11.009
22. Zeremski M, Petrovic LM, Chiriboga L, Brown QB, Yee HT, Kinkhabwala M, Jacobson IM, Dimova R, Markatou M, Talal AH (2008) Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C. Hepatology 48:1440-1450. doi: 10.1002/hep.22500
23. Butera D, Marukian S, Iwamaye AE, Hembrador E, Chambers TJ, Di Bisceglie AM, Charles ED, Talal AH, Jacobson IM, Rice CM, Dustin LB (2005) Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C. Blood 106:1175-1182. doi: 10.1182/blood-2005-01-0126
24. Pockros PJ, Jeffers L, Afdhal N, Goodman ZD, Nelson D, Gish RG, Reddy KR, Reindollar R, Rodriguez-Torres M, Sullivan S, Blatt LM, Faris-Young S (2007) Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis. Hepatology 45:569-578. doi: 10.1002/hep.21561
25. Zeremski M, Dimova R, Brown Q, Jacobson IM, Markatou M, Talal AH (2009) Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection. J Infect Dis 200:1774-1780. doi: 10.1086/646614
26. Helbig KJ, Ruszkiewicz A, Lanford RE, Berzsenyi MD, Harley HA, McColl SR, Beard MR (2009) Differential expression of the CXCR3 ligands in chronic hepatitis C virus (HCV) infection and their modulation by HCV in vitro. J Virol 83:836-846. doi: 10.1128/JVI.01388-08
27. Antonelli A, Ferri C, Ferrari SM, Ruffilli I, Colaci M, Frascerra S, Miccoli M, Franzoni F, Galetta F, Fallahi P (2011) High serum levels of CXCL11 in mixed cryoglobulinemia are associated with increased circulating levels of interferon-{gamma}. J Rheumatol 38:1947-1952. doi: 10.3899/jrheum.110133
28. Panzer U, Steinmetz OM, Reinking RR, Meyer TN, Fehr S, Schneider A, Zahner G, Wolf G, Helmchen U, Schaerli P, Stahl RA, Thaiss F (2006) Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury. J Am Soc Nephrol 17:454-464. doi: 10.1681/ASN.2005040364
29. Takeuchi M, Oh-I K, Suzuki J, Hattori T, Takeuchi A, Okunuki Y, Usui Y, Usui M (2006) Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosis. Invest Ophthalmol Vis Sci 47:1063-1068. doi: 10.1167/iovs.05-0966
30. Antonelli A, Rotondi M, Fallahi P, Grosso M, Boni G, Ferrari SM, Romagnani P, Serio M, Mariani G, Ferrannini E (2007) Iodine-131 given for therapeutic purposes modulates differently interferon-{gamma}-inducible {alpha}-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter. J Clin Endocrinol Metab 92:1485-1490. doi: 10.1210/jc.2006-1571
31. Antonelli A, Rotondi M, Fallahi P, Romagnani P, Ferrari SM, Barani L, Ferrannini E, Serio M (2006) Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves' disease, and modulation by methimazole therapy. Clin Endocrinol (Oxf) 64:189-195. doi: 10.1111/j.1365-2265.2006.02447.x
32. Antonelli A, Fallahi P, Rotondi M, Ferrari SM, Serio M, Miccoli P (2006) Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy. Br J Surg 93:1226-1231. doi: 10.1002/bjs.5401
33. Franciotta D, Martino G, Zardini E, Furlan R, Bergamaschi R, Andreoni L, Cosi V (2001) Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies. J Neuroimmunol 115:192-198. doi: 10.1016/S0165-5728(01)00261-2
34. Gangur V, Simons FE, Hayglass KT (1998) Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses. FASEB J 12:705-713
35. Antonelli A, Fallahi P, Rotondi M, Ferrari SM, Romagnani P, Grosso M, Ferrannini E, Serio M (2006) Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process. Eur J Endocrinol 154:651-658. doi: 10.1530/eje.1.02137
36. Hosokawa Y, Hosokawa I, Ozaki K, Nakae H, Matsuo T (2009) Cytokines differentially regulate CXCL10 production by interferon-gamma-stimulated or tumor necrosis factor-alpha-stimulated human gingival fibroblasts. J Periodontal Res 44:225-231. doi: 10.1111/j.1600-0765.2008.01124.x
37. Okuno T, Andoh A, Bamba S, Araki Y, Fujiyama Y, Fujiyama M, Bamba T (2002) Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts. Scand J Gastroenterol 37:317-324. doi: 10.1080/ 003655202317284228
38. Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, Villa E, Menichetti F, Fallahi P (2010) Interleukin-1β, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis. J Interferon Cytokine Res 30:835-842. doi: 10.1089/jir.2010.0024
39. Hwang CJ, Afifiyan N, Sand D, Naik V, Said J, Pollock SJ, Chen B, Phipps RP, Goldberg RA, Smith TJ, Douglas RS (2009) Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. Invest Ophthalmol Vis Sci 50:2262-2268. doi: 10.1167/iovs.08-2328
40. Yu N, Zhang S, Zuo F, Kang K, Guan M, Xiang L (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J Dermatol Sci 56:113-120. doi: 10.1016/j.jdermsci.2009.08.003
41. Wong CK, Cao J, Yin YB, Lam CW (2010) Interleukin-17A activation on bronchial epithelium and basophils: a novel inflammatory mechanism. Eur Respir J 35:883-893. doi: 10.1183/09031936.00088309