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Volumn 49, Issue 13, 2013, Pages 2806-2814

Impact of geriatric risk factors on pegylated liposomal doxorubicin tolerance and efficacy in elderly metastatic breast cancer patients: Final results of the DOGMES multicentre GINECO trial

Author keywords

doxorubicin; Geriatric ageing; Liposomal pegylated; Metastatic breast cancer

Indexed keywords

ALBUMIN; DOXORUBICIN; EPIRUBICIN; PYRIDOXINE;

EID: 84881107431     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.04.027     Document Type: Article
Times cited : (28)

References (37)
  • 1
    • 3042628862 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival
    • A. Jemal, L.X. Clegg, and E. Ward Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival Cancer 101 1 2004 3 27
    • (2004) Cancer , vol.101 , Issue.1 , pp. 3-27
    • Jemal, A.1    Clegg, L.X.2    Ward, E.3
  • 2
    • 31544446658 scopus 로고    scopus 로고
    • Dealing with metastatic breast cancer in elderly women: Results from a French study on a large cohort carried out by the 'Observatory on Elderly Patients'
    • G. Freyer, A.C. Braud, and P. Chaibi Dealing with metastatic breast cancer in elderly women: results from a French study on a large cohort carried out by the 'Observatory on Elderly Patients' Ann Oncol 17 2 2006 211 216
    • (2006) Ann Oncol , vol.17 , Issue.2 , pp. 211-216
    • Freyer, G.1    Braud, A.C.2    Chaibi, P.3
  • 3
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65 years of age or older in cancer-treatment trials
    • L.F. Hutchins, J.M. Unger, J.J. Crowley, C.A. Coltman Jr., and K.S. Albain Underrepresentation of patients 65 years of age or older in cancer-treatment trials N Engl J Med 341 27 1999 2061 2067
    • (1999) N Engl J Med , vol.341 , Issue.27 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3    Coltman, Jr.C.A.4    Albain, K.S.5
  • 4
    • 20044388527 scopus 로고    scopus 로고
    • Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer
    • H.B. Muss, S. Woolf, and D. Berry Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer JAMA 293 9 2005 1073 1081
    • (2005) JAMA , vol.293 , Issue.9 , pp. 1073-1081
    • Muss, H.B.1    Woolf, S.2    Berry, D.3
  • 5
    • 0026639451 scopus 로고
    • Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience [see comment]
    • K. Christman, H.B. Muss, L.D. Case, and V. Stanley Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience [see comment] JAMA 268 1 1992 57 62
    • (1992) JAMA , vol.268 , Issue.1 , pp. 57-62
    • Christman, K.1    Muss, H.B.2    Case, L.D.3    Stanley, V.4
  • 6
    • 0029996460 scopus 로고    scopus 로고
    • Doxorubicin-based chemotherapy in elderly patients with metastatic breast cancer. Tolerance and outcome
    • N.K. Ibrahim, D.K. Frye, A.U. Buzdar, R.S. Walters, and G.N. Hortobagyi Doxorubicin-based chemotherapy in elderly patients with metastatic breast cancer. Tolerance and outcome Arch Intern Med 156 8 1996 882 888
    • (1996) Arch Intern Med , vol.156 , Issue.8 , pp. 882-888
    • Ibrahim, N.K.1    Frye, D.K.2    Buzdar, A.U.3    Walters, R.S.4    Hortobagyi, G.N.5
  • 7
    • 84859140429 scopus 로고    scopus 로고
    • Management of elderly patients with breast cancer: Updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA)
    • Epub 2012 March 30
    • L. Biganzoli, H. Wildiers, and C. Oakman Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA) Lancet Oncol 13 4 2012 e148 e160 Epub 2012 March 30
    • (2012) Lancet Oncol , vol.13 , Issue.4
    • Biganzoli, L.1    Wildiers, H.2    Oakman, C.3
  • 8
    • 0038521374 scopus 로고    scopus 로고
    • Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials
    • S.M. Swain, F.S. Whaley, and M.S. Ewer Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials Cancer 97 11 2003 2869 2879
    • (2003) Cancer , vol.97 , Issue.11 , pp. 2869-2879
    • Swain, S.M.1    Whaley, F.S.2    Ewer, M.S.3
  • 9
    • 0037680647 scopus 로고    scopus 로고
    • The effect of age on the early disposition of doxorubicin
    • J. Li, and P.R. Gwilt The effect of age on the early disposition of doxorubicin Cancer Chemother Pharmacol 51 5 2003 395 402
    • (2003) Cancer Chemother Pharmacol , vol.51 , Issue.5 , pp. 395-402
    • Li, J.1    Gwilt, P.R.2
  • 11
    • 79251583764 scopus 로고    scopus 로고
    • Anthracycline cardiotoxicity in the elderly cancer patient: A SIOG expert position paper
    • Epub 2010 October 18
    • M. Aapro, C. Bernard-Marty, and E.G. Brain Anthracycline cardiotoxicity in the elderly cancer patient: a SIOG expert position paper Ann Oncol 22 2 2011 257 267 Epub 2010 October 18
    • (2011) Ann Oncol , vol.22 , Issue.2 , pp. 257-267
    • Aapro, M.1    Bernard-Marty, C.2    Brain, E.G.3
  • 12
    • 21344436609 scopus 로고    scopus 로고
    • First-line gemcitabine versus epirubicin in postmenopausal women aged 60 or older with metastatic breast cancer: A multicenter, randomized, phase III study
    • O. Feher, P. Vodvarka, and J. Jassem First-line gemcitabine versus epirubicin in postmenopausal women aged 60 or older with metastatic breast cancer: a multicenter, randomized, phase III study Ann Oncol 16 6 2005 899 908
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 899-908
    • Feher, O.1    Vodvarka, P.2    Jassem, J.3
  • 13
    • 11144357506 scopus 로고    scopus 로고
    • Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    • M.E. O'Brien, N. Wigler, and M. Inbar Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer Ann Oncol 15 3 2004 440 449
    • (2004) Ann Oncol , vol.15 , Issue.3 , pp. 440-449
    • O'Brien, M.E.1    Wigler, N.2    Inbar, M.3
  • 14
    • 0942277118 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin in the treatment of breast cancer
    • J.A. O'Shaughnessy Pegylated liposomal doxorubicin in the treatment of breast cancer Clin Breast Cancer 4 5 2003 318 328
    • (2003) Clin Breast Cancer , vol.4 , Issue.5 , pp. 318-328
    • O'Shaughnessy, J.A.1
  • 15
    • 84881085116 scopus 로고    scopus 로고
    • Biweekly liposomal pegylated doxorubicin in elderly women with advanced breast cancer: A prospective multicenter trial on tolerability and cardiotoxicity
    • Abstr. 1138
    • U. Basso, A. Roma, and C. Falci Biweekly liposomal pegylated doxorubicin in elderly women with advanced breast cancer: a prospective multicenter trial on tolerability and cardiotoxicity J Clin Oncol 28 15s 2010 Abstr. 1138
    • (2010) J Clin Oncol , vol.28 , Issue.S15
    • Basso, U.1    Roma, A.2    Falci, C.3
  • 16
    • 45249099512 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin in elderly patients with metastatic breast cancer
    • A.M. Minisini, C. Andreetta, G. Fasola, and F. Puglisi Pegylated liposomal doxorubicin in elderly patients with metastatic breast cancer Expert Rev Anticancer Ther 8 3 2008 331 342
    • (2008) Expert Rev Anticancer Ther , vol.8 , Issue.3 , pp. 331-342
    • Minisini, A.M.1    Andreetta, C.2    Fasola, G.3    Puglisi, F.4
  • 17
    • 84898675891 scopus 로고    scopus 로고
    • Can we predict chemo-induced hematotoxicity in elderly patients treated with Pegylated Liposomal Doxorubicin? Results of a population-based model derived from the DOGMES phase II trial of the GINECO
    • A. Sostelly, E. Henin, and L. Chauvenet Can we predict chemo-induced hematotoxicity in elderly patients treated with Pegylated Liposomal Doxorubicin? Results of a population-based model derived from the DOGMES phase II trial of the GINECO J Geriatr Oncol 4 1 2013 48 57
    • (2013) J Geriatr Oncol , vol.4 , Issue.1 , pp. 48-57
    • Sostelly, A.1    Henin, E.2    Chauvenet, L.3
  • 18
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • R. Simon Optimal two-stage designs for phase II clinical trials Control Clin Trials 10 1 1989 1 10
    • (1989) Control Clin Trials , vol.10 , Issue.1 , pp. 1-10
    • Simon, R.1
  • 19
    • 84856338945 scopus 로고    scopus 로고
    • Predicting the risk of chemotherapy toxicity in older patients: The Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score
    • M. Extermann, I. Boler, and R.R. Reich Predicting the risk of chemotherapy toxicity in older patients: The Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score Cancer 9 2011 26646
    • (2011) Cancer , vol.9 , pp. 26646
    • Extermann, M.1    Boler, I.2    Reich, R.R.3
  • 20
    • 80052704591 scopus 로고    scopus 로고
    • Predicting chemotherapy toxicity in older adults with cancer: A prospective multicenter study
    • A. Hurria, K. Togawa, and S.G. Mohile Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study J Clin Oncol 29 25 2011 3457 3465
    • (2011) J Clin Oncol , vol.29 , Issue.25 , pp. 3457-3465
    • Hurria, A.1    Togawa, K.2    Mohile, S.G.3
  • 21
    • 74549222946 scopus 로고    scopus 로고
    • A multicentric observational trial of pegylated liposomal doxorubicin for metastatic breast cancer
    • J. Huober, W. Fett, and A. Nusch A multicentric observational trial of pegylated liposomal doxorubicin for metastatic breast cancer BMC Cancer 10 2010 2
    • (2010) BMC Cancer , vol.10 , pp. 2
    • Huober, J.1    Fett, W.2    Nusch, A.3
  • 22
    • 33646790875 scopus 로고    scopus 로고
    • 2 every 4 weeks in previously treated patients with metastatic breast cancer
    • Epub 2006 April 26
    • 2 every 4 weeks in previously treated patients with metastatic breast cancer Oncology 70 2 2006 141 146 Epub 2006 April 26
    • (2006) Oncology , vol.70 , Issue.2 , pp. 141-146
    • Al-Batran, S.E.1    Meerpohl, H.G.2    Von Minckwitz, G.3
  • 23
    • 33845332087 scopus 로고    scopus 로고
    • A joined analysis of two European Organization for the Research and Treatment of Cancer (EORTC) studies to evaluate the role of pegylated liposomal doxorubicin (Caelyx) in the treatment of elderly patients with metastatic breast cancer
    • Epub 2006 November 20
    • L. Biganzoli, R. Coleman, and A. Minisini A joined analysis of two European Organization for the Research and Treatment of Cancer (EORTC) studies to evaluate the role of pegylated liposomal doxorubicin (Caelyx) in the treatment of elderly patients with metastatic breast cancer Crit Rev Oncol Hematol 61 1 2007 84 89 Epub 2006 November 20
    • (2007) Crit Rev Oncol Hematol , vol.61 , Issue.1 , pp. 84-89
    • Biganzoli, L.1    Coleman, R.2    Minisini, A.3
  • 24
    • 33646485684 scopus 로고    scopus 로고
    • A randomised phase II study of two different schedules of pegylated liposomal doxorubicin in metastatic breast cancer (EORTC-10993)
    • Epub 2006 March 7
    • R.E. Coleman, L. Biganzoli, and P. Canney A randomised phase II study of two different schedules of pegylated liposomal doxorubicin in metastatic breast cancer (EORTC-10993) Eur J Cancer 42 7 2006 882 887 Epub 2006 March 7
    • (2006) Eur J Cancer , vol.42 , Issue.7 , pp. 882-887
    • Coleman, R.E.1    Biganzoli, L.2    Canney, P.3
  • 25
    • 10844258361 scopus 로고    scopus 로고
    • Phase II study of single-agent pegylated liposomal doxorubicin HCl (PLD) in metastatic breast cancer after first-line treatment failure
    • B. Mlineritsch, P. Mayer, and C. Rass Phase II study of single-agent pegylated liposomal doxorubicin HCl (PLD) in metastatic breast cancer after first-line treatment failure Onkologie 27 5 2004 441 446
    • (2004) Onkologie , vol.27 , Issue.5 , pp. 441-446
    • Mlineritsch, B.1    Mayer, P.2    Rass, C.3
  • 26
    • 80052032897 scopus 로고    scopus 로고
    • Single-agent pegylated liposomal doxorubicin (PLD) in the treatment of metastatic breast cancer: Results of an Austrian observational trial
    • M. Fiegl, B. Mlineritsch, M. Hubalek, R. Bartsch, U. Pluschnig, and G.G. Steger Single-agent pegylated liposomal doxorubicin (PLD) in the treatment of metastatic breast cancer: results of an Austrian observational trial BMC Cancer 11 2011 373 379
    • (2011) BMC Cancer , vol.11 , pp. 373-379
    • Fiegl, M.1    Mlineritsch, B.2    Hubalek, M.3    Bartsch, R.4    Pluschnig, U.5    Steger, G.G.6
  • 27
    • 0030959798 scopus 로고    scopus 로고
    • Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: Results of a multicenter phase II trial
    • M.R. Ranson, J. Carmichael, K. O'Byrne, S. Stewart, D. Smith, and A. Howell Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial J Clin Oncol 15 10 1997 3185 3191
    • (1997) J Clin Oncol , vol.15 , Issue.10 , pp. 3185-3191
    • Ranson, M.R.1    Carmichael, J.2    O'Byrne, K.3    Stewart, S.4    Smith, D.5    Howell, A.6
  • 28
    • 20244368234 scopus 로고    scopus 로고
    • Safety and efficacy of two different doses of capecitabine in the treatment of advanced breast cancer in older women
    • Epub 2005 February 14
    • E. Bajetta, G. Procopio, and L. Celio Safety and efficacy of two different doses of capecitabine in the treatment of advanced breast cancer in older women J Clin Oncol 23 10 2005 2155 2161 Epub 2005 February 14
    • (2005) J Clin Oncol , vol.23 , Issue.10 , pp. 2155-2161
    • Bajetta, E.1    Procopio, G.2    Celio, L.3
  • 29
    • 27744444804 scopus 로고    scopus 로고
    • Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: A GINECO study
    • G. Freyer, J.F. Geay, and S. Touzet Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study Ann Oncol 16 11 2005 1795 1800
    • (2005) Ann Oncol , vol.16 , Issue.11 , pp. 1795-1800
    • Freyer, G.1    Geay, J.F.2    Touzet, S.3
  • 30
    • 58349111900 scopus 로고    scopus 로고
    • Predictors of treatment failures during chemotherapy: A prospective study on 110 older cancer patients
    • Epub 2008 March 11
    • R. Marinello, D. Marenco, and D. Roglia Predictors of treatment failures during chemotherapy: a prospective study on 110 older cancer patients Arch Gerontol Geriatr 48 2 2009 222 226 Epub 2008 March 11
    • (2009) Arch Gerontol Geriatr , vol.48 , Issue.2 , pp. 222-226
    • Marinello, R.1    Marenco, D.2    Roglia, D.3
  • 31
    • 79952758122 scopus 로고    scopus 로고
    • Pharmacokinetic study of pegylated liposomal doxorubicin (PLD) in patients over 70: Association with increasing age and cutaneous toxicity
    • Abstr. 9155
    • A. Bononi, M. Gusella, and I. Modena Pharmacokinetic study of pegylated liposomal doxorubicin (PLD) in patients over 70: association with increasing age and cutaneous toxicity J Clin Oncol 28 7s 2010 44 Abstr. 9155
    • (2010) J Clin Oncol , vol.28 , Issue.S7 , pp. 44
    • Bononi, A.1    Gusella, M.2    Modena, I.3
  • 32
    • 0030058847 scopus 로고    scopus 로고
    • Early lymphopenia after cytotoxic chemotherapy as a risk factor for febrile neutropenia
    • J.Y. Blay, F. Chauvin, and A. Le Cesne Early lymphopenia after cytotoxic chemotherapy as a risk factor for febrile neutropenia J Clin Oncol 14 2 1996 636 643
    • (1996) J Clin Oncol , vol.14 , Issue.2 , pp. 636-643
    • Blay, J.Y.1    Chauvin, F.2    Le Cesne, A.3
  • 33
    • 33644934203 scopus 로고    scopus 로고
    • Effect of creatinine clearance on patterns of toxicity in older patients receiving adjuvant chemotherapy for breast cancer
    • A. Hurria, K. Brogan, and K.S. Panageas Effect of creatinine clearance on patterns of toxicity in older patients receiving adjuvant chemotherapy for breast cancer Drugs Aging 22 9 2005 785 791
    • (2005) Drugs Aging , vol.22 , Issue.9 , pp. 785-791
    • Hurria, A.1    Brogan, K.2    Panageas, K.S.3
  • 34
    • 84859948169 scopus 로고    scopus 로고
    • Impact of geriatric vulnerability parameters on pegylated liposomal doxorubicin (PLD) tolerance and outcome in elderly patients with metastatic breast cancer: Results of the DOGMES multicenter phase II GINECO trial
    • Abstr. 9122
    • C. Falandry, E. Brain, and M. Bonnefoy Impact of geriatric vulnerability parameters on pegylated liposomal doxorubicin (PLD) tolerance and outcome in elderly patients with metastatic breast cancer: results of the DOGMES multicenter phase II GINECO trial J Clin Oncol 29 Suppl. 2011 Abstr. 9122
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Falandry, C.1    Brain, E.2    Bonnefoy, M.3
  • 35
    • 0344737935 scopus 로고    scopus 로고
    • Comprehensive geriatric assessment
    • D. Wieland, and V. Hirth Comprehensive geriatric assessment Cancer Control 10 2003 454 462
    • (2003) Cancer Control , vol.10 , pp. 454-462
    • Wieland, D.1    Hirth, V.2
  • 36
    • 0026031194 scopus 로고
    • The timed "up & Go": A test of basic functional mobility for frail elderly persons
    • D. Podsiallo, and S. Richardson The timed "Up & Go": a test of basic functional mobility for frail elderly persons J Am Geriatr Soc 39 1991 142 148
    • (1991) J Am Geriatr Soc , vol.39 , pp. 142-148
    • Podsiallo, D.1    Richardson, S.2
  • 37
    • 0037048878 scopus 로고    scopus 로고
    • The 5 words: A simple and sensitive test for the diagnosis of Alzheimer's disease
    • B. Dubois, J. Touchon, and F. Portet The 5 words: a simple and sensitive test for the diagnosis of Alzheimer's disease Press Med 9 2002 1696 1699
    • (2002) Press Med , vol.9 , pp. 1696-1699
    • Dubois, B.1    Touchon, J.2    Portet, F.3


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