Nonvolatile salt-free stabilizer for the quantification of polar imipenem and cilastatin in human plasma using hydrophilic interaction chromatography/quadrupole mass spectrometry with contamination sensitive off-axis electrospray

Journal of Mass Spectrometry

Volumn 48, Issue 8, 2013, Pages 945-950

  Hu, Zhe Yi ^a   Boucher, Bradley A ^a   Laizure, S Casey ^a   Herring, Vanessa L ^a   Parker, Robert B ^a   Hickerson, William L ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

cilastatin; hydrophilic interaction chromatography quadrupole mass spectrometry; imipenem; off axis electrospray; pharmacokinetics

Indexed keywords

BIOLOGICAL SAMPLES; CILASTATIN; ELECTROSPRAYS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IMIPENEM; MATRIX EFFECTS; PLASMA SAMPLES; SENSITIVE DETECTION;

ACETONITRILE; CHROMATOGRAPHY; DATA STORAGE EQUIPMENT; HYDROPHILICITY; ION SOURCES; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMA (HUMAN); TISSUE;

PLASMAS;

ACETONITRILE; ANTIBIOTIC AGENT; CILASTATIN; CLOPIDOGREL; IMIPENEM; METHANOL; OSELTAMIVIR;

ACCURACY; ANALYTICAL EQUIPMENT; ANTIBIOTIC THERAPY; ARTICLE; BURN; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG STRUCTURE; HEMOFILTRATION; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MASS SPECTROMETRY; MOLECULAR INTERACTION; OFF AXIS ELECTROSPRAY MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REPRODUCIBILITY;

CILASTATIN; HYDROPHILIC INTERACTION CHROMATOGRAPHY/QUADRUPOLE MASS SPECTROMETRY; IMIPENEM; OFF-AXIS ELECTROSPRAY; PHARMACOKINETICS;

ACETONITRILES; CHROMATOGRAPHY, LIQUID; CILASTATIN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMIPENEM; LINEAR MODELS; METHANOL; OSELTAMIVIR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84881103267     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3240     Document Type: Article

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