C-src Enriched Serum Microvesicles Are Generated in Malignant Plasma Cell Dyscrasia

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Di Noto, Giuseppe ^a   Paolini, Lucia ^a   Zendrini, Andrea ^a   Radeghieri, Annalisa ^a   Caimi, Luigi ^a   Ricotta, Doris ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEAT SHOCK PROTEIN 70; LIPOCORTIN 5; PROTEIN C SRC; UNCLASSIFIED DRUG;

AMYLOIDOSIS; ARTICLE; BLOOD SAMPLING; CELL METABOLISM; CONTROLLED STUDY; ENDOTHELIUM CELL; EXOSOME; EXTRACELLULAR SPACE; HEART MUSCLE CELL; HEMATOLOGICAL PARAMETERS; HUMAN; HUMAN CELL; INTERNALIZATION; KAPPA FREE LIGHT CHAIN; LAMBDA FREE LIGHT CHAIN; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PLASMA CELL DYSCRASIA; PROTEIN FUNCTION;

EID: 84881095742     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070811     Document Type: Article

References (43)

1. Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, et al. (2006) Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med354(13): 1362-1369.
2. Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, et al. (2010) Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia24(6): 1121-1127.
3. Kyle RA, Remstein ED, Therneau TM, Dispenzieri A, Kurtin PJ, et al. (2007) Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N Engl J Med 356(25): 2582-2590.
4. Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM, (2009) A monoclonal gammopathy precedes multiple myeloma in most patients. Blood113(22): 5418-22.
5. Matsumori A, Shimada M, Jie X, Higuchi H, Groot Kormelink T, et al. (2010) Effect of free immunoglobulin light chains on viral myocarditis. Circ Res 106(9): 1533-40.
6. Bradwell AR (2009) Serum free light chain publications. Available: http//wikilite.com/wiki/index.php/Immunoassays_for_free_light_chain_ measurement. Accessed 2013 June 4.
7. Rajkumar SV, Kyle RA, Therneau TM, Melton LJ 3rd, Bradwell AR, et al. (2005) Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 106(3): 812-7.
8. Dispenzieri A, Kyle RA, Katzmann JA, Therneau TM, Larson D, et al. (2008) Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood 111(2): 785-789.
9. Pérez-Persona E, Vidriales MB, Mateo G, García-Sanz R, Mateos MV, et al. (2007) New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. Blood 110(7): 2586-2592.
10. Rajkumar SV, Kyle RA, Buadi FK, (2010) Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clin Proc85(10): 945-8.
11. Kyrtsonis MC, Vassilakopoulos TP, Kafasi N, Sachanas S, Tzenou T, et al. (2007) Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. Br J Haematol 137(3): 240-3.
12. Snozek CL, Katzmann JA, Kyle RA, Dispenzieri A, Larson DR, et al. (2008) Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: Proposed incorporation into the international staging system. Leukemia. 22(10): 1933-7.
13. Merlini G, Bellotti V, (2003) Molecular mechanisms of amyloidosis. N Engl J Med 349(6): 583-96.
14. Obici L, Perfetti V, Palladini G, Moratti R, Merlini G, (2005) Clinical aspects of systemic amyloid diseases. Biochim Biophys Acta 1753(1): 11-22.
15. Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, et al. (2003) Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 78(1): 21-33.
16. Herrera GA, (2009) Renal Lesions Associated With Plasma Cell Dyscrasias Practical Approach to Diagnosis, New Concepts, and Challenges. Arch Pathol Lab Med 133(2): 249-67.
17. Falk RH, Comenzo RL, Skinner M, (1997) The systemic amyloidosis. N Engl J Med 337(13): 898-909.
18. Butch AW, Kelly KA, Munshi NC, (2001) Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein. Exp Hematol 29(1): 85-92.
19. Monis GF, Schultz C, Ren R, Eberhard J, Costello C, et al. (2006) Role of Endocytic Inhibitory Drugs on Internalization of Amyloidogenic Light Chains by Cardiac Fibroblast. Am J Pathol 169(6): 1939-1952.
20. Teng J, Russell WJ, Gu X, Cardelli J, Jones ML, et al. (2004) Different types of glomerulopathic light chains interact with mesangial cells using a common receptor but exhibit different intracellular trafficking patterns. Lab Invest. 84(4): 440-51.
21. Ying WZ, Wang PX, Aaron KJ, Basnayake K, Sanders PW, (2011) Immunoglobulin light chains activate nuclear factor-κB in renal epithelial cells through a Src-dependent mechanism. Blood117(4): 1301-7.
22. Lavatelli F, Brambilla F, Valentini V, Rognoni P, Casarini S, et al. (2011) A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum. Biochim Biophys Acta 1814(3): 409-19.
23. Pant S, Hilton H, Burczynski ME, (2012) The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem Pharmacol 83(11): 1484-94.
24. Kharaziha P, Ceder S, Li Q, Panaretakis T, (2012) Tumor cell-derived exosomes: A message in a bottle. Biochim et Biophys Acta 1826 (1): 103-111.
25. Zadeh MS, Kolb JP, Geromin D, D'Anna R, Boulmerka A, et al. (2000) Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. Leukoc Biol 67(3): 327-34.
26. Tauro BJ, Greening DW, Mathias RA, Ji H, Mathivanan S, et al. (2012) Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods 56(2): 293-304.
27. Koga K, Matsumoto K, Akiyoshi T, Kubo M, Yamanaka N, et al. (2005) Purification, characterization and biological significance of tumor-derived exosomes. Anticancer Res 25(6A): 3703-7.
28. Paolini L, Radeghieri A, Civini S, Caimi L, Ricotta D, (2011) The epsilon hinge-ear region regulates membrane localization of the AP-4 complex. Traffic12(11): 1604-19.
29. Keeling J, Teng J, Herrera GA, (2004) AL-amyloidosis and light-chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. Lab Invest 84(10): 1322-38.
30. Schneider A, Simons M, (2012) Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statins. J Neurochemistry 120 (1): 1-3.
31. Vingtdeux V, Sergeant N, Buée L, (2012) Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer's Disease. Front Physiol 3: 229.
32. Lori CK, Song L, Eric BH, (2009) Src kinases as therapeutic targets for cancer. Nature Reviews Clinical Oncology 6: 587-595.
33. Mathivanan S, Ji H, Simpson RJ, (2010) Exosomes: Extracellular organelles important in intercellular communication. J Proteomics 10 73(10): 1907-20.
34. Johnstone RM, (2006) Exosomes biological significance: A concise review. Blood Cells Mol Dis. 36(2): 315-21.
35. Logozzi M, De Milito A, Lugini L, Borghi M, Calabrò L, et al. (2009) High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS One 4(4): e5219.
36. Mineo M, Garfield SH, Taverna S, Flugy A, De Leo G, et al. (2012) Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion. Angiogenesis 15(1): 33-45.
37. Masyuk AI, Huang BQ, Ward CJ, Gradilone SA, Banales JM, et al. (2010) Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. Am J Physiol Gastrointest Liver Physiol 299(4): G990-9.
38. Fevrier B, Vilette D, Archer F, Loew D, Faigle W, et al. (2004) Cells release prions in association with exosomes. Proc Natl Acad Sci U S A 101(26): 9683-8.
39. Alais S, Simoes S, Baas D, Lehmann S, Raposo G, et al. (2008) Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles. Biol Cell 100(10): 603-15.
40. Ramirez-Alvarado M, Ward CJ, Huang BQ, Gong X, Hogan MC, et al. (2012) Differences in Immunoglobulin Light Chain Species Found in Urinary Exosomes in Light Chain Amyloidosis (AL). PLoS One 7(6): e38061.
41. Thomas LM, Salter RD, (2010) Activation of macrophages by P2X7-induced microvesicles from myeloid cells is mediated by phospholipids and is partially dependent on TLR4. J Immunol185(6): 3740-9.
42. Chen GY, Nuñez G, (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10(12): 826-37.
43. Sengul S, Zwizinski C, Simon EE, Kapasi A, Singhal PC, et al. (2002) Endocytosis of light chains induces cytokines through activation of NF-kappaB in human proximal tubule cells. Kidney Int 62(6): 1977-88.