Management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): The studies, the evidence, and the impact

World Journal of Urology

Volumn 31, Issue 4, 2013, Pages 747-753

  Nickel, J Curtis ^a   Shoskes, Daniel A ^b   Wagenlehner, Florian M E ^c  

^a QUEEN S UNIVERSITY   (Canada)

^b LERNER RESEARCH INSTITUTE   (United States)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Chronic pelvic pain syndrome; Chronic prostatitis; Evidence based; Randomized placebo controlled trials; Treatment

Indexed keywords

ARTICLE; EVIDENCE BASED MEDICINE; HUMAN; MALE; PROSTATITIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME;

EVIDENCE-BASED MEDICINE; HUMANS; MALE; PROSTATITIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84881080220     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-013-1062-y     Document Type: Article

References (48)

1. Krieger JN, Nyberg L, Nickel JC (1999) NIH consensus definition and classification of prostatitis. JAMA 282: 236-237.
2. Schaeffer AJ (2008) Chronic prostatiitis and chronic pelvic pain syndrome. NEJM 355: 1690-1698.
3. Litwin MS, McNaughton-Collins M, Fowler FJ Jr, Nickel JC, Calhoun EA, Pontari MA, Alexander RB, Farrar JT, O'Leary MP (1999) The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network. J Urol. 162: 369-375.
4. Propert KJ, Wang Y, Alexander R, Calhoun EA, Nickel JC, O'Leary M, Pontari M, Litwin M, McNaughton-Collins M, the Chronic Prostatitis Collaborative Research Network (CPCRN) (2006) Responsiveness of the NIH-CPSI. QOL Res 15(2): 299-305.
5. Zhou Z, Hong L, Shen X et al (2008) Detection of nanobacteria infection in type III prostatitis. Urology 71: 1091.
6. Nickel JC, Downey J, Clark J et al (2003) Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo-controlled multicenter trial. Urology 62: 614-617.
7. Alexander RB, Propert KJ, Schaeffer AJ et al (2004) Ciprofloxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial. Ann Intern Med 141: 581-589.
8. Nickel JC, Downey J, Johnston B, Clark J, the Canadian Prostatitis Research Group (2001) Predictors of response to antibiotic therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective multicenter clinical study. J Urol 165: 1539-1544.
9. Nickel JC, Xiang J (2008) Clinical significance of non-traditional uropathogens in the management of chronic prostatitis. J Urol 179: 1391-1395.
10. Anothaisintawee T, Attia J, Nickel JC et al (2011) Management of chronic prostatitis/chronic pelvic pain syndrome: a systematic review and network meta-analysis. JAMA 305: 78-86.
11. Thakkinstian A, Attia J, Anothaisintawee T, Nickel JC (2012) Alpha-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). BJUI. 110: 1014-1022.
12. Ogino H, Fujii M, Ono M, Maezawa K, Hori S, Kizu J (2009) In vivo and in vitro effects of fluoroquinolones on lipopolysaccharide-induced pro-inflammatory cytokine production. J Infect Chemother 15: 168-173.
13. Tsivkovskii R, Sabet M, Tarazi Z, Griffith DC, Lomovskaya O, Dudley MN (2011) Levofloxacin reduces inflammatory cytokine levels in human bronchial epithelia cells: implications for aerosol MP-376 (levofloxacin solution for inhalation) treatment of chronic pulmonary infections. FEMS Immunol Med Microbiol 61: 141-146.
14. Cheah PY, Liong ML, Yuen KH et al (2003) Terazosin therapy for chronic prostatitis/chronic pelvic pain syndrome: a randomized, placebo controlled trial. J Urol 169: 592-596.
15. Chen Y, Wu X, Liu J, Tang W, Zhao T, Zhang J (2011) Effects of a 6-month course of tamsulosin for chronic prostatitis/chronic pelvic pain syndrome: a multicenter, randomized trial. World J Urol 29: 381-385.
16. Nickel JC, Narayan P, McKay J, Doyle C (2004) Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial. J Urol 171: 1594-1597.
17. Mehik A, Alas P, Nickel JC, Sarpola A, Helstrom PJ (2003) Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study. Urology 62: 425-429.
18. Nickel JC, Krieger JN, McNaughton-Collins M et al (2008) Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome. N Engl J Med 2008(359): 2663-2673.
19. Tugcu V, Tasci AI, Fazlioglu A et al (2007) A placebo-controlled comparison of the efficiency of triple- and monotherapy in category III B chronic pelvic pain syndrome (CPPS). Eur Urol 51: 1113.
20. Nickel JC, O'Leary MP, Lepor H et al (2011) Silodosin for men with chronic prostatitis/chronic pelvic pain syndrome: results of a Phase II multicenter, double-blind, placebo-controlled study. J Urol 186: 125-131.
21. Yang G, Wei Q, Li H, Yang Y, Zhang S, Dong Q (2006) The effect of alpha-adrenergic antagonists in chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis of randomized controlled trials. J Androl 27(6): 847-852.
22. Nickel JC, Pontari M, Moon T et al (2003) A randomized, placebo controlled, multicenter study to evaluate the safety and efficacy of rofecoxib in the treatment of chronic nonbacterial prostatitis. J Urol 169: 1401-1405.
23. Zhao WP, Zhang ZG, Li XD et al (2009) Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA). Braz J Med Biol Res 42: 963-967.
24. Nickel JC, Forrest JB, Tomera K et al (2005) Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study. J Urol 173: 1252-1255.
25. Goldmeier D, Madden P, McKenna M, Tamm N (2005) Treatment of category III A prostatitis with zafirlukast: a randomized controlled feasibility study. Int J STD AIDS 16: 196-200.
26. Bates SM, Hill VA, Anderson JB et al (2007) A prospective, randomized, double-blind trial to evaluate the role of a short reducing course of oral corticosteroid therapy in the treatment of chronic prostatitis/chronic pelvic pain syndrome. BJU Int 99: 355-359.
27. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54: 960-963.
28. Wagenlehner FM, Schneider H, Ludwig M, Schnitker J, Brahler E, Weidner W (2009) A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study. Eur Urol 56: 544-551.
29. Pontari MA, Krieger JN, Litwin MS et al (2010) Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. Arch Intern Med 170: 1586-1593.
30. Nickel JC, Downey J, Pontari MA, Shoskes DA, Zeitlin SI (2004) A randomized placebo-controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis). BJU Int 93: 991-995.
31. De Rose AF, Gallo F, Giglio M, Carmignani G (2004) Role of mepartricin in category III chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized prospective placebo-controlled trial. Urology 63: 13-16.
32. Nickel JC, Roehrborn C, Montorsi F, Wilson TH, Rittmaster RS (2011) Dutasteride reduces prostatitis symptoms compared with placebo in men enrolled in the REDUCE study. J Urol 186: 1313-1318.
33. FitzGerald MP, Anderson RU, Potts J et al (2009) Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes. J Urol 182: 570-580.
34. Zimmermann R, Cumpanas A, Miclea F et al (2009) Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome in males: a randomized, double-blind, placebo-controlled study. Eur Urol 56: 418.
35. Kabay S, Kabay SC, Yucel M, Ozden H (2009) Efficiency of posterior tibial nerve stimulation in category IIIB chronic prostatitis/chronic pelvic pain: a Sham-Controlled Comparative Study. Urol Int 83: 33-38.
36. Rowe E, Smith C, Laverick L, Elkabir J, Witherow RO, Patel A (2005) A prospective, randomized, placebo controlled, double-blind study of pelvic electromagnetic therapy for the treatment of chronic pelvic pain syndrome with 1 year of followup. J Urol 173: 2044-2047.
37. Lee SW, Liong ML, Yuen KH et al (2008) Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain. Am J Med 121: 79. e1-79. e7.
38. Lee SH, Lee BC (2009) Electroacupuncture relieves pain in men with chronic prostatitis/chronic pelvic pain syndrome: three-arm randomized trial. Urology 73: 1036-1041.
39. Anderson RU, Wise D, Sawyer T, Glowe P, Orenberg EK (2011) 6-day intensive treatment protocol for refractory chronic prostatitis/chronic pelvic pain syndrome using myofascial release and paradoxical relaxation training. J Urol 185: 1294-1299.
40. Leskinen MJ, Kilponen A, Lukkarinen O, Tammela TL (2002) Transurethral needle ablation for the treatment of chronic pelvic pain syndrome (category III prostatitis): a randomized, sham-controlled study. Urology 60: 300-304.
41. Nickel JC, Mullins C, Tripp DA (2008) Development of an evidence-based cognitive behavioral treatment program for men with chronic prostatitis/chronic pelvic pain syndrome. World J Urol 26: 167-172.
42. Nickel JC, Downey J, Ardern D, Clark J, Nickel K (2004) Failure of monotherapy strategy for the treatment of difficult chronic prostatitis/chronic pelvic pain syndrome patients. J Urol 172: 551-554.
43. Shoskes DA, Hakim L, Ghoniem G, Jackson CL (2003) Long-term results of multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome. J Urol 169: 1406-1410.
44. Shoskes DA, Nickel JC, Dolinga R, Prots D (2009) Clinical phenotyping of patients with chronic prostatitis/chronic pelvic pain syndrome and correlation with symptom severity. Urology 73: 538-542; discussion 542-3.
45. Nickel JC, Shoskes D (2010) Phenotypic approach to the management of the chronic prostatitis/chronic pelvic pain syndrome. BJU Int 106: 1252-1263.
46. Shoskes DA, Nickel JC, Kattan MW (2010) Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT. Urology 75: 1249-1253.
47. Shoskes DA, Nickel JC (2013) Classification and Treatment of Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome Using the UPOINT System. World J Urol. doi: 10. 1007/s00345-013-1075-6.
48. Nickel C, Atkinson G, Krieger J, Mills J, Pontari M, Shoskes D, Crook T (2012) Preliminary assessment of safety and efficacy in a proof-of-concept, randomized clinical trial of tanezumab for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Urology 80: 1105-1110.