A randomized placebo-controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis)

BJU International

Volumn 93, Issue 7, 2004, Pages 991-995

  Nickel, J C ^a,e   Downey, J ^a   Pontari, M A ^b   Shoskes, D A ^c   Zeitlin, S I ^d  

^a QUEEN S UNIVERSITY   (Canada)

^b TEMPLE UNIVERSITY   (United States)

^c DEPARTMENT OF COLORECTAL SURGERY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

5 reductase inhibitors; Chronic nonbacterial prostatitis; Chronic pelvic pain syndrome; Finasteride; Prostatitis

Indexed keywords

FINASTERIDE; ENZYME INHIBITOR;

ACNE; ADULT; CHRONIC PROSTATITIS; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EJACULATION; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; LIBIDO DISORDER; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; MULTICENTER STUDY; PELVIS PAIN SYNDROME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SIDE EFFECT; THROAT DISEASE; TREATMENT OUTCOME; WEIGHT GAIN; XEROSTOMIA; AGED; ARTICLE; CHRONIC DISEASE; MIDDLE AGED; PILOT STUDY; PROSTATITIS;

ADULT; AGED; CHRONIC DISEASE; ENZYME INHIBITORS; FINASTERIDE; HUMANS; MALE; MIDDLE AGED; PELVIC PAIN; PILOT PROJECTS; PROSTATITIS; TREATMENT OUTCOME;

EID: 2542531485     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2003.04766.x     Document Type: Conference Paper

References (30)

1. McNaughton-Collins M, MacDonald R, Wilt TJ. Diagnosis and treatment of chronic abacterial prostatitis: a systematic review. Ann Intern Med 2000; 133: 367-81
2. Bjerklund Johansen T, Gruneberg RN, Guibert J et al. The role of antibiotics in the treatment of chronic prostatitis: a consensus statement. Eur Urol 1998; 34: 457-66
3. Nickel JC, Downey J, Clark J et al. Levofloxacin treatment for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo controlled multicenter trial. Urology 2003; 62: 614-7
4. Nickel JC, Narayan P, McKay J, Doyle C. Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double-blind trial. J Urol 2004; 171: 1594-7
5. Cheah PY, Liong ML, Yuen KH et al. Terazosin therapy for chronic prostatitis/chronic pelvic pain syndrome: a randomized, placebo controlled trial. J Urol 2003; 169: 592-6
6. Mehik A, Alas P, Nickel JC, Sarpola A, Helstrom PJ. Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: A prospective, randomized, double-blind, placebo-controlled, pilot study. Urology 2003; 62: 425-9
7. Nickel JC, Pontari M, Moon T et al. A randomized, placebo controlled, multicenter study to evaluate the safety and efficacy of rofecoxib in the treatment of chronic nonbacterial prostatitis. J Urol 2003; 169: 1401-5
8. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo control trial. Urology 1999; 54: 960-3
9. Nickel JC, Forrest J, Tomera KM et al. Effects of pentosan polysulfate sodium in men with chronic pelvic pain syndrome: a multi-center randomized, placebo-controlled study. J Urol 2002; 167 (Suppl.): 63, A248
10. Propert KJ, Alexander RB, Nickel JC, Kusek JW, Litwin MS. The design of a multi-center randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome. Urology 2002; 59: 870-6
11. McConnel JD, Wilson JD, George FW, Geller J, Pappas F, Stoner E. Finasteride, an inhibitor of 5-alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab 1992; 74: 505-8
12. Evans DTP. Medical management of chronic nonbacterial prostatitis. In Nickel JC ed. Prostatitis. Oxford: Isis Medical Media Inc, 1999: 293-309
13. Holm M, Meyhoff HH. Chronic prostatic pain; a new treatment option with finasteride? Scand J Urol Nephrol 1996; 31: 213-5
14. Golio G. The use of finasteride in the treatment of chronic nonbacterial prostatitis. In Abstracts of the 49th Annual Meeting of the Northeastern Section of the AUA. Litchfield, Arizona: October 23-26, 1997: 128
15. Leskinen M, Lukkarinen O, Marttilla T. Effects of finasteride in patients with inflammatory chronic pelvic pain syndrome: a double-blind, placebo controlled, pilot study. Urology 1999; 53: 502-5
16. Krieger JN, Nyberg LJ, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA 1999; 282: 236-7
17. Nickel JC, Nyberg LM, Hennenfent M. Research guidelines for chronic prostatitis, consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology 1999; 54: 229-33
18. Meares EM Jr, Stamey TA. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol 1968; 5: 492-518
19. Krieger JN, Jacobs R, Ross SO. Does the chronic prostatitis/pelvic pain syndrome differ from non-bacterial prostatitis and prostatodynia? J Urol 2000; 64: 1554-8
20. Nickel JC, Sorensen R. Transurethral microwave thermotherapy for nonbacterial prostatitis: a randomized double blind sham controlled study using new prostatitis specific assessment questionnaires. J Urol 1996; 155: 1950-5
21. Chen R, Nickel JC. Acupuncture ameliorates symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. Urology 2003; 61: 1156-9
22. Litwin MS, McNaughton-Collins M, Fowler FJ Jr et al. The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. J Urol 1999; 162: 369-75
23. Pareek G, Shevchuk M, Armenakas NA, Vasjovic L, Hochberg DA, Basillote JB. The effect of finasteride on the expression of vascular endothelial growth factor and microvessel density: a possible mechanism for decreased prostatic bleeding in treated patients. J Urol 2003; 169: 20-3
24. Nickel JC. The role of the animal model in the study of prostatitis. In Bergan T ed. Urinary Tract Infection. Basel: Karger, 1997: 89-97
25. Kirby RS, Lowe D, Bultitude MI, Shuttleworth KE. Intraprostatic urinary reflux: An aetiological factor in abacterial prostatitis. Br J Urol 1982; 54: 729-31
26. Mehik A, Hellstrom P, Nickel JC et al. Chronic prostatitis/chronic pelvic pain syndrome can be characterized by prostatic tissue pressure measurements. J Urol 2001; 167: 137-40
27. Nickel JC, True LD, Kreiger JN, Berger RE, Baog AH, Young ID. Consensus development of a histopathological classification system for chronic prostatic inflammation. Br J Urol Int 2001; 87: 797-805
28. Thompson IM, Goodman PJ, Tangen CM et al. The influence of finasteride on the development of prostate cancer. NEJM 2003; 349: 213-22
29. Kaplan SA, Volpe MA, Te AE. A prospective, 1-year trial using saw palmetto versus finasteride in the treatment of category III prostatitis/chronic pelvic pain syndrome. J Urol 2004; 171: 284-8
30. McConnell JD, Roehrborn CG, Bautista OM et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. NEJM 2003; 349: 2387-98