Acute high-altitude exposure reduces lung diffusion: Data from the HIGHCARE Alps project

Respiratory Physiology and Neurobiology

Volumn 188, Issue 2, 2013, Pages 223-228

  Agostoni, Piergiuseppe ^a,b,c   Swenson, Erik R ^b   Fumagalli, Roberto ^d   Salvioni, Elisabetta ^a   Cattadori, Gaia ^a   Farina, Stefania ^a   Bussotti, Maurizio ^e   Tamplenizza, Margherita ^f   Lombardi, Carolina ^g,h   Bonacina, Daniele ^d   Brioschi, Maura ^a   Caravita, Sergio ^g   Modesti, Pietro ^i,j   Revera, Miriam ^g,h   Giuliano, Andrea ^g   Meriggi, Paolo ^j   Faini, Andrea ^g   Bilo, Grzegorz ^g   Banfi, Cristina ^a   Parati, Gianfranco ^g,h  

^a CENTRO CARDIOLOGICO MONZINO   (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Department of Clinical Sciences and Community Health ^*  (Italy)

^d SAN GERARDO HOSPITAL   (Italy)

^e IRCCS   (Italy)

^f UNIVERSITY OF MILAN   (Italy)

^g ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^h UNIVERSITY OF MILANO BICOCCA   (Italy)

ⁱ UNIVERSITY OF FLORENCE   (Italy)

^j IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

more..

Author keywords

Gas exchange; Hypoxia; Pulmonary edema; Surfactant derived proteins

Indexed keywords

ACETAZOLAMIDE; ADVANCED GLYCATION END PRODUCT RECEPTOR; CARBON MONOXIDE; HEMOGLOBIN; OXYGEN; PLACEBO; SURFACTANT PROTEIN B;

ACUTE HIGH ALTITUDE EXPOSURE; ADULT; ALTITUDE ACCLIMATIZATION; ALVEOLAR CAPILLARY MEMBRANE DAMAGE; ARTICLE; CAPILLARY WALL; DIFFUSION; ECHOGRAPHY; FEMALE; HUMAN; HYPOBARISM; HYPOXIA; ITALY; LUNG ALVEOLUS; LUNG CAPILLARY; LUNG DIFFUSION; LUNG EXTRAVASCULAR FLUID; LUNG FLUID; LUNG GAS EXCHANGE; LUNG VOLUME; MALE; MEMBRANE DAMAGE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SEA LEVEL;

EID: 84881029691     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2013.04.005     Document Type: Article

References (40)

1. Agostoni P., Banfi C., Brioschi M., Magri D., Sciomer S., Berna G., Brambillasca C., Marenzi G., Sisillo E. Surfactant protein B and RAGE increases in the plasma during cardiopulmonary bypass: a pilot study. European Respiratory Journal 2011, 37:841-847.
2. Agostoni P., Banfi C., Magri D., Vignati C., Doria E., Salvioni E., Moliterni P., Marenzi G., Tremoli E., Sisillo E. Kinetics of plasma SPB and RAGE during mechanical ventilation in patients undergoing major vascular surgery. Respiratory Physiology and Neurobiology 2011, 178:256-260.
3. 2 saturation after acute but not prolonged altitude exposure. European Heart Journal 2009, 31:457-463.
4. Agostoni P., Cattadori G., Bianchi M., Wasserman K. Exercise-induced pulmonary edema in heart failure. Circulation 2003, 108:2666-2671.
5. Agostoni P., Swenson E.R., Bussotti M., Revera M., Meriggi P., Faini A., Lombardi C., Bilo G., Giuliano A., Bonacina D., Modesti P.A., Mancia G., Parati G. High-altitude exposure of three weeks duration increases lung diffusing capacity in humans. Journal of Applied Physiology 2011, 110:1564-1571.
6. Anholm J.D., Milne E.N., Stark P., Bourne J.C., Friedman P. Radiographic evidence of interstitial pulmonary edema after exercise at altitude. Journal of Applied Physiology 1999, 86:503-509.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
8. Cattadori G., Wasserman K., Meloni C., Mustaq S., Contini M., Apostolo A., Andreini D., Magri D., Sciomer S., Veglia F., Berna G., Introcaso G., Palermo P., Fiorentini C., Agostoni P. Alveolar membrane conductance decreases as BNP increases during exercise in heart failure. Rationale for BNP in the evaluation of dyspnea. Journal of Cardiac Failure 2009, 15:136-144.
9. Cerny F.C., Dempsey J.A., Reddan W.G. Pulmonary gas exchange in nonnative residents of high altitude. Journal of Clinical Investigation 1973, 52:2993-2999.
10. Cogo A., Miserocchi G. Pro: most climbers develop subclinical pulmonary interstitial edema. High Altitude Medicine and Biology 2011, 12:121-124. (discussion 131-122).
11. Cremona G., Asnaghi R., Baderna P., Brunetto A., Brutsaert T., Cavallaro C., Clark T.M., Cogo A., Donis R., Lanfranchi P., Luks A., Novello N., Panzetta S., Perini L., Putnam M., Spagnolatti L., Wagner H., Wagner P.D. Pulmonary extravascular fluid accumulation in recreational climbers: a prospective study. Lancet 2002, 359:303-309.
12. de Bisschop C., Kiger L., Marden M.C., Ajata A., Huez S., Faoro V., Martinot J.B., Naeije R., Guenard H. Pulmonary capillary blood volume and membrane conductance in Andeans and lowlanders at high altitude: a cross-sectional study. Nitric Oxide 2010, 23:187-193.
13. de Bisschop C., Martinot J.B., Leurquin-Sterk G., Faoro V., Guenard H., Naeije R. Improvement in lung diffusion by endothelin a receptor blockade at high altitude. Journal of Applied Physiology 2012, 112(1):20-25.
14. de Pasquale C.G., Arnolda L.F., Doyle I.R., Aylward P.E., Chew D.P., Bersten A.D. Plasma surfactant protein-B: a novel biomarker in chronic heart failure. Circulation 2004, 110:1091-1096.
15. Dehnert C., Luks A.M., Schendler G., Menold E., Berger M.M., Mairbaurl H., Faoro V., Bailey D.M., Castell C., Hahn G., Vock P., Swenson E.R., Bartsch P. No evidence for interstitial lung oedema by extensive pulmonary function testing at 4559m. European Respiratory Journal 2010, 35:812-820.
16. Ge R.L., Matsuzawa Y., Takeoka M., Kubo K., Sekiguchi M., Kobayashi T. Low pulmonary diffusing capacity in subjects with acute mountain sickness. Chest 1997, 111:58-64.
17. Grissom C.K., Roach R.C., Sarnquist F.H., Hackett P.H. Acetazolamide in the treatment of acute mountain sickness: clinical efficacy and effect on gas exchange. Annals of Internal Medicine 1992, 116:461-465.
18. Groepenhoff H., Overbeek M.J., Mule M., van der Plas M., Argiento P., Villafuerte F.C., Beloka S., Faoro V., Macarlupu J.L., Guenard H., de Bisschop C., Martinot J.B., Vanderpool R., Penaloza D., Naeije R. Exercise pathophysiology in patients with chronic mountain sickness. Chest 2012, 142(4):877-884.
19. Hopkins S.R., Schoene R.B., Henderson W.R., Spragg R.G., Martin T.R., West J.B. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. American Journal of Respiratory and Critical Care Medicine 1997, 155:1090-1094.
20. Hsia C.C., Johnson R.L., McDonough P., Dane D.M., Hurst M.D., Fehmel J.L., Wagner H.E., Wagner P.D. Residence at 3800-m altitude for 5 mo in growing dogs enhances lung diffusing capacity for oxygen that persists at least 2.5 years. Journal of Applied Physiology 2007, 102:1448-1455.
21. Kishore U., Greenhough T.J., Waters P., Shrive A.K., Ghai R., Kamran M.F., Bernal A.L., Reid K.B., Madan T., Chakraborty T. Surfactant proteins SP-A and SP-D: structure, function and receptors. Molecular Immunology 2006, 43:1293-1315.
22. Larsson K., Ohlsen P., Larsson L., Malmberg P., Rydstrom P.O., Ulriksen H. High prevalence of asthma in cross country skiers. BMJ 1993, 307:1326-1329.
23. Macintyre N., Crapo R.O., Viegi G., Johnson D.C., van der Grinten C.P., Brusasco V., Burgos F., Casaburi R., Coates A., Enright P., Gustafsson P., Hankinson J., Jensen R., McKay R., Miller M.R., Navajas D., Pedersen O.F., Pellegrino R., Wanger J. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. European Respiratory Journal 2005, 26:720-735.
24. Magri D., Brioschi M., Banfi C., Schmid J.P., Palermo P., Contini M., Apostolo A., Bussotti M., Tremoli E., Sciomer S., Cattadori G., Fiorentini C., Agostoni P. Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure. Circulation: Heart Failure 2009, 2:175-180.
25. Mutlu G.M., Koch W.J., Factor P. Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport. American Journal of Respiratory and Critical Care Medicine 2004, 170:1270-1275.
26. Pellegrino R., Pompilio P., Quaranta M., Aliverti A., Kayser B., Miserocchi G., Fasano V., Cogo A., Milanese M., Cornara G., Brusasco V., Dellaca R. Airway responses to methacholine and exercise at high altitude in healthy lowlanders. Journal of Applied Physiology 2010, 108:256-265.
27. Picano E., Frassi F., Agricola E., Gligorova S., Gargani L., Mottola G. Ultrasound lung comets: a clinically useful sign of extravascular lung water. Journal of the American Society of Echocardiography 2006, 19:356-363.
28. Pratali L., Cavana M., Sicari R., Picano E. Frequent subclinical high-altitude pulmonary edema detected by chest sonography as ultrasound lung comets in recreational climbers. Critical Care Medicine 2010, 38:1818-1823.
29. Ramage J.E., Coleman R.E., MacIntyre N.R. Rest and exercise cardiac output and diffusing capacity assessed by a single slow exhalation of methane, acetylene and carbon monoxide. Chest 1987, 92:44-50.
30. Roach R.C., Bartsch P., Hackett P.H., Oelz O. The lake Louise score acute mountain sickness scoring system. Hypoxia and Molecular Medicine: Proceedings of the 8th International Hypoxia Symposium, Lake Louise Alberta, Canada 1993, 272-274. Queen City Printers, Burlinghton Vt. J.R. Sutton, C.G.G.S. Houston (Eds.).
31. Robertson H.T., Pellegrino R., Pini D., Oreglia J., DeVita S., Brusasco V., Agostoni P. Exercise response after rapid intravenous infusion of saline in healthy humans. Journal of Applied Physiology 2004, 97:697-703.
32. Roughton F.J., Forster R.E. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. Journal of Applied Physiology 1957, 11:290-302.
33. Schmidt A.M., Yan S.D., Yan S.F., Stern D.M. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. Journal of Clinical Investigation 2001, 108:949-955.
34. Swenson E.R. Con: most climbers do not develop subclinical interstitial pulmonary edema. High Altitude Medicine and Biology 2011, 12:125-128. (discussion 129-130).
35. Swenson E.R., Maggiorini M., Mongovin S., Gibbs J.S., Greve I., Mairbaurl H., Bartsch P. Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. JAMA 2002, 287:2228-2235.
36. Swenson E.R., Teppema L.J. Prevention of acute mountain sickness by acetazolamide: as yet an unfinished story. Journal of Applied Physiology 2007, 102:1305-1307.
37. Weiskopf R.B., Severinghaus J.W. Diffusing capacity of the lung for CO in man during acute acclimation to 14,246ft. Journal of Applied Physiology 1972, 32:285-289.
38. Wilber R.L., Rundell K.W., Szmedra L., Jenkinson D.M., Im J., Drake S.D. Incidence of exercise-induced bronchospasm in Olympic winter sport athletes. Medicine and Science in Sports and Exercise 2000, 32:732-737.
39. Wu T., Kayser B. High altitude adaptation in Tibetans. High Altitude Medicine and Biology 2006, 7:193-208.
40. Yilmaz C., Dane D.M., Hsia C.C. Alveolar diffusion-perfusion interactions during high-altitude residence in guinea pigs. Journal of Applied Physiology 2007, 102:2179-2185.