The role of intracellular high-mobility group box 1 in the early activation of Kupffer cells and the development of Con A-induced acute liver failure

Immunobiology

Volumn 218, Issue 10, 2013, Pages 1284-1292

  Yang, Qiao ^a   Liu, Yanning ^a   Shi, Yu ^a   Zheng, Min ^a   He, Jiliang ^b   Chen, Zhi ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Acute liver failure; Apoptosis; High mobility group box 1; Inflammation; Kupffer cells

Indexed keywords

CONCANAVALIN A; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOFLUORESCENCE; KUPFFER CELL; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

4′,6-DIAMIDINO-2-PHENYLINDOLE; ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE; ALF; ALT; ANALYSIS OF VARIANCE; ANOVA; APOPTOSIS; ASPARTATE AMINOTRANSFERASE; AST; BOVINE SERUM ALBUMIN; BSA; CON A; CONCANAVALIN A; DAPI; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HIGH-MOBILITY GROUP BOX 1; HMGB1; IL; INFLAMMATION; INTERLEUKIN; KC; KUPFFER CELL; KUPFFER CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II; MAPK; MHC II; MITOGEN-ACTIVATED PROTEIN KINASE; MNC; MONONUCLEAR CELL; PBS; PHOSPHATE-BUFFERED SALINE; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RIBONUCLEIC ACID; RNA; RT-PCR; SD; SDS-PAGE; SIRNA; SMALL INTERFERING RIBONUCLEIC ACID; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS; STANDARD DEVIATION; TBST; TNF-Α; TRIS-BUFFERED SALINE TWEEN-20; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALS; CELL NUCLEUS; CONCANAVALIN A; CYTOKINES; DISEASE MODELS, ANIMAL; HMGB1 PROTEIN; HUMANS; INFLAMMATION MEDIATORS; KUPFFER CELLS; LIVER FAILURE, ACUTE; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84881024399     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2013.04.011     Document Type: Article

References (30)

1. Andersson U., Tracey K.J. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 2011, 29:139-162.
2. Andersson U., Wang H., Palmblad K., Aveberger A.C., Bloom O., Erlandsson-Harris H., Janson A., Kokkola R., Zhang M., Yang H., Tracey K.J. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J. Exp. Med. 2000, 192:565-570.
3. Antoniades C.G., Berry P.A., Davies E.T., Hussain M., Bernal W., Vergani D., Wendon J. Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure. Hepatology 2006, 44:34-43.
4. Antoniades C.G., Berry P.A., Wendon J.A., Vergani D. The importance of immune dysfunction in determining outcome in acute liver failure. J. Hepatol. 2008, 49:845-861.
5. Biswas S.K., Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 2010, 11:889-896.
6. Chakraborty R., Bhatt K.H., Sodhi A. Ultraviolet B induces high mobility group box 1 release from mouse peritoneal macrophages in vitro via caspase-1 mediated secretion pathway. Immunobiology 2012, (Ahead of Print).
7. Chen F., Zhu H.H., Zhou L.F., Li J., Zhao L.Y., Wu S.S., Wang J., Liu W., Chen Z. Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model. BMC Genomics 2010, 11:240.
8. Jung J.H., Park J.H., Jee M.H., Keum S.J., Cho M.S., Yoon S.K., Jang S.K. Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells. J. Virol. 2011, 85:9359-9368.
9. Klune J.R., Dhupar R., Cardinal J., Billiar T.R., Tsung A. HMGB1: endogenous danger signaling. Mol. Med. 2008, 14:476-484.
10. Laskin D.L. Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem. Res. Toxicol. 2006, 22:1376-1385.
11. Li J., Chen F., Zheng M., Zhu H., Zhao D., Liu W., Liu W., Chen Z. Inhibition of STAT1 methylation is involved in the resistance of hepatitis B virus to interferon alpha. Antiviral Res. 2010, 85:463-469.
12. Li L., Chen L., Hu L., Liu Y., Sun H.Y., Tang J., Hou Y.J., Chang Y.X., Tu Q.Q., Feng G.S., Shen F., Wu M.C., Wang H.Y. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology 2011, 54:1620-1630.
13. Liu C., Tao Q., Sun M., Wu J.Z., Yang W., Jian P., Peng J., Hu Y., Liu C., Liu P. Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. Lab. Invest. 2010, 90:1805-1816.
14. Liu W.X., Zhu H.H., Wu W., He J.L., Chen Z. Inhibition effect produced by dominant negative mutant fusion protein PreS2-TLM-ScFv-HBcDN on HBV replication in vitro. J. Viral Hepat. 2012, 19:295-300.
15. Malik R., Mookerjee R.P., Jalan R. Infection and inflammation in liver failure: two sides of the same coin. J. Hepatol. 2009, 51:426-429.
16. Nakao A., Taki S., Yasui M., Kimura Y., Nonami T., Harada A., Takagi H. The fate of intravenously injected endotoxin in normal rats and in rats with liver failure. Hepatology 1994, 19:1251-1256.
17. Nakashima H., Kinoshita M., Nakashima M., Habu Y., Shono S., Uchida T., Shinomiya N., Seki S. Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice. Hepatology 2008, 48:1979-1988.
18. Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells. Hepatology 2006, 44:1487-1501.
19. Park J.S., Svetkauskaite D., He Q., Kim J.Y., Strassheim D., Ishizaka A., Abraham E. Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 2004, 279:7370-7377.
20. Riordan S.M., Williams R. Acute liver failure: targeted artificial and hepatocyte-based support of liver regeneration and reversal of multiorgan failure. J. Hepatol. 2000, 32:63-76.
21. Rolando N., Wade J., Davalos M., Wendon J., Philpott-Howard J., Williams R. The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000, 32:734-739.
22. Schmitz K.J., Wohlschlaeger J., Lang H., Sotiropoulos G.C., Malago M., Steveling K., Reis H., Cicinnati V.R., Schmid K.W., Baba H.A. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J. Hepatol. 2008, 48:83-90.
23. Serti E., Doumba P.P., Thyphronitis G., Tsitoura P., Katsarou K., Foka P., Konstandoulakis M.M., Koskinas J., Mavromara P., Georgopoulou U. Modulation of IL-2 expression after uptake of hepatitis C virus non-enveloped capsid-like particles: the role of p38 kinase. Cell. Mol. Life Sci. 2011, 68:505-522.
24. Tiegs G., Hentschel J., Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 1992, 90:196-203.
25. Tsung A., Sahai R., Tanaka H., Nakao A., Fink M.P., Lotze M.T., Yang H., Li J., Tracey K.J., Geller D.A., Billiar T.R. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 2005, 201:1135-1143.
26. van der Bij G.J., Oosterling S.J., Meijer S., Beelen R.H., van.Egmond M. Therapeutic potential of Kupffer cells in prevention of liver metastases outgrowth. Immunobiology 2005, 210:259-265.
27. Yan W., Chang Y., Liang X., Cardinal J.S., Huang H., Thorne S.H., Monga S.P., Geller D.A., Lotze M.T., Tsung A. High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases. Hepatology 2012, 55:1863-1875.
28. Yang Q., Shi Y., He J., Chen Z. The evolving story of macrophages in acute liver failure. Immunol. Lett. 2012, 147:1-9.
29. Zhou R.R., Zhao S.S., Zou M.X., Zhang P., Zhang B.X., Dai X.H., Li N., Liu H.B., Wang H., Fan X.G. HMGB1 cytoplasmic translocation in patients with acute liver failure. BMC Gastroenterol. 2011, 11:21.
30. Zouali M. The epigenetics of autoimmune diseases. Post-translational Modification of HMGB1 and its Role in Immune Activation 2009, 165-174. Wiley-Blackwell, West Sussex. J.U. Anirudh, S.P. David (Eds.).