The Streptococcus mutans aminotransferase encoded by ilvE is regulated by CodY and CcpA

Journal of Bacteriology

Volumn 195, Issue 16, 2013, Pages 3552-3562

  Santiago, Brendaliz ^a   Marek, Maksym ^a   Faustoferri, Roberta C ^a   Quivey, Robert G ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; AMINOTRANSFERASE; BRANCHED CHAIN AMINO ACID; CARBON; CODY PROTEIN; ILVE PROTEIN; UNCLASSIFIED DRUG;

ACIDITY; AMINO ACID SYNTHESIS; ARTICLE; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STREPTOCOCCUS MUTANS;

EID: 84880985618     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00394-13     Document Type: Article

References (45)

1. Fozo EM, Quivey RG, Jr. 2004. Shifts in the membrane fatty acid profile of Streptococcus mutans enhance survival in acidic environments. Appl. Environ. Microbiol. 70:929-936.
2. Griswold AR, Jameson-Lee M, Burne RA. 2006. Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159. J. Bacteriol. 188:834-841.
3. Kuhnert WL, Zheng G, Faustoferri RC, Quivey RG, Jr. 2004. The F-ATPase operon promoter of Streptococcus mutans is transcriptionally regulated in response to external pH. J. Bacteriol. 186:8524-8528.
4. Quivey RG, Jr, Kuhnert WL, Hahn K. 2000. Adaptation of oral streptococci to low pH. Adv. Microb. Physiol. 42:239-274.
5. Matsui R, Cvitkovitch D. 2010. Acid tolerance mechanisms utilized by Streptococcus mutans. Future Microbiol. 5:403-417.
6. Chia JS, Lee YY, Huang PT, Chen JY. 2001. Identification of stressresponsive genes in Streptococcus mutans by differential display reverse transcription-PCR. Infect. Immun. 69:2493-2501.
7. Len AC, Harty DW, Jacques NA. 2004. Proteome analysis of Streptococcus mutans metabolic phenotype during acid tolerance. Microbiology 150: 1353-1366.
8. Sonenshein AL. 2007. Control of key metabolic intersections in Bacillus subtilis. Nat. Rev. Microbiol. 5:917-927.
9. Bennett HJ, Pearce DM, Glenn S, Taylor CM, Kuhn M, Sonenshein AL, Andrew PW, Roberts IS. 2007. Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence. Mol. Microbiol. 63:1453-1467.
10. Dineen SS, McBride SM, Sonenshein AL. 2010. Integration of metabolism and virulence by Clostridium difficile CodY. J. Bacteriol. 192:5350-5362.
11. Hendriksen WT, Bootsma HJ, Estevao S, Hoogenboezem T, de Jong A, de Groot R, Kuipers OP, Hermans PW. 2008. CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization. J. Bacteriol. 190:590-601.
12. Serror P, Sonenshein AL. 1996. Interaction of CodY, a novel Bacillus subtilis DNA-binding protein, with the dpp promoter region. Mol. Microbiol. 20:843-852.
13. Slack FJ, Serror P, Joyce E, Sonenshein AL. 1995. A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon. Mol. Microbiol. 15:689-702.
14. Sonenshein AL. 2005. CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria. Curr. Opin. Microbiol. 8:203-207.
15. Molle V, Nakaura Y, Shivers RP, Yamaguchi H, Losick R, Fujita Y, Sonenshein AL. 2003. Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. J. Bacteriol. 185:1911-1922.
16. Shivers RP, Sonenshein AL. 2005. Bacillus subtilis ilvB operon: an intersection of global regulons. Mol. Microbiol. 56:1549-1559.
17. Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, Somerville GA, Bodi K, Sonenshein AL. 2010. Direct targets of CodY in Staphylococcus aureus. J. Bacteriol. 192:2861-2877.
18. Villapakkam AC, Handke LD, Belitsky BR, Levdikov VM, Wilkinson AJ, Sonenshein AL. 2009. Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids. J. Bacteriol. 191:6865-6876.
19. Den Hengst CD, van Hijum SA, Geurts JM, Nauta A, Kok J, Kuipers OP. 2005. The Lactococcus lactis CodY regulon: identification of a conserved cis-regulatory element. J. Biol. Chem. 280:34332-34342.
20. Lemos JA, Nascimento MM, Lin VK, Abranches J, Burne RA. 2008. Global regulation by (p)ppGpp and CodY in Streptococcus mutans. J. Bacteriol. 190:5291-5299.
21. Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL. 2010. Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools. J. Bacteriol. 192:6357-6368.
22. Chambellon E, Yvon M. 2003. CodY-regulated aminotransferases AraT and BcaT play a major role in the growth of Lactococcus lactis in milk by regulating the intracellular pool of amino acids. Appl. Environ. Microbiol. 69:3061-3068.
23. Tojo S, Satomura T, Morisaki K, Deutscher J, Hirooka K, Fujita Y. 2005. Elaborate transcription regulation of the Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids through global regulators of CcpA, CodY and TnrA. Mol. Microbiol. 56: 1560-1573.
24. Henkin TM. 1996. The role of CcpA transcriptional regulator in carbon metabolism in Bacillus subtilis. FEMS Microbiol. Lett. 135:9-15.
25. Abranches J, Nascimento MM, Zeng L, Browngardt CM, Wen ZT, Rivera MF, Burne RA. 2008. CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans. J. Bacteriol. 190:2340-2349.
26. Ludwig H, Meinken C, Matin A, Stulke J. 2002. Insufficient expression of the ilv-leu operon encoding enzymes of branched-chain amino acid biosynthesis limits growth of a Bacillus subtilis ccpA mutant. J. Bacteriol. 184:5174-5178.
27. Commichau FM, Forchhammer K, Stulke J. 2006. Regulatory links between carbon and nitrogen metabolism. Curr. Opin. Microbiol. 9:167-172.
28. Santiago B, MacGilvray M, Faustoferri RC, Quivey RG, Jr. 2012. The branched-chain amino acid aminotransferase encoded by ilvE is involved in acid tolerance in Streptococcus mutans. J. Bacteriol. 194:2010-2019.
29. Guedon E, Sperandio B, Pons N, Ehrlich SD, Renault P. 2005. Overall control of nitrogen metabolism in Lactococcus lactis by CodY, and possible models for CodY regulation in Firmicutes. Microbiology 151:3895-3909.
30. Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ. 2002. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc. Natl. Acad. Sci. U. S. A. 99:14434-14439.
31. Murchison HH, Barrett JF, Cardineau GA, Curtiss R, 3rd. 1986. Transformation of Streptococcus mutans with chromosomal and shuttle plasmid (pYA629) DNAs. Infect. Immun. 54:273-282.
32. Aslanidis C, de Jong PJ. 1990. Ligation-independent cloning of PCR products (LIC-PCR). Nucleic Acids Res. 18:6069-6074.
33. Lau PC, Sung CK, Lee JH, Morrison DA, Cvitkovitch DG. 2002. PCR ligation mutagenesis in transformable streptococci: application and efficiency. J. Microbiol. Methods 49:193-205.
34. Sheng J, Marquis RE. 2007. Malolactic fermentation by Streptococcus mutans. FEMS Microbiol. Lett. 272:196-201.
35. Derr AM, Faustoferri RC, Betzenhauser MJ, Gonzalez K, Marquis RE, Quivey RG, Jr. 2012. Mutation of the NADH oxidase gene (nox) reveals an overlap of the oxygen-and acid-mediated stress responses in Streptococcus mutans. Appl. Environ. Microbiol. 78:1215-1227.
36. Terleckyj B, Willett NP, Shockman GD. 1975. Growth of several cariogenic strains of oral streptococci in a chemically defined medium. Infect. Immun. 11:649-655.
37. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
38. Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL. 2001. Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes Dev. 15:1093-1103.
39. Shaw WV, Hopwood DA. 1976. Chloramphenicol acetylation in Streptomyces. J. Gen. Microbiol. 94:159-166.
40. Jerga A, Rock CO. 2009. Acyl-acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae. J. Biol. Chem. 284:15364-15368.
41. Handke LD, Shivers RP, Sonenshein AL. 2008. Interaction of Bacillus subtilis CodY with GTP. J. Bacteriol. 190:798-806.
42. Majerczyk CD, Sadykov MR, Luong TT, Lee C, Somerville GA, Sonenshein AL. 2008. Staphylococcus aureus CodY negatively regulates virulence gene expression. J. Bacteriol. 190:2257-2265.
43. Madsen SM, Beck HC, Ravn P, Vrang A, Hansen AM, Israelsen H. 2002. Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme. Appl. Environ. Microbiol. 68:4007-4014.
44. Terleckyj B, Shockman GD. 1975. Amino acid requirements of Streptococcus mutans and other oral streptococci. Infect. Immun. 11:656-664.
45. Wunsche A, Hammer E, Bartholomae M, Volker U, Burkovski A, Seidel G, Hillen W. 2012. CcpA forms complexes with CodY and RpoA in Bacillus subtilis. FEBS J. 279:2201-2214.