Placental HTR2A methylation is associated with infant neurobehavioral outcomes

Epigenetics

Volumn 8, Issue 8, 2013, Pages 796-801

  Paquette, Alison G ^a   Lesseur, Corina ^a   Armstrong, David A ^a   Koestler, Devin C ^a   Appleton, Allison A ^a   Lester, Barry M ^b   Marsit, Carmen J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Behavior; Developmental origins of disease; DNA methylation; Epigenetic; HTR2A; Neurodevelopment; Placenta; Serotonin

Indexed keywords

SEROTONIN 2A RECEPTOR;

ADULT; ALCOHOL CONSUMPTION; ANXIETY; ARTICLE; ATTENTION; CONTROLLED STUDY; CPG ISLAND; DEPRESSION; DNA METHYLATION; FEMALE; GENDER; GENETIC POLYMORPHISM; GESTATIONAL AGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MOVEMENT (PHYSIOLOGY); NEUROPHYSIOLOGY; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PREGNANCY OUTCOME; PROTEIN EXPRESSION; PYROSEQUENCING; SCORING SYSTEM; SMOKING; TOBACCO DEPENDENCE;

NICOTIANA TABACUM;

BEHAVIOR; DEVELOPMENTAL ORIGINS OF DISEASE; DNA METHYLATION; EPIGENETIC; HTR2A; NEURODEVELOPMENT; PLACENTA; SEROTONIN;

CHILD DEVELOPMENT; DNA METHYLATION; FEMALE; HUMANS; INFANT BEHAVIOR; INFANT, NEWBORN; MALE; NICOTINE; PLACENTA; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROMOTER REGIONS, GENETIC; RECEPTOR, SEROTONIN, 5-HT2A; SEX FACTORS;

EID: 84880974083     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.25358     Document Type: Article

References (34)

1. Sandman CA, Davis EP, Buss C, Glynn LM. Prenatal programming of human neurological function. Int J Pept 2011; 2011:837596; PMID:21760821; http:// dx.doi.org/10.1155/2011/837596
2. Millan MJ. An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy. Neuropharmacology 2013; 68:2-82; PMID:23246909
3. Coyle MG, Salisbury AL, Lester BM, Jones HE, Lin H, Graf-Rohrmeister K, et al. Neonatal neurobehavior effects following buprenorphine versus methadone exposure. Addiction 2012; 107(Suppl 1):63-73; PMID:23106928; http://dx.doi.org/10.1111/j.1360-0443.2012.04040.x
4. Welberg LA, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol 2001; 13:113-28; PMID:11168837; http://dx.doi. org/10.1111/j.1365-2826.2001.00601.x
5. Sandman CA, Davis EP. Neurobehavioral risk is associated with gestational exposure to stress hormones. Expert Rev Endocrinol Metab 2012; 7:445-59; PMID:23144647; http://dx.doi.org/10.1586/ eem.12.33
6. Yen SS. The placenta as the third brain. J Reprod Med 1994; 39:277-80; PMID:8040844
7. Tate PH, Bird AP. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 1993; 3:226-31; PMID:8504247; http:// dx.doi.org/10.1016/0959-437X(93)90027-M
8. Novakovic B, Saffery R. The ever growing complexity of placental epigenetics-role in adverse pregnancy outcomes and fetal programming. Placenta 2012; 33:959-70; PMID:23102655; http://dx.doi.org/10.1016/j. placenta.2012.10.003
9. Deneris ES, Wyler SC. Serotonergic transcriptional networks and potential importance to mental health. Nat Neurosci 2012; 15:519-27; PMID:22366757; http://dx.doi.org/10.1038/nn.3039
10. Velasquez JC, Goeden N, Bonnin A. Placental serotonin: implications for the developmental effects of SSRIs and maternal depression. Front Cell Neurosci 2013; 7:47; PMID:23630464; http://dx.doi. org/10.3389/fncel.2013.00047
11. Bonnin A, Torii M, Wang L, Rakic P, Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci 2007; 10:588-97; PMID:17450135; http://dx.doi.org/10.1038/nn1896
12. Buznikov GA, Lambert HW, Lauder JM. Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Res 2001; 305:177-86; PMID:11545255; http://dx.doi. org/10.1007/s004410100408
13. Bonnin A, Levitt P. Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain. Neuroscience 2011; 197:1-7; PMID:22001683; http://dx.doi. org/10.1016/j.neuroscience.2011.10.005
14. Sonier B, Lavigne C, Arseneault M, Ouellette R, Vaillancourt C. Expression of the 5-HT2A serotoninergic receptor in human placenta and choriocarcinoma cells: mitogenic implications of serotonin. Placenta 2005; 26:484-90; PMID:15950062; http://dx.doi. org/10.1016/j.placenta.2004.08.003
15. Oufkir T, Vaillancourt C. Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. Placenta 2011; 32:1033-40; PMID:21993263; http://dx.doi. org/10.1016/j.placenta.2011.09.005
16. Sato K. Placenta-derived hypo-serotonin situations in the developing forebrain cause autism. Med Hypotheses 2013; 80:368-72; PMID:23375670; http://dx.doi. org/10.1016/j.mehy.2013.01.002
17. Broekman BF, Chan YH, Goh L, Fung D, Gluckman PD, Saw SM, et al. Influence of birth weight on internalizing traits modulated by serotonergic genes. Pediatrics 2011; 128:e1250-8; PMID:21969281; http://dx.doi.org/10.1542/peds.2010-3714
18. Falkenberg VR, Gurbaxani BM, Unger ER, Rajeevan MS. Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association. Neuromolecular Med 2011; 13:66-76; PMID:20941551; http://dx.doi. org/10.1007/s12017-010-8138-2
19. Abdolmaleky HM, Yaqubi S, Papageorgis P, Lambert AW, Ozturk S, Sivaraman V, et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res 2011; 129:183-90; PMID:21550210; http://dx.doi. org/10.1016/j.schres.2011.04.007
20. Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol 2005; 106:1071-83; PMID:16260528; http:// dx.doi.org/10.1097/01.AOG.0000183597.31630.db
21. Law KL, Stroud LR, LaGasse LL, Niaura R, Liu J, Lester BM. Smoking during pregnancy and newborn neurobehavior. Pediatrics 2003; 111:1318-23; PMID:12777547; http://dx.doi.org/10.1542/ peds.111.6.1318
22. Bromer C, Marsit CJ, Armstrong DA, Padbury JF, Lester B. Genetic and epigenetic variation of the glucocorticoid receptor (NR3C1) in placenta and infant neurobehavior. Dev Psychobiol 2012; PMID:22714792; http://dx.doi.org/10.1002/dev.21061
23. Marsit CJ, Maccani MA, Padbury JF, Lester BM. Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome. PLoS One 2012; 7:e33794; PMID:22432047; http://dx.doi. org/10.1371/journal.pone.0033794
24. Lambertini L, Marsit CJ, Sharma P, Maccani M, Ma Y, Hu J, et al. Imprinted gene expression in fetal growth and development. Placenta 2012; 33:480-6; PMID:22465419; http://dx.doi.org/10.1016/j.placenta. 2012.03.001
25. Jensen Peña C, Monk C, Champagne FA. Epigenetic effects of prenatal stress on 11β-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain. PLoS One 2012; 7:e39791; PMID:22761903; http://dx.doi. org/10.1371/journal.pone.0039791
26. Liu J, Bann C, Lester B, Tronick E, Das A, Lagasse L, et al. Neonatal neurobehavior predicts medical and behavioral outcome. Pediatrics 2010; 125:e90-8; PMID:19969621; http://dx.doi.org/10.1542/ peds.2009-0204
27. Talge NM, Neal C, Glover V. Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health. Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 2007; 48:245-61; PMID:17355398; http://dx.doi.org/10.1111/j.1469-7610.2006.01714.x
28. Gluckman PD, Cutfield W, Hofman P, Hanson MA. The fetal, neonatal, and infant environments-the long-term consequences for disease risk. Early Hum Dev 2005; 81:51-9; PMID:15707715; http://dx.doi. org/10.1016/j.earlhumdev.2004.10.003
29. Sandman CA, Davis EP. Neurobehavioral risk is associated with gestational exposure to stress hormones. Expert Rev Endocrinol Metab 2012; 7:445-59; PMID:23144647; http://dx.doi.org/10.1586/ eem.12.33
30. Sandman CA, Davis EP, Glynn LM. Prescient human fetuses thrive. Psychol Sci 2012; 23:93-100; PMID:22173740; http://dx.doi. org/10.1177/0956797611422073
31. Fink NS, Tronick E, Olson K, Lester B. Healthy newborns' neurobehavior: norms and relations to medical and demographic factors. J Pediatr 2012; 161:1073-9, e3; PMID:22727876; http://dx.doi.org/10.1016/j. jpeds.2012.05.036
32. El-Dib M, Massaro AN, Glass P, Aly H. Neurobehavioral assessment as a predictor of neurodevelopmental outcome in preterm infants. J Perinatol 2012; 32:299-303; PMID:21760584; http://dx.doi. org/10.1038/jp.2011.100
33. Lester BM, Tronick EZ. History and description of the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Pediatrics 2004; 113:634-40; PMID:14993523
34. Stephens BE, Liu J, Lester B, Lagasse L, Shankaran S, Bada H, et al. Neurobehavioral assessment predicts motor outcome in preterm infants. J Pediatr 2010; 156:366-71; PMID:19880137; http://dx.doi. org/10.1016/j.jpeds.2009.09.042