GPR88 Reveals a Discrete Function of Primary Cilia as Selective Insulators of GPCR Cross-Talk

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Marley, Aaron ^a   Choy, Regina Wai Yan ^a   von Zastrow, Mark ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; DOPAMINE 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; PROTEIN GPR88; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EUKARYOTIC FLAGELLUM; MOLECULAR INTERACTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BIOSENSING TECHNIQUES; CELL MEMBRANE; CELLS, CULTURED; CILIA; CYCLIC AMP; EMBRYO, MAMMALIAN; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR CROSS-TALK; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, DOPAMINE D1; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING;

EID: 84880970481     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070857     Document Type: Article

References (35)

1. Nachury MV, Seeley ES, Jin H, (2010) Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Annu Rev Cell Dev Biol 26: 59-87.
2. Handel M, Schulz S, Stanarius A, Schreff M, Erdtmann-Vourliotis M, et al. (1999) Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience 89: 909-926.
3. Marley A, von Zastrow M, (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS One 5: e10902.
4. Hamon M, Doucet E, Lefevre K, Miquel MC, Lanfumey L, et al. (1999) Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Neuropsychopharmacology 21: 68S-76S.
5. Brailov I, Bancila M, Brisorgueil MJ, Miquel MC, Hamon M, et al. (2000) Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res 872: 271-275.
6. Berbari NF, Johnson AD, Lewis JS, Askwith CC, Mykytyn K, (2008) Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors. Mol Biol Cell 19: 1540-1547.
7. Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, et al. (2013) The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell 152: 210-223.
8. Choi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, et al. (2011) Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A 108: 10679-10684.
9. Green JA, Gu C, Mykytyn K, (2012) Heteromerization of ciliary G protein-coupled receptors in the mouse brain. PLoS One 7: e46304.
10. Massart R, Guilloux JP, Mignon V, Sokoloff P, Diaz J, (2009) Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents. Eur J Neurosci 30: 397-414.
11. Quintana A, Sanz E, Wang W, Storey GP, Guler AD, et al. (2012) Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nat Neurosci 15: 1547-1555.
12. Yoder BK, Richards WG, Sweeney WE, Wilkinson JE, Avener ED, et al. (1995) Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease. Proc Assoc Am Physicians 107: 314-323.
13. Lohse MJ, Nuber S, Hoffmann C, (2012) Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacol Rev 64: 299-336.
14. Gao X, Zhang J, (2010) FRET-based activity biosensors to probe compartmentalized signaling. Chembiochem 11: 147-151.
15. Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, et al. (2008) beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem 283: 2949-2961.
16. Schafer J, Baumeister H, Meyerhof W, Nehring R, Richter D, (1996) Characterization of cloned somatostatin receptor subtypes. Localization of rat SSTRs in gastrointestinal tissues, SSTR1 gene promoter studies, and mutational analyses of SSTR3. Ann N Y Acad Sci 805: 601-606.
17. Nagai T, Yamada S, Tominaga T, Ichikawa M, Miyawaki A, (2004) Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A 101: 10554-10559.
18. Allen MD, DiPilato LM, Rahdar M, Ren YR, Chong C, et al. (2006) Reading dynamic kinase activity in living cells for high-throughput screening. ACS Chem Biol 1: 371-376.
19. Chen C, Nakamura T, Koutalos Y, (1999) Cyclic AMP diffusion coefficient in frog olfactory cilia. Biophys J 76: 2861-2867.
20. Mizushima K, Miyamoto Y, Tsukahara F, Hirai M, Sakaki Y, et al. (2000) A novel G-protein-coupled receptor gene expressed in striatum. Genomics 69: 314-321.
21. Ghate A, Befort K, Becker JA, Filliol D, Bole-Feysot C, et al. (2007) Identification of novel striatal genes by expression profiling in adult mouse brain. Neuroscience 146: 1182-1192.
22. Logue SF, Grauer SM, Paulsen J, Graf R, Taylor N, et al. (2009) The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders? Mol Cell Neurosci 42: 438-447.
23. Thirstrup K (2010) Constitutively active mutants of GPR88 and uses thereof. Patentscope. Denmark: H. Lundbeck A/S.
24. Goldstein DS, Eisenhofer G, Kopin IJ, (2006) Clinical catecholamine neurochemistry: a legacy of Julius Axelrod. Cell Mol Neurobiol 26: 695-702.
25. Sunahara RK, Dessauer CW, Gilman AG, (1996) Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol 36: 461-480.
26. Prezeau L, Rives ML, Comps-Agrar L, Maurel D, Kniazeff J, et al. (2010) Functional crosstalk between GPCRs: with or without oligomerization. Curr Opin Pharmacol 10: 6-13.
27. Marley A, von Zastrow M, (2012) A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia. PLoS One 7: e46647.
28. Vickery RG, von Zastrow M, (1999) Distinct dynamin-dependent and-independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J Cell Biol 144: 31-43.
29. von Zastrow M, Kobilka BK, (1992) Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J Biol Chem 267: 3530-3538.
30. Guan XM, Kobilka TS, Kobilka BK, (1992) Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide. J Biol Chem 267: 21995-21998.
31. Cao TT, Mays RW, von Zastrow M, (1998) Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pits. J Biol Chem 273: 24592-24602.
32. Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D, (2002) Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295: 868-872.
33. Xu W, Schluter OM, Steiner P, Czervionke BL, Sabatini B, et al. (2008) Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron 57: 248-262.
34. Yu YJ, Arttamangkul S, Evans CJ, Williams JT, von Zastrow M, (2009) Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons. J Neurosci 29: 222-233.
35. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M, (2011) Endocytosis promotes rapid dopaminergic signaling. Neuron 71: 278-290.