Synthesis of indazole substituted-1,3,4-thiadiazoles and their anticonvulsant activity

Drug Invention Today

Volumn 5, Issue 2, 2013, Pages 92-99

  Harish, Kikkeri P ^a   Mohana, Kikkeri N ^a   Mallesha, Lingappa ^b  

^a UNIVERSITY OF MYSORE   (India)

^b JSS College of Arts   (India)

Author keywords

1,3,4 Thiadiazoles; Anticonvulsant activity; Indazole; Neurotoxicity

Indexed keywords

1 METHYL N (5 (4 ((2 NITRO 4 (TRIFLUOROMETHYL)PHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1H INDAZOLE 3 CARBOXAMIDE; 1 METHYL N (5 (4 ((3 (TRIFLUOROMETHYL)PHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1H INDAZOLE 3 CARBOXAMIDE; 1 METHYL N (5 (4 ((4 (TRIFLUOROMETHYL)PHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1H INDAZOLE 3 CARBOXAMIDE; 1 METHYL N (5 (4 TOSYLPIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1H INDAZOLE 3 CARBOXAMIDE; 1 METHYL N (NAPHTHALEN 2 YLSULFONYL) N (5 (4 (NAPHTHALEN 2 YLSULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1H INDAZOLE 3 CARBOXAMIDE; ANTICONVULSIVE AGENT; N (5 (4 ((2,5 DICHLOROTHIOPHEN 3 YL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1 METHYL 1H INDAZOLE 3 CARBOXAMIDE; N (5 (4 ((3,5 BIS(TRIFLUOROMETHYL)PHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1 METHYL 1H INDAZOLE 3 CARBOXAMIDE; N (5 (4 ((3,5 DIMETHYLISOXAZOL 4 YL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1 METHYL 1H INDAZOLE 3 CARBOXAMIDE; N (5 (4 ((4 BROMOPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1 METHYL 1H INDAZOLE 3 CARBOXAMIDE; N (5 (4 ((4 CYANOPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1 METHYL 1H INDAZOLE 3 CARBOXAMIDE; N (5 (4 ((4 IODOPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL)METHYL 1H INDAZOLE 3 CARBOXAMIDE; N (5 (4 (METHYLSULFONYL)PIPERAZIN 1 YL) 1,3,4 THIADIAZOL 2 YL) 1 METHYL 1H INDAZOLE 3 CARBOXAMIDE; PHENYTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG POTENCY; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; MALE; MAXIMAL ELECTROSHOCK SEIZURE MODEL; NEUROTOXICITY; NONHUMAN; RAT; ROTAROD TEST; SEIZURE; STRUCTURE ACTIVITY RELATION;

EID: 84880938787     PISSN: 09757619     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dit.2013.06.002     Document Type: Article

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