Role of intestinal mucosal integrity in HIV transmission to infants through breast-feeding: The BAN study

Journal of Infectious Diseases

Volumn 208, Issue 4, 2013, Pages 653-661

  Kourtis, Athena P ^a   Ibegbu, Chris C ^b   Wiener, Jeffrey ^a   King, Caroline C ^a   Tegha, Gerald ^d   Kamwendo, Deborah ^d   Kumwenda, Jacob ^d   Kaur, Surinder P ^b   Flax, Valerie ^c   Ellington, Sascha ^a   Kacheche, Zebrone ^d   Kayira, Dumbani ^d   Chasela, Charles ^d   Van Der Horst, Charles ^c   Jamieson, Denise J ^a  

^a NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

Author keywords

Breast feeding; HIV; Immune activation; Infant; Intestinal permeability; Microbial translocation

Indexed keywords

COTRIMOXAZOLE; LIPOPOLYSACCHARIDE;

ANTIBIOTIC PROPHYLAXIS; ARTICLE; BREAST FEEDING; CHILD GROWTH; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSTIMULATION; INFANT; INFANT NUTRITION; INFECTION PREVENTION; INFECTION RATE; INTESTINE MUCOSA; LIMULUS LYSATE TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS TRANSMISSION; WEANING;

BREAST-FEEDING; HIV; IMMUNE ACTIVATION; INFANT; INTESTINAL PERMEABILITY; MICROBIAL TRANSLOCATION;

BACTERIAL TRANSLOCATION; BREAST FEEDING; FEMALE; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; INTESTINAL MUCOSA; LIMULUS TEST; LIPOPOLYSACCHARIDES; MALE; PREGNANCY;

EID: 84880934106     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit221     Document Type: Article

References (33)

1. Kourtis AP, Butera S, Ibegbu C, et al. Breast milk and HIV-1: vector of transmission or vehicle of protection? Lancet Infect Dis 2003; 3: 786-93.
2. Sherman MP. New concepts of microbial translocation in the neonatal intestine: Mechanisms and Prevention. Clin Perinatol 2010; 37:565-79.
3. Catassi C, Bonucci A, Coppa G, et al. Intestinal permeability changes during the first month: effect of natural versus artificial feeding. J Pediatr Gastroenterol Nutr 1995; 21:383-6.
4. Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM. Influence of infant feeding patterns on early mother to child transmission of HIV-1 in Durban, South Africa: a prospective cohort study. South African Vitamin A Study Group. Lancet 1999; 354:471-6.
5. Lunn PG. The impact of infection and nutrition on gut function and growth in childhood. Proceed Nutr Society 2000; 59:147-54.
6. Schietroma M, Carlei F, Cappelli S, Amicucci G. Intestinal permeability and systemic endotoxemia after laparatomic or laparoscopic Cholecystectomy. Ann Surg 2006; 243:359-63.
7. Suffredini AF, Hochstein HD, McMahon FG. Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O: 113 endotoxin. J Infect Dis 1999; 179: 1278-82.
8. Favre D, Ledere S, Kanwar B, et al. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. Plos Pathog 2009; e1000295.
9. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-71.
10. Caradonna L, Amati L, Magrone T, et al. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res 2000; 6:205-14.
11. Cooke KR, Olkiewicz K, Erickson N, Ferrara JL. The role of endotoxin and innate immune response in the pathophysiology of acute graft versus host disease. J Endotoxin Res 2002; 8:441-8.
12. Papasavvas E, Azzoni L, Foulkes A, et al. Increased microbial translocation in less than 180 days old perinatally HIV-positive infants as compared with HIV-exposed uninfected infants of similar age. Pediatr Infect Dis J 2011; 30:877-82.
13. Van der Horst C, Chasela C, Ahmed Y, et al. Modifications of a large HIV prevention clinical trial to fit changing realities: a case study of the Breastfeeding, Antiretroviral, and Nutrition (BAN) protocol in Lilongwe, Malawi. Contemp Clin Trials 2009; 30:24-33.
14. Jamieson DJ, Chasela CS, Hudgens MG, et al. Maternal and infant antiretroviral regimens to prevent postnatal HIV-1 transmission: 48 week follow-up of the BAN randomized controlled trial. Lancet 2012; 379: 2449-58.
15. WHO Multicentre Growth Reference Study Group. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. Geneva:World Health Organization, 2006.
16. Bryson YJ, Luzuriaga K, Sullivan JL, et al. Proposed definitions for in utero versus intrapartum transmission of HIV-1. N Engl J Med 1992; 327:1246-7.
17. Kourtis AP, Ibegbu CC, Theiler R, et al. Breast milk CD4+ T cells express high levels of C chemokine receptor 5 and CXC chemokine receptor 4 and are preserved in HIV-infected mothers receiving highly active antiretroviral therapy. J Infect Dis. 2007; 195:965-72.
18. Wallet MA, Rodriguez CA, Lin Y, et al. Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T cell activation following therapy. AIDS 2010; 24:1281-90.
19. Planchon SM, Martins CA, Guerrant RL, et al. Regulation of intestinal epithelial barrier function. J Immunol 1994; 153:5370-9.
20. Cassol E, Malfeld S, Mahasha P, et al. Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy. J Infect Dis 2010; 202:723-33.
21. Anselmi A, Vendrame D, Rampon O, Giaquinto C, Zanchetta M, De Rossi A. Immune reconstitution in HIV type 1-infected children with different virological responses to antiretroviral therapy. Clin Exp Immunol 2007; 150:442-50.
22. Pilakka-Kanthikeel S, Huang S, Fenton T, Borkowsky W, Cunningham CKPahwa S. Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy. Pediatr Infect Dis J 2012; 31:583-91.
23. Brenchley JM, Paiardini M, Knox KS, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 2008; 112:2826-35.
24. Quing G, Howlett S, Bortolussi R. Lipopolysaccharide binding proteins on polymorphonuclear leucocytes: comparison of adult and neonatal cells. Infect Immun 1996; 64:4638-42.
25. Wold A, Adlerberth I. Breastfeeding and the intestinal microflora of the infant-implications for protection against infectious diseases. Adv Exp Med Biol 2000; 478:77-93.
26. Rollins NC, Filteau SM, Coutsoudis A, Tomkin AM. Feeding mode, intestinal permeability, and neopterin excretion: a longitudinal study in infants of HIV-infected South African women. J Acquir Immune Defic Syndr 2001; 28:132-9.
27. Nielsen S, Nielsen DS, Lauritzen L, Jakobsen M, Michaelson K. Impact of diet on the intestinal microbiota in 10-month-old infants. J Pediatr Gastroenterol Nutr 2007; 44:613-8.
28. Kourtis AP, Wiener J, Kayira D, et al. Health outcomes of HIV-exposed uninfected African infants. AIDS 2013; 27:749-59.
29. Taha TE, Hoover DR, Chen S, et al. Effects of cessation of breastfeeding in HIV-1-exposed, uninfected children in Malawi. Clin Infect Dis 2011; 53:388-95.
30. Mulenga V, Ford D, Walker AS, et al. Effect of cotrimoxazole on causes of death, hospital admissions and antibiotic use in HIV-infected children. AIDS 2007; 21:77-84.
31. Cunningham-Rundles S, Ahrne S, Johann-Liang R, et al. Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients 2011; 3:1042-70.
32. Campbell DI, Elia M, Lunn PG. Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr 2003; 133: 1332-8.
33. Lunn PG, Northrop-Clewes CA, Downes RM. Intestinal permeability, mucosal injurty, and growth faltering in Gambian infants. Lancet 1991; 338:907-10.