Hollow hydroxyapatite microspheres: A novel bioactive and osteoconductive carrier for controlled release of bone morphogenetic protein-2 in bone regeneration

Acta Biomaterialia

Volumn 9, Issue 9, 2013, Pages 8374-8383

  Xiao, Wei ^a   Fu, Hailuo ^a   Rahaman, Mohamed N ^a   Liu, Yonxing ^a   Bal, B Sonny ^b  

^a Architectural and Environmental Engineering   (United States)

^b University of Missouri   (United States)

Author keywords

Bone morphogenetic protein 2; Bone regeneration; Hollow hydroxyapatite microspheres; Rat calvarial defect model

Indexed keywords

BIODEGRADABLE POLYMERS; HYDROXYAPATITE; MICROSPHERES; PLASTIC COATINGS; PORE SIZE; PROTEINS; RATS; THICKNESS MEASUREMENT;

BIOACTIVES; BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; CALVARIAL DEFECTS; DEFECT MODEL; HOLLOW HYDROXYAPATITE MICROSPHERE; HYDROXYAPATITE MICROSPHERES; MORPHOGENETICS; OSTEOCONDUCTIVE; RAT CALVARIAL DEFECT MODEL;

BONE;

BONE MORPHOGENETIC PROTEIN 2; HYDROXYAPATITE; MICROSPHERE; POLYGLACTIN;

ARTICLE; BONE CONDUCTION; BONE DEFECT; BONE GROWTH; BONE REGENERATION; IMPLANTATION; IN VITRO STUDY; INFRARED SPECTROSCOPY; OSSIFICATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

BOVINAE; RATTUS;

EID: 84880920595     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.05.029     Document Type: Article

References (43)

1. P.V. Giannoudis, H. Dinopoulos, and E. Tsiridis Bone substitutes: an update Injury 36S 2005 S20 S37
2. W.R. Moore, S.E. Graves, and G.I. Bain Synthetic bone graft substitutes ANZ J Surg 71 2001 354 361
3. C. Laurencin, Y. Khan, and S.F. El-Amin Bone graft substitutes Expert Rev Med Devices 3 2006 49 57
4. J.C. Fernyhough, J.J. Schimandle, and M.C. Weigel Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion Spine 17 1992 1474 1480 (Pubitemid 23001601)
5. C.R. Perry Bone repair techniques, bone graft and bone graft substitutes Clin Orthop Relat Res 360 1999 71 86 (Pubitemid 29140936)
6. J.E. Fleming, C.N. Cornell, and G.E. Muschler Bone cells and matrices in orthopedic tissue engineering Orthop Clin North Am 31 2000 357 374 (Pubitemid 30624511)
7. V. Devescovi, E. Leonardi, G. Ciapetti, and E. Cenni Growth factors in bone repair Chir Organi Mov 92 2008 161 168
8. C.A. Kirker-Head Potential applications and delivery strategies for bone morphogenetic proteins Adv Drug Deliv Rev 43 2000 65 92
9. J.E. Babensee, L.V. McIntire, and A.G. Mikos Growth factor delivery for tissue engineering Pharm Res 17 2000 497 504 (Pubitemid 30416385)
10. Day DE, Conzone SA. Method for preparing porous shells or gels from glass particles. US Patent No. 6,358,531, March 19, 2002.
11. S.D. Conzone, and D.E. Day Preparation and properties of porous microspheres made form borate glass J Biomed Mater Res A 88 2009 531 542
12. H. Fu, M.N. Rahaman, D.E. Day, and Q. Fu Effect of process variables on the microstructure of hollow hydroxyapatite microspheres prepared by a glass conversion method J Am Ceram Soc 93 2010 3116 3123
13. H. Fu, M.N. Rahaman, D.E. Day, and R.F. Brown Hollow hydroxyapatite microspheres as a device for controlled delivery of proteins J Mater Sci Mater Med 22 2011 579 591
14. H. Fu, M.N. Rahaman, R.F. Brown, and D.E. Day Evaluation of BSA protein release from hollow HA microspheres into PEG hydrogel Mater Sci Eng C 33 2013 2245 2250
15. H. Fu, M.N. Rahaman, R.F. Brown, and D.E. Day Evaluation of bone regeneration in implants composed of hollow HA microspheres loaded with transforming growth factor 1 in a rat calvarial defect model Acta Biomater 9 2013 5718 5719
16. J.R. Liberman, A. Daluiski, and T.A. Einhorn The role of growth factors in the repair of bone J Bone Joint Surg Am 84 2002 1032 1044
17. P. Ruhé, H. Kroese-Deutman, J. Wolke, P. Spauwen, and J. Jansen Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants in cranial defects in rabbits Biomaterials 25 2004 2123 2132 (Pubitemid 38102412)
18. J. Wang, M.J. Glimcher, J. Mah, H.Y. Zhou, and E. Salih Expression of bone microsomal casein kinase ii, bone sialoprotein, and osteopontin during the repair of calvarial defects Bone 22 1998 621 628 (Pubitemid 28284610)
19. D.E. Day, J.E. White, R.F. Brown, and K.D. McMenamin Transformation of borate glasses into biologically useful materials Glass Technol 44 2003 75 81
20. E.P. Barrett, L.G. Joyney, and P.P. Halenda The determination of pore volume and area distributions in porous substances I: computations from nitrogen isotherms J Am Chem Soc 73 1951 373 380
21. S.K. Nandi, B. Kundu, and D. Basu Protein growth factors loaded highly porous chitosan scaffold: a comparison of bone healing properties Mater Sci Eng C 33 2013 1267 1275
22. F.C.J. Van de Watering, J.D.M. Molkenboer-Kuenen, O.C. Boerman, J.J.J.P. van den Beucken, and J.A. Jansen Differential loading methods for BMP-2 within injectable calcium phosphate cement J Control Release 164 2012 283 290
23. J.Q. Feng, J. Zhang, S.L. Dallas, Y. Lu, S. Chen, and X. Tan Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene J Bone Miner Res 17 2002 1822 1831
24. L.F. Bonewald, S.E. Harris, J. Rosser, M.R. Dallas, S.L. Dallas, and N.P. Camacho Von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation Calcif Tissue Int 72 2003 537 547 (Pubitemid 36958554)
25. M. Vignoles, G. Bonel, D.W. Holcomb, and R.A. Young Influence of preparation conditions on the composition of type B carbonated hydroxyapatite and on the localization of the carbonate ions Calcif Tissue Int 43 1988 33 40
26. E.J. Carragee, E.L. Hurwitz, and B.K. Weiner A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned Spine J 11 2011 471 491
27. E.J. Woo Does bone morphogenetic protein increase the incidence of perioperative complications in spinal fusion? A comparison of 55,862 cases of spinal fusion with and without bone morphogenetic protein Spine 37 2012 259
28. T. Boix, J. Gomez-Morales, J. Torrent-Burgues, A. Monfort, P. Puigdomenech, and R. Rodriguez-Clemente Adsorption of recombinant human bone morphogenetic protein rhBMP-2 onto hydroxyapatite J Inorg Biochem 99 2005 1043 1050
29. P.Q. Ruhe, O.C. Boerman, F.G. Russel, A.G. Mikos, P.H. Spauwen, and J.A. Jansen In vivo release of rhBMP-2 loaded porous calcium phosphate cement pretreated with albumin J Mater Sci Mater Med 17 2006 919 927 (Pubitemid 44411286)
30. H. Autefage, F. Briand-Mesange, S. Cazalbou, C. Drouet, D. Fourmy, and S. Goncalves Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/beta-tricalcium phosphate porous ceramics J Biomed Mater Res B Appl Biomater 91 2009 706 715
31. Y. Donnyi, H. Iwanaga, T. Shibutani, Y. Moriwaki, and Y. Iwayama Osteoclastic responses to various calcium phosphates in cell cultures J Biomed Mater Res 47 1999 424 433
32. S. Leeuwenburgh, P. Layrolle, F. Barrère, J. de Bruijn, J. Schoonman, and C.A. van Blitterswijk Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro J Biomed Mater Res 56 2001 208 215 (Pubitemid 32520695)
33. R.Z. LeGeros Biodegradation/bioresorption of CaP materials Clin Mater 14 1993 65 88
34. S.V. Dorozhkin Calcium orthophosphates. Occurrence properties biomineralization, pathological, calcification, and biomimetic applications Biomatter 1 2011 121 164
35. R. Rohanizadeh, and K. Chung Hydroxyapatite as a carrier for bone morphogenetic protein J Oral Implantol 37 2011 659 672
36. B. Perri, M. Cooper, C. Lauryssen, and N. Anand Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study Spine J 7 2007 235 239
37. S.D. Boden Bioactive factors for bone tissue engineering Clin Orthop Relat Res 367 1999 S84 S94
38. M. Murnaghan, L. McIlmurray, M.T. Mushipe, and G. Li Time for treating bone fracture using rhBMP-2: a randomised placebo controlled mouse fracture trial J Orthop Res 23 2005 625 631 (Pubitemid 40631335)
39. M. Suzawa, Y. Takeuchi, S. Fukumoto, S. Kato, N. Ueno, and K. Miyazono Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro Endocrinology 140 1999 2125 2133 (Pubitemid 30636451)
40. L. Bi, S.B. Jung, D.E. Day, K. Neidig, V. Dusevich, and J.D. Eick Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical-sized rat calvarial defects implanted with bioactive glass scaffolds J Biomed Mater Res A 100 2012 3267 3275
41. L. Bi, M.N. Rahaman, D.E. Day, Z. Brown, C. Samujh, and X. Liu Effect of borate bioactive glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model Acta Biomater 9 2013 8015 8026
42. J. Zhao, G. Shen, C. Liu, S. Wang, W. Zhang, X. Zhang, D. Zhang Ye, J. Wei, Z. Zhang, and X. Jiang Enhanced healing of rat calvarial defects with sulfated chitosan-coated calcium-deficient hydroxyapatite/bone morphogenetic protein 2 scaffolds Tissue Eng A 18 2012 185 197
43. J.-W. Jang, J.H. Yun, K.-I. Lee, J.-W. Jang, U.-W. Jung, and C.-S. Kim Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats Oral Surg Oral Med O 113 2011 480 487