Development and validation of an assay to detect porcine reproductive and respiratory syndrome virus-specific neutralizing antibody titers in pig oral fluid samples

Clinical and Vaccine Immunology

Volumn 20, Issue 8, 2013, Pages 1305-1313

  Ouyang, Kang ^a,b   Binjawadagi, Basavaraj ^b   Kittawornrat, Apisit ^c   Olsen, Chris ^c   Hiremath, Jagadish ^b   Elkalifa, Nadia ^b   Schleappi, Rose ^b   Wu, Jianmin ^a   Zimmerman, Jeffrey ^c   Renukaradhya, Gourapura J ^b  

^a GUANGXI UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTERIVIRUS MODIFIED LIVE VACCINE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS RNA; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTERIVIRUS; ARTICLE; BLOOD SAMPLING; BOAR (MALE PIG); CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HERD IMMUNITY; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; MALE; NONHUMAN; PIG FARMING; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; SALIVA ANALYSIS; SENSITIVITY AND SPECIFICITY; SOW (SWINE); STANDARDIZATION; VALIDATION PROCESS; VIRUS STRAIN; VIRUS VIRULENCE; WEANING;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; MOUTH; NEUTRALIZATION TESTS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; REPRODUCIBILITY OF RESULTS; SALIVA; SENSITIVITY AND SPECIFICITY; SWINE; TIME FACTORS; VETERINARY MEDICINE;

EID: 84880912729     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00276-13     Document Type: Article

References (37)

1. Albina E. 1997. Epidemiology of porcine reproductive and respiratory syndrome (PRRS): an overview. Vet. Microbiol. 55:309-316.
2. Benfield DA, Nelson E, Collins JE, Harris L, Goyal SM, Robison D, Christianson WT, Morrison RB, Gorcyca D, Chladek D. 1992. Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332). J. Vet. Diagn. Invest. 4:127-133.
3. Marie JC, Kehren J, Trescol-Biémont MC, Evlashev A, Valentin H, Walzer T, Tedone R, Loveland B, Nicolas JF, Rabourdin-Combe C, Horvat B. 2001. Mechanism of measles virus-induced suppression of inflammatory immune responses. Immunity 14:69-79.
4. Lopez OJ, Osorio FA. 2004. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 102:155-163.
5. Labarque GG, Nauwynck HJ, Van Reeth K, Pensaert MB. 2000. Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J. Gen. Virol. 81:1327-1334.
6. Osorio FA, Galeota JA, Nelson E, Brodersen B, Doster A, Wills R, Zuckermann F, Laegreid WW. 2002. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology 302:9-20.
7. Lopez OJ, Oliveira MF, Garcia EA, Kwon BJ, Doster A, Osorio FA. 2007. Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSV-neutralizing antibodies is dose dependent. Clin. Vaccine Immunol. 14:269-275.
8. Ramirez A, Wang C, Prickett JR, Pogranichniy R, Yoon KJ, Main R, Johnson JK, Rademacher C, Hoogland M, Hoffmann P, Kurtz A, Kurtz E, Zimmerman J. 2012. Efficient surveillance of pig populations using oral fluids. Prev. Vet. Med. 104:292-300.
9. McKie A, Vyse A, Maple C. 2002. Novel methods for the detection of microbial antibodies in oral fluid. Lancet Infect. Dis. 2:18-24.
10. Tamura T, Chiba S, Chiba Y, Nakao T. 1980. Virus excretion and neutralizing antibody response in saliva in human cytomegalovirus infection. Infect. Immun. 29:842-845.
11. Parry JV, Perry KR, Mortimer PP. 1987. Sensitive assays for viral antibodies in saliva: an alternative to tests on serum. Lancet 2:72-75.
12. Cuzzubbo AJ, Vaughn DW, Nisalak A, Suntayakorn S, Aaskov J, Devine PL. 1998. Detection of specific antibodies in saliva during dengue infection. J. Clin. Microbiol. 36:3737-3739.
13. Piacentini SC, Thieme TR, Beller M, Davidson SL. 1993. Diagnosis of hepatitis A, B, and C using oral samples. Ann. N. Y. Acad. Sci. 694:334- 336.
14. Nokes DJ, Enquselassie F, Nigatu W, Vyse AJ, Cohen BJ, Brown DW, Cutts FT. 2001. Has oral fluid the potential to replace serum for the evaluation of population immunity levels? A study of measles, rubella and hepatitis B in rural Ethiopia. Bull. World Health Organ. 79:588-595.
15. Douglas RG, Jr Rossen RD, Butler WT, Couch RB. 1967. Rhinovirus neutralizing antibody in tears, parotid saliva, nasal secretions and serum. J. Immunol. 99:297-303.
16. Brandtzaeg P. 2007. Do salivary antibodies reliably reflect both mucosal and systemic immunity? Ann. N. Y. Acad. Sci. 1098:288-311.
17. Gerber PF, O'Neill K, Owolodun O, Wang C, Harmon K, Zhang J, Halbur PG, Zhou L, Meng XJ, Opriessnig T. 2013. Comparison of commercial real-time reverse transcription-PCR assays for reliable, early, and rapid detection of heterologous strains of porcine reproductive and respiratory syndrome virus in experimentally infected or noninfected boars by use of different sample types. J. Clin. Microbiol. 51:547-556.
18. Vanhee M, Delputte PL, Delrue I, Geldhof MF, Nauwynck HJ. 2009. Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies. Vet. Res. 40:63. doi:10.1051/vetres/2009046.
19. Prickett J, Simer R, Christopher-Hennings J, Yoon KJ, Evans RB, Zimmerman JJ. 2008. Detection of porcine reproductive and respiratory syndrome virus infection in porcine oral fluid samples: a longitudinal study under experimental conditions. J. Vet. Diagn. Invest. 20:156-163.
20. Prickett JR, Johnson J, Murtaugh MP, Puvanendiran S, Wang C, Zimmerman JJ, Opriessnig T. 2011. Prolonged detection of PCV2 and anti-PCV2 antibody in oral fluids following experimental inoculation. Transbound. Emerg. Dis. 58:121-127.
21. Kittawornrat A, Wang C, Anderson G, Ballagi A, Broes A, Carman S, Doolittle K, Galeota J, Johnson J, Lizano S, Nelson E, Patnayak D, Pogranichniy R, Rice A, Scherba G, Zimmerman J. 2012. Ring test evaluation of the repeatability and reproducibility of a porcine reproductive and respiratory syndrome virus oral fluid antibody enzyme-linked immunosorbent assay. J. Vet. Diagn. Invest. 24:1057-1063.
22. Wang Z, Bao J, Wu X, Liu Y, Li L, Liu C, Suo L, Xie Z, Zhao W, Zhang W, Yang N, Li J, Wang S, Wang J. 2009. Peste des petits ruminants virus in Tibet, China. Emerg. Infect. Dis. 15:299-301.
23. Langenhorst RJ, Lawson S, Kittawornrat A, Zimmerman JJ, Sun Z, Li Y, Christopher-Hennings J, Nelson EA, Fang Y. 2012. Development of a fluorescent microsphere immunoassay for detection of antibodies against porcine reproductive and respiratory syndrome virus using oral fluid samples as an alternative to serum-based assays. Clin. Vaccine Immunol. 19: 180-189.
24. Ata FA, al Sumry HS, King GJ, Ismaili SI, Ata AA. 1989. Duration of maternal immunity to peste des petits ruminants. Vet. Rec. 124:590-591.
25. Waldman RH, Mann JJ, Kasel JA. 1968. Influenza virus neutralizing antibody in human respiratory secretions. J. Immunol. 100:80-85.
26. Chiba Y, Nakao T. 1972. Mumps virus neutralizing antibody in saliva following natural infection. Tohoku J. Exp. Med. 106:75-81.
27. Schlender J, Schnorr JJ, Spielhoffer P, Cathomen T, Cattaneo R, Billeter MA, ter Meulen V, Schneider-Schaulies S. 1996. Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro. Proc. Natl. Acad. Sci. U. S. A. 93:13194-13199.
28. Yamanouchi K, Fukuda A, Kobune F, Yoshikawa Y, Chino F. 1974. Pathogenesis of rinderpest virus infection in rabbits. II. Effect of rinderpest virus on the immune functions of rabbits. Infect. Immun. 9:206-211.
29. Kim WI, Lee DS, Johnson W, Roof M, Cha SH, Yoon KJ. 2007. Effect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infection. Vet. Microbiol. 123:1-14.
30. Kim WI, Kim JJ, Cha SH, Yoon KJ. 2008. Different biological characteristics of wild-type porcine reproductive and respiratory syndrome viruses and vaccine viruses and identification of the corresponding genetic determinants. J. Clin. Microbiol. 46:1758-1768.
31. Christopher-Hennings J, Holler LD, Benfield DA, Nelson EA. 2001. Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars. J. Vet. Diagn. Invest. 13:133-142.
32. Loeffen W, Quak S, de Boer-Luijtze E, Hulst M, van der Poel W, Bouwstra R, Maas R. 2012. Development of a virus neutralisation test to detect antibodies against Schmallenberg virus and serological results in suspect and infected herds. Acta Vet. Scand. 54:44. doi:10.1186/1751-0147 -54-44.
33. Lee-Huang S, Huang PL, Sun Y, Kung HF, Blithe DL, Chen HC. 1999. Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin. Proc. Natl. Acad. Sci. U. S. A. 96:2678-2681.
34. Shugars DC. 1999. Endogenous mucosal antiviral factors of the oral cavity. J. Infect. Dis. 179(Suppl 3):S431-S435. doi:10.1086/314799.
35. Baron S, Singh I, Chopra A, Coppenhaver D, Pan J. 2000. Innate antiviral defenses in body fluids and tissues. Antiviral Res. 48:71-89.
36. Meier WA, Galeota J, Osorio FA, Husmann RJ, Schnitzlein WM, Zuckermann FA. 2003. Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Virology 309:18-31.
37. Yoon IJ, Joo HS, Goyal SM, Molitor TW. 1994. A modified serum neutralization test for the detection of antibody to porcine reproductive and respiratory syndrome virus in swine sera. J. Vet. Diagn. Invest. 6:289- 292.