Effect of sugammadex on QT/QTc interval prolongation when combined with QTc-prolonging sevoflurane or propofol anaesthesia

Clinical Drug Investigation

Volumn 33, Issue 8, 2013, Pages 545-551

  De Kam, Pieter Jan ^a   Grobara, Peter ^b   Dennie, Justin ^a   Cammu, Guy ^c   Ramael, Steven ^d   Jagt Smook, Marjan L F ^b   Van Den Heuvel, Michiel W ^b   Berg, Rob J W ^b   Peeters, Pierre A M ^b,e  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MSD   (Netherlands)

^c OLV HOSPITAL   (Belgium)

^d SGS Life Science Services   (Belgium)

^e CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPYRRONIUM BROMIDE; NEOSTIGMINE; PLACEBO; PROPOFOL; SEVOFLURANE; SUGAMMADEX;

ADULT; ARTICLE; BACKACHE; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG INDUCED HEADACHE; DYSGEUSIA; ELECTROCARDIOGRAM; FEMALE; HUMAN; HYPERBILIRUBINEMIA; HYPOTENSION; MALE; NAUSEA; OROPHARYNX PAIN; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SIDE EFFECT; SINGLE BLIND PROCEDURE; SOMNOLENCE;

ADULT; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ELECTROCARDIOGRAPHY; GAMMA-CYCLODEXTRINS; HEART; HUMANS; METHYL ETHERS; MIDDLE AGED; PLACEBOS; PROPOFOL;

EID: 84880912551     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.1007/s40261-013-0095-8     Document Type: Article

References (21)

1. Adam JM, Bennett DJ, Bom A, et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. J Med Chem. 2002;45:1806-16.
2. Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl. 2002;41:266-70.
3. Bom A, Epemolu O, Hope F, et al. Selective relaxant binding agents for reversal of neuromuscular blockade. Curr Opin Pharmacol. 2007;7:298-302.
4. Jones RK, Caldwell JE, Brull SJ, Soto RG. Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine. Anesthesiology. 2008;109:816-24.
5. Blobner M, Eriksson LI, Scholz J, et al. Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. Eur J Anaesthesiol. 2010;27:874-81.
6. Khuenl-Brady KS, Wattwil M, Vanacker BF, et al. Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial. Anesth Analg. 2010;110:64-73.
7. Lemmens HJ, El-Orbany MI, Berry J, et al. Reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia: sugammadex versus neostigmine. BMC Anesthesiol. 2010;10:15.
8. Saarnivaara L, Klemola UM, Lindgren L, et al. QT interval of the ECG, heart rate and arterial pressure using propofol, methohexital or midazolam for induction of anaesthesia. Acta Anaesthesiol Scand. 1990;34:276-81.
9. Kleinsasser A, Kuenszberg E, Loeckinger A, et al. Sevoflurane, but not propofol, significantly prolongs the Q-T interval. Anesth Analg. 2000;90:25-7.
10. Chang DJ, Kweon TD, Nam SB, et al. Effects of fentanyl pretreatment on the QTc interval during propofol induction. Anaesthesia. 2008;63:1056-60.
11. Paventi S, Santevecchi A, Ranieri R. Effects of sevoflurane versus propofol on QT interval. Minerva Anestesiol. 2001;67:637-40.
12. Yildirim H, Adanir T, Atay A, et al. The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG. Eur J Anaesthesiol. 2004;21:566-70.
13. de Kam PJ, van Kuijk J, Prohn M, et al. Effects of sugammadex doses up to 32 mg/kg alone or in combination with rocuronium or vecuronium on QTc prolongation: a thorough QTc study. Clin Drug Investig. 2010;30:599-611.
14. de Kam PJ, van Kuijk J, Smeets J, et al. Sugammadex is not associated with QT/QTc prolongation: methodology aspects of an intravenous moxifloxacin-controlled thorough QT study. Int J Clin Pharmacol Ther. 2012;50:595-604.
15. Schneider TW, Minto CF, Gambus PL, et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998;88:1170-82.
16. Guidance for industry: E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. 2005. http://www.fda.gov/downloads/RegulatoryInformation/Guidances/ucm129357.pdf. Accessed January 2013.
17. Saarnivaara L, Simola M. Effects of four anticholinesterase- anticholinergic combinations and tracheal extubation on QTc interval of the ECG, heart rate and arterial pressure. Acta Anaesthesiol Scand. 1998;42:460-3.
18. Van den Broek L, Proost JH, Wierda JM, et al. Neuromuscular and cardiovascular effects of neostigmine and methyl-atropine administered at different degrees of rocuronium-induced neuromuscular block. Eur J Anaesthesiol. 1994;11:481-7.
19. van Vlymen JM, Parlow JL. The effects of reversal of neuromuscular blockade on autonomic control in the perioperative period. Anesth Analg. 1997;84:148-54.
20. Chiladakis J, Kalogeropoulos A, Arvanitis P, et al. Preferred QT correction formula for the assessment of drug-induced QT interval prolongation. J Cardiovasc Electrophysiol. 2010;21:905-13.
21. Lock G, Fialho GL, Castro DL, Almeida MCS. Electrocardiographic changes after neostigmine-atropine mixture. J Anesth Clinic Res. 2012;3:2.