Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: Results of a randomised, controlled trial

European Journal of Anaesthesiology

Volumn 27, Issue 10, 2010, Pages 874-881

  Blobner, Manfred ^a   Eriksson, Lars I ^b   Scholz, Jens ^c   Motsch, Johann ^d   Della Rocca, Giorgio ^e   Prins, Martine E ^f  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e UNIVERSITY HOSPITAL OF UDINE   (Italy)

^f MSD   (Netherlands)

Author keywords

Anaesthetics; Gamma cyclodextrins; Inhalation; Neostigmine; Neuromuscular blockade; Rocuronium; Sevoflurane; Sugammadex

Indexed keywords

NEOSTIGMINE; PROPOFOL; ROCURONIUM; SEVOFLURANE; SUGAMMADEX;

ABDOMINAL PAIN; ACCELEROMYOGRAPHY; ADULT; ANESTHESIA INDUCTION; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ELECTIVE SURGERY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MYOGRAPHY; NEUROMUSCULAR BLOCKING; PHASE 3 CLINICAL TRIAL; PREDICTION; RANDOMIZED CONTROLLED TRIAL; VITAL SIGN;

ADULT; AGED; ANDROSTANOLS; ANESTHETICS, INHALATION; CHOLINESTERASE INHIBITORS; FEMALE; GAMMA-CYCLODEXTRINS; HUMANS; MALE; METHYL ETHERS; MIDDLE AGED; NEOSTIGMINE; NEUROMUSCULAR BLOCKADE; NEUROMUSCULAR NONDEPOLARIZING AGENTS; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD;

EID: 77956816834     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e32833d56b7     Document Type: Article

References (29)

1. Kopman A, Kopman D, Ng J, Zank L. Antagonism of profound cisatracurium and rocuronium block: the role of objective assessment of neuromuscular function. J Clin Anesth 2005; 17:30-35.
2. Bevan JC, Collins L, Fowler C, et al. Early and late reversal of rocuronium and vecuronium with neostigmine in adults and children. Anesth Analg 1999; 89:333-339.
3. Tramer MR, Fuchs-Buder T. Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic review. Br J Anaesth 1999; 82:379-386.
4. Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl 2002; 41:266-270.
5. Sorgenfrei IF, Norrild K, Larsen PB, et al. Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study. Anesthesiology 2006; 104:667-674.
6. Sparr HJ, Vermeyen KM, Beaufort AM, et al. Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: efficacy, safety, and pharmacokinetics. Anesthesiology 2007; 106:935-943.
7. 7Puhringer FK, Rex C, Sielenkamper AW, et al. Reversal of profound, highdose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose- finding, safety assessor-blinded, phase II trial. Anesthesiology 2008; 109:188-197.
8. Jones RK, Caldwell JE, Brull SJ, Soto RG. Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine. Anesthesiology 2008; 109:816-824.
9. Shields M, Giovannelli M, Mirakhur RK, et al. Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced block. Br J Anaesth 2006; 96:36-43.
10. Blobner M, Eriksson L, Scholz J, et al. Sugammadex (2.0mg/kg) significantly faster reverses shallow rocuronium-induced neuromuscular blockade compared with neostigmine (50 μg/kg) [abstract #9AP7-10]. Eur J Anaesthesiol 2007; 24 (Suppl 39):125.
11. Khuenl-Brady KS, Wattwil M, Vanacker BF, et al. Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial. Anesth Analg 2010; 110:64-73.
12. Viby-Mogensen J, Engbaek J, Eriksson L, et al. Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents. Acta Anaesthesiol Scand 1996; 40:59-74.
13. Fuchs-Buder T, Claudius C, Skovgaard LT, et al. Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision. Acta Anaesthesiol Scand 2007; 51:789-808.
14. Suy K, Morias K, Cammu G, et al. Effective reversal of moderate rocuronium-or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent. Anesthesiology 2007; 106:283-288.
15. Reid JE, Breslin DS, Mirakhur RK, Hayes AH. Neostigmine antagonism of rocuronium block during anesthesia with sevoflurane, isoflurane or propofol. Can J Anaesth 2001; 48:351-355.
16. Abdulatif M, Mowafi H, al-Ghamdi A, el-Sanabary M. Dose-response relationships for neostigmine antagonism of rocuronium-induced neuromuscular block in children and adults. Br J Anaesth 1996; 77:710-715.
17. McCourtKC, Mirakhur RK, Kerr CM. Dosage of neostigmine for reversal of rocuronium block from two levels of spontaneous recovery. Anaesthesia 1999; 54:651-655.
18. Bartkowski RR. Incomplete reversal of pancuronium neuromuscular blockade by neostigmine, pyridostigmine, and edrophonium. Anesth Analg 1987; 66:594-598.
19. Vanacker BF, Vermeyen KM, Struys MM, et al. Reversal of rocuronium- induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane. Anesth Analg 2007; 104:563-568.
20. Rex C, Wagner S, Spies C, et al. Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia. Anesthesiology 2009; 111:30-35.
21. Kim K, Cheong M, Lee H, Lee J. Tactile assessment for the reversibility of rocuronium-induced neuromuscular blockade during propofol or sevoflurane anesthesia. Anesth Analg 2004; 99:1080-1085.
22. Flockton EA, Mastronardi P, Hunter JM, et al. Reversal of rocuronium- induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine. Br J Anaesth 2008; 100:622-630.
23. Lee C, Jahr JS, Candiotti KA, et al. Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine. Anesthesiology 2009; 110:1020-1025.
24. Naguib M, Abdulatif M, al-Ghamdi A. Dose-response relationships for edrophonium and neostigmine antagonism of rocuronium bromide (ORG 9426)-induced neuromuscular blockade. Anesthesiology 1993; 79:739-745. (Pubitemid 23296705)
25. Kopman AF, Chin W, Cyriac J. Acceleromyography vs. electromyography: an ipsilateral comparison of the indirectly evoked neuromuscular response to train-of-four stimulation. Acta Anaesthesiol Scand 2005; 49:316-322.
26. Capron F, Alla F, Hottier C, et al. Can acceleromyography detect low levels of residual paralysis? A probability approach to detect a mechanomyographic train-of-four ratio of 0.9. Anesthesiology2004; 100:1119-1124.
27. Salem MG, Richardson JC, Meadows GA, et al. Comparison between glycopyrrolate and atropine in a mixture with neostigmine for reversal of neuromuscular blockade. Studies in patients following open heart surgery. Br J Anaesth 1985; 57:184-187.
28. Mirakhur RK, Jones CJ, Dundee JW. Effects of intravenous administration of glycopyrrolate and atropine in anaesthetised patients. Anaesthesia 1981; 36:277-281.
29. Heier T, Clough D, Wright PM, et al. The influence of mild hypothermia on the pharmacokinetics and time course of action of neostigmine in anesthetized volunteers. Anesthesiology 2002; 97:90-95.