Polymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases

BMC Endocrine Disorders

Volumn 13, Issue , 2013, Pages

  Zhang, Jian ^a   Xiao, Wan Xiao ^b   Zhu, Yuan Feng ^c,d   Muhali, Fatuma Said ^c   Xiao, Ling ^c   Jiang, Wen Juan ^c   Shi, Xiao Hong ^c   Zhou, Lian Hua ^c   Zhang, Jin An ^c  

^a JINSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^b Internal Medicine Department   (China)

^c FUDAN UNIVERSITY   (China)

^d Central Hospital of Weinan City   (China)

Author keywords

Graves' disease; Hashimoto's thyroiditis; Interleukin 21 (IL 21); Interleukin 21 receptor (IL 21R); Single nucleotide polymorphism (SNP)

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR;

ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GRAVES DISEASE; HAPLOTYPE; HASHIMOTO DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; POLYMERASE CHAIN REACTION; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84880885052     PISSN: None     EISSN: 14726823     Source Type: Journal    
DOI: 10.1186/1472-6823-13-26     Document Type: Article

References (19)

1. Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA 2000, 97:1439-1444.
2. Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000, 408:57-63. 10.1038/35040504, 11081504.
3. Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ, Morse HC, Leonard WJ, Roopenian DC. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 2009, 106:1518-1523. 10.1073/pnas.0807309106, 2635818, 19164519.
4. Li J, Shen W, Kong K, Liu Z. Interleukin -21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 2006, 64:515-522. 10.1111/j.1365-3083.2006.01795.x, 17032244.
5. Yuan SL, Jiang L, Zhang XL, Li SF, Duan HM, Wang XF. Serum IL-21 level in patients with primary Sjogren's syndrome and clinical significance of IL-21. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007, 23:124-126.
6. Jia HY, Zhang ZG, Gu XJ, Guo T, Cui B, Ning G, Zhao YJ. Association between interleukin 21 and Graves' disease. Genet Mol Res 2011, 10:3338-3346. 10.4238/2011.October.31.6, 22057994.
7. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678. 10.1038/nature05911, 2719288, 17554300, Wellcome Trust Case Control Consortium.
8. Zhernakova A, Alizadeh BZ, Bevova M, Van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, Van Heel DA, Van der Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet 2007, 81:1284-1288. 10.1086/522037, 2276343, 17999365.
9. Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, Packham J, Worthington J, Thomson W. Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Genes Immun 2010, 11:194-198. 10.1038/gene.2009.105, 2845517, 20072139.
10. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008, 4:e1000041. 10.1371/journal.pgen.1000041, 2274885, 18369459.
11. Adamovic S, Amundsen SS, Lie BA, Gudjónsdóttir AH, Ascher H, Ek J, Van Heel DA, Nilsson S, Sollid LM, Torinsson Naluai A. Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families. Genes Immun 2008, 9:364-367. 10.1038/gene.2008.27, 18418394.
12. Garner CP, Murray JA, Ding YC, Tien Z, Van Heel DA, Neuhausen SL. Replication of celiac disease UK genome-wide association study results in a US population. Hum Mol Genet 2009, 18:4219-4225. 10.1093/hmg/ddp364, 2758145, 19648293.
13. Festen EA, Goyette P, Scott R, Annese V, Zhernakova A, Lian J, Lefèbvre C, Brant SR, Cho JH, Silverberg MS, Taylor KD, De Jong DJ, Stokkers PC, Mcgovern D, Palmieri O, Achkar JP, Xavier RJ, Daly MJ, Duerr RH, Wijmenga C, Weersma RK, Rioux JD. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 2009, 5:799-804.
14. Fedetz M, Ndagire D, Fernandez O, Leyva L, Guerrero M, Arnal C, Lucas M, Izquierdo G, Delgado C, Alcina A, Matesanz F. Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population. Tissue Antigens 2009, 74:244-247. 10.1111/j.1399-0039.2009.01298.x, 19523143.
15. Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DR, James JA, Merrill JT, Lipsky P, Harley JB. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis 2008, 67:458-461.
16. Webb R, Merrill JT, Kelly JA, Sestak A, Kaufman KM, Langefeld CD, Ziegler J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Alarcón-Riquelme ME, James JA, Gilkeson GS, Jacob CO, Moser KL, Gaffney PM, Vyse TJ, Nath SK, Lipsky P, Harley JB, Sawalha AH. A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum 2009, 60:2402-2407. 10.1002/art.24658, 2782592, 19644854.
17. Plagnol V, Howson JM, Smyth DJ, Walker N, Hafler JP, Wallace C, Stevens H, Jackson L, Simmonds MJ, Bingley PJ, Gough SC, Todd JA,. Type 1 Diabetes Genetics Consortium Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet 2011, 7:e1002216. 10.1371/journal.pgen.1002216, 3150451, 21829393, Type 1 Diabetes Genetics Consortium.
18. De Nitto D, Sarra M, Pallone F, Monteleone G. Interleukin-21 triggers effector cell responses in the gut. World J Gastroenterol 2010, 16:3638-3641. 10.3748/wjg.v16.i29.3638, 2915423, 20677335.
19. Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005, 5:688-698. 10.1038/nri1688, 16138102.