The distribution of cagA and dupA genes in Helicobacter pylori strains in Kurdistan region, northern Iraq

Annals of Saudi Medicine

Volumn 33, Issue 3, 2013, Pages 290-293

  Salih, Azad M ^a   Goreal, Amer ^a   Hussein, Nawfal R ^a   Abdullah, Shahla M ^b   Hawrami, Khidir ^b   Assafi, Mahde ^c  

^a UNIVERSITY OF DUHOK   (Iraq)

^b KOYA UNIVERSITY   (Iraq)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CAGA GENE; DISEASE ASSOCIATION; DUODENUM ULCER; DUPA GENE; GASTROINTESTINAL ENDOSCOPY; GENETIC ASSOCIATION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IRAQ; MAJOR CLINICAL STUDY; NONHUMAN; PEPTIC ULCER; POLYMERASE CHAIN REACTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH ULCER;

ADULT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CROSS-SECTIONAL STUDIES; DUODENAL ULCER; ENDOSCOPY, GASTROINTESTINAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IRAQ; MIDDLE AGED; PEPTIC ULCER; POLYMERASE CHAIN REACTION; PREVALENCE; STOMACH ULCER; VIRULENCE FACTORS; YOUNG ADULT;

EID: 84880879419     PISSN: 02564947     EISSN: 09754466     Source Type: Journal    
DOI: 10.5144/0256-4947.2013.290     Document Type: Article

References (21)

1. Atherton J. The Pathogenesis of H pylori-Induced Gastro-Duodenal Diseases. Annual Review of: Mechanisms of Disease 2006;1:63-96.
2. Bandipalliam P. MALT lymphomas-a closer look in the genomics era. South Med J 2006;99(12):1322-4.
3. Forman D, Newell DG, Fullerton F, Yarnell JW, Stacey AR, Wald N, Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Bmj 1991;302(6788):1302-5.
4. Akopyants NS, Clifton SW, Kersulyte D, Crabtree JE, Youree BE, Reece CA, Bukanov NO, Drazek ES, Roe BA, Berg DE. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol 1998;28(1):37-53.
5. Atherton JC. H pylori virulence factors. Br Med Bull 1998;54(1):105-120.
6. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55(10):2111-5.
7. Lu H, Hsu PI, Graham DY, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology 2005;128(4):833-848.
8. Arachchi HS, Kalra V, Lal B, Bhatia V, Baba CS, Chakravarthy S, Rohatgi S, Sarma PM, Mishra V, Das B, Ahuja V. Prevalence of duodenal ulcerpromoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter 2007;12(6):591-7.
9. Argent RH, Burette A, Miendje Deyi VY, Atherton JC. The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis 2007;45(9):1204-6.
10. Rudi J, Kolb C, Maiwald M, Kuck D, Sieg A, Galle PR, Stremmel W. Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases. J Clin Microbiol 1998;36(4):944-948.
11. Hussein NR, Argent RH, Marx CK, Patel SR, Robinson K, Atherton JC. Helicobacter pylori dupA Is Polymorphic, and Its Active Form Induces Proinflammatory Cytokine Secretion by Mononuclear Cells. Journal of Infectious Diseases 2010;202(2):261-269.
12. Khalifa M, Sharaf R, Aziz R. Helicobacter pylori: a poor man's gut pathogen? Gut Pathogens 2010;2(1):2.
13. Brown LM. Helicobacter Pylori: Epidemiology and Routes of Transmission. Epidemiologic Reviews 2000;22(2):283-297.
14. Hussein NR, Mohammadi M, Talebkhan Y, Doraghi M, Letley DP, Muhammad MK, Argent RH, Atherton JC. Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H pylori-associated disease. J Clin Microbiol 2008;46(5):1774-9.
15. Momenah AM, Tayeb MT. Helicobacter pylori cagA and iceA genotypes status and riskof peptic ulcer in Saudi patients. Saudi Med J 2007;28 (3):382-385.
16. Saribasak H SB, Yamaoka Y, Sander E. Analysis of Helicobacter pylori genotypes and correlation with clinical outcome in Turkey. J Clin Microbiol 2004;42:1648-1651.
17. Dabiri H, Maleknejad P, Yamaoka Y, Feizabadi MM, Jafari F, Rezadehbashi M, Nakhjavani FA, Mirsalehian A, Zali MR. Distribution of Helicobacter pylori cagA, cagE, oipA and vacA in different major ethnic groups in Tehran, Iran. Journal of Gastroenterology and Hepatology 2009;24(8):1380-1386.
18. Salehi Z, Jelodar M, Rassa M, Ahaki M, Mollasalehi H, Mashayekhi F. Helicobacter pylori cagA Status and Peptic Ulcer Disease in Iran. Digestive Diseases and Sciences 2009;54(3):608-613.
19. Talebkhan Y, Mohammadi M, Mohagheghi M, Vaziri H, Eshagh Hosseini M, Mohajerani N, Oghalaei A, Esmaeili M, Zamaninia L. cagA Gene and Protein Status Among Iranian Helicobacter pylori Strains. Digestive Diseases and Sciences 2008;53(4):925-932.
20. Gomes LI, Rocha GA, Rocha AM, Soares TF, Oliveira CA, Bittencourt PF, Queiroz DM. Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol 2007;298:223-230.
21. Hussein NR, Napaki S, Atherton J. A study of Helicobacter pylori -associated gastritis patterns in Iraq and their association with strain virulence. Saudi J Gastroenterol. 2009;15(2):125-127.