Synthetic strategy toward γ-KETO NITRILES and their Biocatalytic conversion to asymmetric γ-lactones

Synthesis (Germany)

Volumn 45, Issue 15, 2013, Pages 2171-2178

  Franz, Sarah E ^a   Watkins, Richard R ^a   Wright, Laura A ^a   Weaver, Blair A ^a   Hartage, Ramon C ^a   Ghiviriga, Ion ^b   Gumina, Giuseppe ^c   Feske, Brent D ^a  

^a Armstrong State University   (United States)

^b University of Florida ^*  (United States)

^c GEORGIA SOUTHERN UNIVERSITY   (United States)

Author keywords

asymmetric catalysis; asymmetric synthesis; enzymes; lactones; reduction

Indexed keywords

ASYMMETRIC CATALYSIS; ASYMMETRIC SYNTHESIS; ENZYMATIC REACTION; INTRAMOLECULAR CYCLIZATIONS; KETOREDUCTASES; LACTONES; SCALED-UP; SYNTHETIC STRATEGIES;

CYANIDES; CYCLIZATION; ENZYMES; REDUCTION;

ESTERS;

2 (2 CHLOROETHYL) 2 (4 CHLOROPHENYL) 1,3 DITHIANE; 2 (2 CHLOROETHYL) 2 (4 METHOXYPHENYL) 1,3 DITHIANE; 2 (2 CHLOROETHYL) 2 4 TOLYL 1,3-DITHIANE; 2 (4 CHLOROPHENYL) 1,3 DITHIANE; 2 (4 METHOXYPHENYL) 1,3 DITHIANE; 2 4 TOLYL 1,3 DITHIANE; 2 ALKYL 1,3 DITHIANE 2A; 2 ALKYL 2 (2 CHLOROETHYL) 1,3 DITHIANE; 2 ARYL 1,3DITHIANES; 2 ARYL 2 (2 CHLOROETHYL) 1,3 DITHIANES; 2 BUTYL 1,3 DITHIANE; 2 ETHYL 1,3 DITHIANE; 3 (2 4 TOLYL 1,3 DITHIANE 2 YL)PROPANENITRILE; 3 (2 BUTYL 1,3 DITHIAN 2 YL)PROPANENITRILE; 3 (2 ETHYL 1,3 DITHIAN 2 YL)PROPANENITRILE; 3 (2 HEXYL 1,3 DITHIAN 2 YL)PROPANENITRILE; 3 [2 (4 CHLOROPHENYL) 1,3 DITHIAN 2 YL]PROPANENITRILE; 3 [2 (4 METHOXYPHENYL) 1,3 DITHIAN 2 YL]PROPANENITRILE; 4 (4 CHLOROPHENYL) 4 OXOBUTANENITRILE; 4 (4 METHOXYPHENYL) 4 OXOBUTANENITRILE; 4 HYDROXYHEXANENITRILE; 4 OXO 4 4 TOLYLBUTANENITRILE; 4 OXODECANENITRILE; 4 OXOOCTANENITRILE; GAMMA KETO NITRILE; GAMMA LACTONE DERIVATIVE; LACTONE DERIVATIVE; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC CATALYSIS; ASYMMETRIC SYNTHESIS; BIOCATALYSIS; CARBON NUCLEAR MAGNETIC RESONANCE; ELIMINATION REACTION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROLYSIS; INFRARED SPECTROSCOPY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RHODOCOCCUS; RHODOCOCCUS RHODOCHROUS; SYNTHESIS;

EID: 84880853590     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0033-1339282     Document Type: Article

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