Modulation of multiple sclerosis by sunlight exposure: Role of cis-urocanic acid

Journal of Neuroimmunology

Volumn 261, Issue 1-2, 2013, Pages 134-140

  Correale, Jorge ^a   Farez, Mauricio F ^a  

^a FLENI   (Argentina)

Author keywords

Cytokines; Environmental factors; Multiple sclerosis; Ultraviolet radiation; Urocanic acid

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; SEROTONIN 2A RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UROCANIC ACID;

ADULT; ANTIGEN PRESENTATION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SUN EXPOSURE; T LYMPHOCYTE;

CYTOKINES; ENVIRONMENTAL FACTORS; MULTIPLE SCLEROSIS; ULTRAVIOLET RADIATION; UROCANIC ACID;

ADULT; BIOLOGICAL MARKERS; BRAZIL; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; SUNLIGHT; UROCANIC ACID;

EID: 84880823165     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2013.05.014     Document Type: Article

References (28)

1. Albert E., Waljker J., Thiesen A., Churchill T., Madsen K. cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation. PLoS One 2010, 5:e13676.
2. Alter M., Kahana E., Lowenson R. Migration and risk of multiple sclerosis. Neurology 1978, 28:1089-1093.
3. Bacci S., Nakamura T., Streilein J.W. Failed antigen presentation after UVB radiation correlates with modifications of Langerhans cell cytoskeleton. J. Invest. Dermatol. 1996, 107:838-843.
4. Beissert S., Rühlemann D., Mohammad T., Grabbe S., El-Ghorr A., Norval M., Morrison H., Granstein R.D., Schwarz T. IL-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells: implications for photocarcinogenesis. J. Immunol. 2001, 167:6232-6238.
5. Beklund B.R., Severson K.S., Vang S.V., DeLuca H.F. UV radiation suppress experimental autoimmune encephalomyelitis independent of vitamin D production. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:6418-6423.
6. Correale J., Farez M. Monocyte-derived dendritic cells in multiple sclerosis: the effect of bacterial infections. J. Neuroimmunol. 2007, 190:177-189.
7. Correale J., McMillan M., McCarthy K., Le T., Weiner L.P. Isolation and characterization of autoreactive proteolipid protein-peptide specific T cell clones from multiple sclerosis patients. Neurology 1995, 45:1370-1378.
8. Correale J., Ysrraelit M.C., Gaitán M.I. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain 2009, 132:1146-1160.
9. Gibbs N.K., Tye J., Norval M. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem. Photobiol. Sci. 2008, 7:655-667.
10. Gruner S., Diezel W., Stoppe H., Oesterwitz H., Henke W. Inhibition of skin allograft rejection and acute graft-versus host disease by urocanic acid. J. Invest. Dermatol. 1991, 98:459-462.
11. Halliday G.M., Damian D.L., Rana S., Byrne S.N. The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: implications for autoimmunity. J. Dermatol. Sci. 2012, 66:176-182.
12. Hart P.H., Gorman S., Finlay-Jones J. Modulation of the immune system by UV radiation: more than just the effects of vitamin D?. Nat. Rev. Immunol. 2011, 11:584-596.
13. + T cells. J. Immunol. 1998, 161:3237-3241.
14. Kammeyer A., Pavel S., Asghar S.S., Bos J.D., Teunissen B.M. Prolonged increase of cis-UCA acid levels in human skin and urine after single total-body ultraviolet exposures. Photochem. Photobiol. 1997, 65:593-598.
15. Kurimoto I., Streilein J.W. cis-Urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-alpha. J. Immunol. 1992, 148:3072-3078.
16. Lucas R.M., Ponsonby A.L., Dear K., Valery P., Pender M.P., Burrows J.M., Burrows S.R., Chapman C., Coulthard A., Dwyer D.E., Dwyer T., Kilpatrick T., Lay M.L., McMichael A.J., Taylor B.V., van der Mei I.A., Williams D. Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology 2011, 76:540-548.
17. Noonan F.P., De Fabo E.C. Immunosuppression by UVB radiation: initiation by urocanic acid. Immunol. Today 1992, 13:250-254.
18. Norval M., Simpson T.J., Bardshiri E., Howie S.E.M. Urocanic acid analogues and the suppression of DTH response to herpes simplex virus. Photochem. Photobiol. 1989, 49:633-639.
19. Oksenberg J.R., Baranzini S.E., Sawcer S., Hauser S.L. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 2008, 9:516-526.
20. Orton S.M., Wald L., Confavreaux C., Vukusic S., Krohn J.P., Ramagopalan S.V., Herrera B.M., Sadovnick A.D., Ebers G.C. Association of UV radiation with multiple sclerosis prevalence and sex ratio in France. Neurology 2011, 76:425-431.
21. Pugliatti M., Sotgiu S., Rosati G. The worldwide prevalence of multiple sclerosis. Clin. Neurol. Neurosurg. 2002, 104:182-191.
22. Pugliatti M., Harbo H.F., Holmoy T., Kampman M.T., Myhr K.M., Riise T., Wolfson C. Environmental risk factors in multiple sclerosis. Acta Neurol. Scand. Suppl. 2008, 188:34-40.
23. Ramagopalan S.V., Handel A.E., Giovannoni G., Rutherford Siegel S., Ebers G.C., Chaplin G. Relationship of UV exposure to prevalence of multiple sclerosis in England. Neurology 2011, 76:1410-1414.
24. 2A receptor agonist. Bioorg. Med. Chem. Lett. 2009, 19:5307-5309.
25. Simon K.C., Munger K.L., Ascherio A. Vitamin D and multiple sclerosis: epidemiology, immunology and genetics. Curr. Opin. Neurol. 2012, 25:246-251.
26. Sloka S., Silva C., Pryse-Phillips W., Patten W., Metz L., Yong V.W. A quantitative analysis of suspected environmental causes of MS. Can. J. Neurol. Sci. 2011, 38:98-105.
27. A receptor functions by urocanic acid isomers. Eur. J. Pharmacol. 2000, 400:11-17.
28. 2A receptor. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:17420-17425.