Significant damage of the conduction system during cardioplegic arrest is due to necrosis not apoptosis

European Journal of Cardio-thoracic Surgery

Volumn 25, Issue 5, 2004, Pages 801-806

  Sayk, Friedhelm ^a   Krüger, Stefan ^a   Bechtel, J F Matthias ^a   Feller, Alfred C ^a   Sievers, Hans H ^a   Bartels, Claus ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Apoptosis; Cardioplegia; Conduction system; Necrosis; Oncosis; Purkinje fibers

Indexed keywords

CASPASE 3; EOSIN; HEMATOXYLIN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; CRYSTALLOID; DNA STRAND BREAKAGE; ELECTRON MICROSCOPY; EOSINOPHIL; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE ISCHEMIA; IMMUNOHISTOCHEMISTRY; MUSCLE NECROSIS; NICK END LABELING; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PURKINJE CELL; REPERFUSION INJURY; STAINING;

ANIMALS; APOPTOSIS; HEART ARREST, INDUCED; HEART CONDUCTION SYSTEM; MICROSCOPY, ELECTRON; MYOCARDIAL REPERFUSION INJURY; NECROSIS; PURKINJE FIBERS; SWINE; SWINE, MINIATURE;

EID: 1842634665     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2004.01.027     Document Type: Article

References (20)

1. Buckberg G.D. Update on current techniques of myocardial protection. Ann Thorac Surg. 60:1995;805-814.
2. Gundry S.R., Sequeira A., Coughlin T.R., McLaughlin J.S. Postoperative conduction disturbances: a comparison of blood and crystalloid cardioplegia. Ann Thorac Surg. 63:1997;901-902.
3. Mustonen P., Poyhonen M., Rehnberg S., Kuori J., Jaakkola P., Berg E., Loponen P., Hippeläinen M. Conduction defects after coronary artery bypass grafting - a disappearing problem? Ann Chir Gynaecol. 89:2000;33-39.
4. Magilligan D.J., Vij D., Peper W., Allor D., Frinak S., Tilley B. Failure of standard cardioplegic techniques to protect the conduction system. Ann Thorac Surg. 39:1985;403-408.
5. Schnabel P.A., Richter J., Schmiedl A., Ramsauer B., Bartels U., Gebhard M.M., Mall G., Bretschneider H.J. The ultrastructural effects of global ischemia on Purkinje fibres compared with working myocardium: a qualitative and morphometric investigation of the canine heart. Virchows Arch A Pathol Anat. 418:1991;17-25.
6. Canale E.D., Campbell G.R., Smolich J.J., Campbell J.H. Cardiac muscle. 1986;Springer, Berlin.
7. Buja L.M., Entman M.L. Modes of myocardial cell injury and cell death in ischemic heart disease. Circulation. 98:1998;1355-1357.
8. Valen G. The basic biology of apoptosis and its implications for cardiac function and viability. Ann Thorac Surg. 75:2003;S656-S660.
9. Freude B., Masters T.N., Kostin S., Robiscek F., Schaper J. Cardiomyocyte apoptosis in acute and chronic conditions. Basic Res Cardiol. 93:1998;85-89.
10. Saraste A., Pulkki K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res. 45:2000;528-537.
11. Majno G., Joris I. Apoptosis oncosis, and necrosis - an overview of cell death. Am J Pathol. 146:1995;3-15.
12. Schmitt J.P., Schröder J., Schunkert H., Birnbaum D.E., Aebert H. Role of apoptosis in myocardial stunning after open heart surgery. Ann Thorac Surg. 73:2002;1229-1235.
13. Axford-Gatley R.A., Wilson G.J., Feindel C.M. Comparison of blood-based and asanguineous cardioplegic solutions administered at 4°C. J Thorac Cardiovasc Surg. 100:1990;400-409.
14. Schaper J., Scheld H.H., Schmidt U., Hehrlein F. Ultrastructural study comparing the efficacy of five different methods of intraoperative myocardial protection in the human heart. J Thorac Cardiovasc Surg. 92:1986;47-55.
15. Krajewski S., Krajewska M., Shabaik A., Miyashita T., Wang H.G., Reed J.C. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol. 145:1994;1323-1336.
16. Olivetti G., Abbi R., Quaini F., Kajstura J., Cheng W., Nitahara J.A., Quaini E., Di Loreto C., Beltrami C.A., Krajewski S., Reed J.C., Anversa P. Apoptosis in the failing human heart. N Engl J Med. 336:1997;1131-1141.
17. Cotran R.S., Kumar V., Collins T. Cellular pathology I: cell injury and cell death. Cotran K.C.R. Pathologic basis of disease. 1999;1-29 Saunders, Philadelphia, PA.
18. Sharov V.G., Sabbah H.N., Shimoyama H., Goussev A.V., Lesch M., Goldstein S. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J Pathol. 148:1996;141-149.
19. Ohno M., Takemura G., Ohno A., Misao J., Hayakawa Y., Minatoguchi S., Fujiwara T., Fujiwara H. Apoptotic myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation. Circulation. 98:1998;1422-1430.
20. Cohen N.M., Allan C.A., Hsia P.W., Nixon T.E., Wise R.M., Damiano R.J. Electrophysiologic consequences of hyperkalemic cardioplegia during surgical ischemia. Ann Thorac Surg. 57:1994;1076-1083.